Molecular mechanisms of etoposide

Authors

  • Alessandra Montecucco Istituto di Genetica Molecolare, CNR, via Abbiategrasso 207, Pavia
  • Francesca Zanetta Istituto di Genetica Molecolare, CNR, via Abbiategrasso 207, Pavia; Dipartimento di Biologia e Biotecnologia, Università degli Studi di Pavia, via Ferrata 9, Pavia, Italy
  • Giuseppe Biamonti Istituto di Genetica Molecolare, CNR, via Abbiategrasso 207, Pavia

DOI:

https://doi.org/10.17179/excli2014-561

Abstract

Etoposide derives from podophyllotoxin, a toxin found in the American Mayapple. It was first synthesized in 1966 and approved for cancer therapy in 1983 by the U.S. Food and Drug Administration (Hande, 1998). Starting from 1980s several studies demonstrated that etoposide targets DNA topoisomerase II activities thus leading to the production of DNA breaks and eliciting a response that affects several aspects of cell metabolisms. In this review we will focus on molecular mechanisms that account for the biological effect of etoposide.

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Published

2015-01-19

How to Cite

Montecucco, A., Zanetta, F., & Biamonti, G. (2015). Molecular mechanisms of etoposide. EXCLI Journal, 14, 95–108. https://doi.org/10.17179/excli2014-561

Issue

Vol. 14 (2015)

Section

Review articles

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