Selenium as an important factor in various disease states

a review


  • Marek Kieliszek Department of Food Biotechnology and Microbiology, Institute of Food Sciences, Warsaw University of Life Sciences, Nowoursynowska 159 C, 02-776 Warsaw, Poland; E-mails: or
  • Iqra Bano Department of Veterinary Physiology & Biochemistry, Shaheed Benazir Bhutto University of Veterinary and Animals Sciences Sakrand (SBBUVAS), 67210, Sindh, Pakistan



selenium, antioxidant, oxidative stress, selenoproteins


Selenium (Se) is an element that has a pro-health effect on humans and animals. However, both the deficiency of this element and its excess may prove harmful to the body depending on the chemical form of the selenium, the duration of supplementation, and the human health condition. Many data indicate insufficient coverage of the demand for selenium in humans and animals due to its low content in soils and food products. A balance in the physiological process of the body can be achieved via the proper percentage of organically active minerals in the feed of animals as well as human beings. Selenium is a trace mineral of great importance to the body, required for the maintenance of a variety of its processes; primarily, selenium maintains immune endocrine, metabolic, and cellular homeostasis. Recently, this element has been emerging as a most promising treatment option for various disorders. Therefore, research based on Se has been increasing in recent times. The present review is designed to provide up-to-date information related to Se and its different forms as well as its effects on health.



How to Cite

Kieliszek, M., & Bano, I. (2022). Selenium as an important factor in various disease states: a review. EXCLI Journal, 21, 948–966.



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