The interplay between non-coding RNAs and Wnt/β-catenin signaling pathway in urinary tract cancers

from tumorigenesis to metastasis

Authors

  • Farzad Rahmani Kashmar School of Nursing, Mashhad University of Medical Sciences, Mashhad, Iran; Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Basic Medical Sciences Institute, Mashhad University of Medical Sciences, Mashhad, Iran https://orcid.org/0000-0002-8263-0828
  • Pegah Safavi Department of Medical Radiation, Science and Research Branch, Islamic Azad University, Tehran, Iran https://orcid.org/0000-0002-8489-5301
  • Ayda Fathollahpour Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran https://orcid.org/0000-0003-4379-208X
  • Fatemeh Tanhaye Kalate Sabz Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran https://orcid.org/0000-0002-1848-271X
  • Parastoo Tajzadeh Kashmar School of Nursing, Mashhad University of Medical Sciences, Mashhad, Iran https://orcid.org/0000-0003-4951-0784
  • Mohsen Arefnezhad Kashmar School of Nursing, Mashhad University of Medical Sciences, Mashhad, Iran https://orcid.org/0000-0002-3650-3107
  • Gordon A. Ferns Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex, UK https://orcid.org/0000-0002-0957-8349
  • Seyed Mahdi Hassanian Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Basic Medical Sciences Institute, Mashhad University of Medical Sciences, Mashhad, Iran https://orcid.org/0000-0002-9486-0778
  • Amir Avan Basic Medical Sciences Institute, Mashhad University of Medical Sciences, Mashhad, Iran. E-mail: Avana@mums.ac.ir https://orcid.org/0000-0002-4968-0962

DOI:

https://doi.org/10.17179/excli2022-5348

Keywords:

ncRNA, Wnt/β-catenin, urinary tract cancers

Abstract

Non-coding RNAs (ncRNAs) are emerging as important regulators in various pathological conditions including tumorigenesis, metastasis, and drug resistance in human cancers. Oncogenic or tumor suppressor ncRNAs exert prominent effects on cell proliferation, migration and invasion in cancer cells through modulating various signaling pathways including Wnt/β-catenin. Upregulation of the oncogenic Wnt/β-catenin pathway was reported to be implicated in multiple human cancers including breast, liver, colorectal, and urothelial cancers. Therefore, identifying interactions between ncRNAs and canonical Wnt signaling components may represent novel therapeutic targets for better treatment and management of cancer. In this review, we summarized the recent findings about miRNA/lncRNA-dependent mechanisms that regulate Wnt/β-catenin signaling involved in tumorigenesis and metastasis of urinary tract cancers.

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Published

2022-10-18

How to Cite

Rahmani, F., Safavi, P., Fathollahpour, A., Tanhaye Kalate Sabz, F., Tajzadeh, P., Arefnezhad, M., … Avan, A. (2022). The interplay between non-coding RNAs and Wnt/β-catenin signaling pathway in urinary tract cancers: from tumorigenesis to metastasis. EXCLI Journal, 21, 1273–1284. https://doi.org/10.17179/excli2022-5348

Issue

Vol. 21 (2022)

Section

Review articles

Categories

License

Copyright (c) 2022 Farzad Rahmani, Pegah Safavi, Ayda Fathollahpour, Fatemeh Tanhaye Kalate Sabz, Parastoo Tajzadeh, Mohsen Arefnezhad, Gordon A. Ferns, Seyed Mahdi Hassanian, Amir Avan

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