Sesamol ameliorates hypotension by modulating cytokines and PPAR-gamma in systemic inflammatory response

Authors

  • Srinivasan Periasamy Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan
  • Pei-Yi Chu Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan
  • Ya-Hui Li Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan
  • Dur-Zong Hsu Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan
  • Ming-Yie Liu Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan

DOI:

https://doi.org/10.17179/excli2015-367

Keywords:

acute renal injury, hypotension, inflammatory cytokines, proliferator-activated receptor-gamma, lipopolysaccharides, sesamol, sepsis

Abstract

Sepsis is one of the major causes of death reported in intensive care units. Acute kidney injury (AKI) and hypotension are important in the pathogenesis and mortality of systemic inflammatory response (SIR). Sesamol delays mortality in sepsis; however, its effects on AKI and hypotension and the role of peroxisome proliferator-activated receptor-ɣ (PPAR-γ) activation have not been established. We investigated the effect of sesamol on SIR in cecal ligation and puncture (CLP)-induced acute kidney injury and lipopolysaccharide (LPS)-induced hypotension in rats. Sesamol was subcutaneously injected 1 h after SIR. Renal function (BUN and CRE) and proinflammatory mediators interleukin (IL)-1β and IL-6 were increased after CLP. Tumor necrosis factor (TNF)-α, IL-1β, IL-10, and nitrite production were significantly increased 6 h after LPS-induced hypotension (mean arterial pressure was significantly decreased). Sesamol significantly inhibited BUN, CRE, IL-1β, IL-6, and nitrite after CLP-induced acute renal injury. In addition, sesamol increased mean arterial pressure and IL-10, inhibited TNF-α and IL-1β, but did not affect nitrite production in LPS-induced hypotension. Sesamol increased PPAR-γ in the leucocytes and peritoneal macrophages in LPS-induced SIR. We conclude that sesamol regulates leucocyte and macrophage PPAR-γ-associated systemic cytokines expression, thereby ameliorates acute kidney injury and hypotension in rats.

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Published

2015-08-13

How to Cite

Periasamy, S., Chu, P.-Y., Li, Y.-H., Hsu, D.-Z., & Liu, M.-Y. (2015). Sesamol ameliorates hypotension by modulating cytokines and PPAR-gamma in systemic inflammatory response. EXCLI Journal, 14, 948–957. https://doi.org/10.17179/excli2015-367

Issue

Vol. 14 (2015)

Section

Original articles

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