Bladder cancer course, four genetic high-risk variants, and histopathological findings
Keywords:muscle invasive bladder cancer (MIBC), non-muscle invasive bladder cancer (NMIBC), PSCA gene rs2294008 and rs2978974, FGFR3-TACC3 gene region rs798766, CBX6-APOBEC3A gene region rs1014971
Urinary bladder cancer, a smoking and occupation related disease, was subject of several genome-wide association studies (GWAS). However, studies on the course of the disease based on GWAS findings differentiating between muscle invasive bladder cancer (MIBC) and non-muscle invasive bladder cancer (NMIBC) are rare. Thus we investigated 4 single nucleotide polymorphisms (SNPs) detected in GWAS, related to the genes coding for TACC3 (transforming, acidic coiled-coil containing protein 3), for FGFR3 (fibroblast growth factor receptor 3), for PSCA (prostate stem cell antigen) and the genes coding for CBX6 (chromobox homolog 6) and APOBEC3A (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A). This study is based on 712 bladder cancer patients and 875 controls from 3 different case control studies in Germany. The 4 SNPs of interest (PSCA rs2294008 and rs2978974, FGFR3-TACC3 rs798766, and CBX6-APOBEC3A rs1014971) were determined by real-time polymerase chain reaction. The distribution of the 4 SNPs does not vary significantly between cases and controls in the entire study group and in the 3 local subgroups, including two former highly industrialized areas and a region without such history. Also, no significant differences in the bladder cancer subgroups of MIBC and NMIBC were observed. The 4 investigated SNPs do not noticeably contribute differently to the bladder cancer risk for the bladder cancer subgroups of MIBC and NMIBC.
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Copyright (c) 2023 Thura Kadhum, Silvia Selinski, Meinolf Blaszkewicz, Jörg Reinders, Emanuel Roth, Frank Volkert, Daniel Ovsiannikov, Oliver Moormann, Holger Gerullis, Dimitri Barski, Thomas Otto, Svetlana Höhne, Jan G. Hengstler, Klaus Golka
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