Elevated risk of thrombotic manifestations of SARS-CoV-2 infection in cancer patients

A literature review

Authors

  • Annunziata Stefanile Department Clinical Pathology and Cancer Biobank, IRCCS Regina Elena National Cancer Institute, Istituti Fisioterapici Ospitalieri (IFO), 00144 Rome, Italy https://orcid.org/0000-0001-9730-5836
  • Maria Cellerino Department of Clinical Experimental Oncology, IRCCS Regina Elena National Cancer Institute, IFO, Via Elio Chianesi 53, 00144, Rome, Italy; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Mother-Child Health (DINOGMI), University of Genoa, Genoa, Italy. E-mail: maria.cellerino@unige.it https://orcid.org/0000-0002-4359-9872
  • Tatiana Koudriavtseva Medical Direction, IRCCS Regina Elena National Cancer Institute, Istituti Fisioterapici Ospitalieri (IFO), 00144 Rome, Italy https://orcid.org/0000-0001-9984-1827

DOI:

https://doi.org/10.17179/excli2022-5073

Keywords:

SARS-CoV-2, COVID-19, cancer, coagulation, thrombotic manifestations

Abstract

Coronavirus disease 2019 (COVID-19) results in higher risks of hospitalization or death in older patients and those with multiple comorbidities, including malignancies. Patients with cancer have greater risks of COVID-19 onset and worse prognosis. This excess is mainly explained by thrombotic complications. Indeed, an imbalance in the equilibrium between clot formation and bleeding, increased activation of coagulation, and endothelial dysfunction characterize both COVID-19 patients and those with cancer. With this review, we provide a summary of the pathological mechanisms of coagulation and thrombotic manifestations in these patients and discuss the possible therapeutic implications of these phenomena.

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Published

2022-06-30

How to Cite

Stefanile, A., Cellerino, M., & Koudriavtseva, T. (2022). Elevated risk of thrombotic manifestations of SARS-CoV-2 infection in cancer patients: A literature review. EXCLI Journal, 21, 906–920. https://doi.org/10.17179/excli2022-5073

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Review articles

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