A comparative study of natural immune responses against Plasmodium vivax C-terminal merozoite surface protein-1 (PvMSP-1) and apical membrane antigen-1 (PvAMA-1) in two endemic settings

Authors

  • Hui Xia Department of Parasitology, Bengbu Medical College, Anhui 233030, China; Anhui Key Laboratory of Infection and Immunity at Bengbu Medical College, Anhui 233030, China
  • Qiang Fang Department of Parasitology, Bengbu Medical College, Anhui 233030, China; Anhui Key Laboratory of Infection and Immunity at Bengbu Medical College, Anhui 233030, China
  • Kulachart Jangpatarapongsa Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand
  • Tao Zhiyong Department of Parasitology, Bengbu Medical College, Anhui 233030, China
  • Liwang Cui Department of Entomology, Pennsylvania State University, PA 16802, USA
  • Baiqing Li Department of Immunology, Bengbu Medical College, Anhui 233030, China
  • Rachanee Udomsangpetch Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand

DOI:

https://doi.org/10.17179/excli2015-388

Keywords:

malaria immunity, Plasmodium vivax, Plasmodium falciparum, antibody to malaria

Abstract

The mechanisms of cellular and humoral immune responses against P. vivax parasite remain poorly understood. Several malaria immunological studies have been conducted in endemic regions where both P. falciparum and P. vivax parasites co-exist. In this study, a comparative analysis of immunity to Plasmodium vivax antigens in different geography and incidence of Plasmodium spp. infection was performed. We characterised antibodies against two P. vivax antigens, PvMSP-1 and PvAMA-1, and the cross-reactivity between these antigens using plasma from acute malaria infected patients living in the central region of China and in the western border of Thailand. P. vivax endemicity is found in central China whereas both P. vivax and P. falciparum are endemic in Thailand. There was an increased level of anti-PvMSP-1/anti-PvAMA-1 in both populations. An elevated level of antibodies to total P. vivax proteins and low level of antibodies to total P. falciparum proteins was found in acute P. vivax infected Chinese, suggesting antibody cross-reactivity between the two species. P. vivax infected Thai patients had both anti-P. vivax and anti-P. falciparum antibodies as expected since both species are present in Thailand. More information on humoral and cell mediated immunity during acute P. vivax-infection in the area where only single P. vivax species existed is of great interest in the relation of building up anti-disease severity caused by P. falciparum. This knowledge will support vaccine development in the future.

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Published

2015-08-06

How to Cite

Xia, H., Fang, Q., Jangpatarapongsa, K., Zhiyong, T., Cui, L., Li, B., & Udomsangpetch, R. (2015). A comparative study of natural immune responses against Plasmodium vivax C-terminal merozoite surface protein-1 (PvMSP-1) and apical membrane antigen-1 (PvAMA-1) in two endemic settings. EXCLI Journal, 14, 926–934. https://doi.org/10.17179/excli2015-388

Issue

Vol. 14 (2015)

Section

Original articles

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