Anti-inflammatory, antioxidant and antitumor activities of ingredients of Curcuma phaeocaulis Val

Authors

  • Yan Hou College of Food and Bioengineering, South China University of Technology, Guangzhou, 510640, China
  • Chuan-Li Lu College of Food and Bioengineering, South China University of Technology, Guangzhou, 510640, China; The Second Institute of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510120, China
  • Qiao-Hui Zeng College of Food and Bioengineering, South China University of Technology, Guangzhou, 510640, China
  • Jian-Guo Jiang College of Food and Bioengineering, South China University of Technology, Guangzhou, 510640, China

DOI:

https://doi.org/10.17179/excli2015-231

Keywords:

Curcuma phaeocaulis Val., anti-oxidant, anti-tumor, anti-inflammatory

Abstract

Curcuma phaeocaulis Val. is used in Chinese Pharmacopoeia as health food and folk medicine for removing blood stasis, alleviating pain and tumor therapy. This research was aimed to explore and compare three main bioactivities including anti-oxidant, antitumor and anti-inflammatory activities between the ethanol extract of C. Phaeocaulis and its fractions using different in vitro models. Firstly, 70 % ethanol was used to extract C. Phaeocaulis, and then the crude extract was re-extracted, resulting in petroleum ether (EZ-PE), ethyl acetate (EZ-EA), and water fractions (EZ-W), respectively, and then a series of index was detected. Results showed that all the extracts had medium DPPH radical scavenging activity when the concentration was 200 μg/ml and their DPPH radical scavenging activity was in a concentration-dependent manner. The extracts except ethanol extract of C. Phaeocaulis had almost no cytotoxicity to the survival of RAW264.7 cell when the concentration reached 80 μg/ml, and all of them had medium inhibitory effect on nitrite release. Extracts of C. Phaeocaulis had medium intensity antitumor activity, EZ-PE and EZ-EA fractions significantly inhibited the proliferation of four tumor cells (SMMC-7721 cell lines, HepG-2 cell lines, A549 cell lines and Hela cell lines). C. Phaeocaulis had antioxidant and anti-inflammatory activities, which did not carry out centralized phenomenon when re-extracted. EZ-PE and EZ-EA were active antitumor sites of C. Phaeocaulis.

Downloads

Published

2015-06-12

How to Cite

Hou, Y., Lu, C.-L., Zeng, Q.-H., & Jiang, J.-G. (2015). Anti-inflammatory, antioxidant and antitumor activities of ingredients of Curcuma phaeocaulis Val. EXCLI Journal, 14, 706–713. https://doi.org/10.17179/excli2015-231

Issue

Vol. 14 (2015)

Section

Original articles

License

Authors who publish in this journal agree to the following terms:

  • The authors keep the copyright and grant the journal the right of first publication under the terms of the Creative Commons Attribution license, CC BY 4.0. This licencse permits unrestricted use, distribution and reproduction in any medium, provided that the original work is properly cited.
  • The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.
  • Because the advice and information in this journal are believed to be true and accurate at the time of publication, neither the authors, the editors, nor the publisher accept any legal responsibility for any errors or omissions presented in the publication. The publisher makes no guarantee, express or implied, with respect to the material contained herein.
  • The authors can enter into additional contracts for the non-exclusive distribution of the journal's published version by citing the initial publication in this journal (e.g. publishing in an institutional repository or in a book).