Brain insulin signaling and cognition

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Authors

  • Habib Yaribeygi Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran. E-mail: habib.yari@yahoo.com https://orcid.org/0000-0002-1706-6212
  • Mina Maleki Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran https://orcid.org/0000-0003-4723-3058
  • Alexandra E. Butler Research Department, Royal College of Surgeons in Ireland, Bahrain, PO Box 15503, Adliya, Bahrain https://orcid.org/0000-0002-5762-3917
  • Tannaz Jamialahamdi Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran https://orcid.org/0000-0001-9521-3153
  • Amirhossein Sahebkar Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. E-mail: amir_saheb2000@yahoo.com https://orcid.org/0000-0002-8656-1444

DOI:

https://doi.org/10.17179/excli2023-5841

Keywords:

Diabetes mellitus, brain insulin signaling, cognition, senile plaque, mitochondria

Abstract

Poor cognitive ability is a consequence of a wide variety of neurobehavioral disorders and is a growing health problem, especially among the elderly and patients with diabetes. The precise underlying cause of this complication is not well-defined. However, recent studies have highlighted the possible role of insulin hormone signaling in brain tissue. Insulin is a metabolic peptide integral to whole body energy homeostasis; it does, however, have extrametabolic impacts, such as upon neuronal circuits. Therefore, it has been suggested that insulin signaling may modify cognitive ability by yet unknown pathways. In the current review, we discuss the cognitive role of brain insulin signaling and consider the possible links between brain insulin signaling and cognitive ability.

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Published

2023-02-13

How to Cite

Yaribeygi, H., Maleki, M., Butler, A. E., Jamialahamdi, T., & Sahebkar, A. (2023). Brain insulin signaling and cognition: Possible links. EXCLI Journal, 22, 237–249. https://doi.org/10.17179/excli2023-5841

Issue

Vol. 22 (2023)

Section

Review articles

Categories

License

Copyright (c) 2023 Habib Yaribeygi, Mina Maleki, Alexandra E. Butler, Tannaz Jamialahamdi, Amirhossein Sahebkar

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