Amount and composition of total fatty acids in red and yellow bone marrow are altered with changes in bone mineral density

Authors

  • Sabrina Ehnert Siegfried-Weller Institute for Trauma Research, BG Trauma Center, University of Tuebingen, Schnarrenbergstrasse 95, 72070 Tuebingen, Germany. Tel: +49-7071-606 1065. E-mail: sabrina.ehnert@med.uni-tuebingen.de https://orcid.org/0000-0003-4347-1702
  • Anna J. Schreiner Siegfried-Weller Institute for Trauma Research, BG Trauma Center, University of Tuebingen, Tuebingen, Germany; RKH Orthopedic Clinic Markgroeningen, 71706 Markgroeningen, Germany https://orcid.org/0000-0001-8073-8176
  • Claudine Seeliger ZIEL Institute for Food & Health, Research Group Lipid Metabolism, Technical University of Munich, Freising, Germany https://orcid.org/0000-0002-7631-444X
  • Josef Ecker ZIEL Institute for Food & Health, Research Group Lipid Metabolism, Technical University of Munich, Freising, Germany https://orcid.org/0000-0003-4799-0788
  • Fabian Springer Department of Diagnostic and Interventional Radiology, University Hospital and BG Trauma Center, University of Tuebingen, Tuebingen, Germany https://orcid.org/0000-0003-4451-7127
  • Gerhard Liebisch Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany https://orcid.org/0000-0003-4886-0811
  • Philipp Hemmann Siegfried-Weller Institute for Trauma Research, BG Trauma Center, University of Tuebingen, Tuebingen, Germany https://orcid.org/0000-0002-0535-5359
  • Tina Histing Siegfried-Weller Institute for Trauma Research, BG Trauma Center, University of Tuebingen, Tuebingen, Germany https://orcid.org/0000-0002-6955-2001
  • Andreas K. Nussler Siegfried-Weller Institute for Trauma Research, BG Trauma Center, University of Tuebingen, Tuebingen, Germany https://orcid.org/0000-0002-6666-6791

DOI:

https://doi.org/10.17179/excli2023-5843

Keywords:

bone mineral density, fatty acid composition, bone marrow, saturated fatty acids, unsaturated fatty acids, Tartrate-Resistant Acidic Phosphatase (TRAP5b)

Abstract

There is general consent that with decreasing bone mineral density the amount of marrow adipose tissue increases. While image-based techniques, claim an increase in saturated fatty acids responsible for this effect, this study shows an increase in both saturated and unsaturated fatty acids in the bone marrow. Using fatty acid methyl ester gas chromatography-mass spectrometry, characteristic fatty acid patterns for patients with normal BMD (N = 9), osteopenia (N = 12), and osteoporosis (N = 9) have been identified, which differ between plasma, red bone marrow and yellow bone marrow. Selected fatty acids, e.g. FA10:0, FA14:1, or FA16:1 n-7 in the bone marrow or FA18:0, FA18:1 n-9, FA18:1 n-7, FA20:0, FA20:1 n-9, or FA20:3 n-6 in the plasma, correlated with osteoclast activity, suggesting a possible mechanism how these fatty acids may interfere with BMD. Although several fatty acids correlated well with the osteoclast activity and BMD, there was not a single fatty acid contained in our fatty acid profile that can be claimed for controlling BMD, a fact that may be attributed to the genetic heterogeneity of the patients.

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Published

2023-02-13

How to Cite

Ehnert, S., Schreiner, A. J., Seeliger, C., Ecker, J., Springer, F., Liebisch, G., … Nussler, A. K. (2023). Amount and composition of total fatty acids in red and yellow bone marrow are altered with changes in bone mineral density. EXCLI Journal, 22, 207–220. https://doi.org/10.17179/excli2023-5843

Issue

Vol. 22 (2023)

Section

Original articles

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Copyright (c) 2023 Sabrina Ehnert, Anna J. Schreiner, Claudine Seeliger, Josef Ecker, Fabian Springer, Gerhard Liebisch, Philipp Hemmann, Tina Histing, Andreas K. Nussler

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