Circular RNAs

novel actors of Wnt signaling pathway in lung cancer progression

Authors

  • Mina Alimohammadi Student Research Committee, Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran https://orcid.org/0000-0002-5953-3894
  • Yasaman Gholinezhad Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran https://orcid.org/0000-0003-2515-5669
  • Vahide Mousavi School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran https://orcid.org/0000-0002-4382-1357
  • Samaneh Kahkesh Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran https://orcid.org/0009-0008-7402-2962
  • Malihe Rezaee Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran https://orcid.org/0000-0002-4363-7613
  • Alireza Yaghoobi Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran https://orcid.org/0000-0001-9164-6410
  • Alireza Mafi Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. E-mail: armafi.m@gmail.com https://orcid.org/0000-0002-9485-0326
  • Mahmood Araghi Department of Pathology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. E-mail: araghimah@gmail.com https://orcid.org/0000-0003-2056-5589

DOI:

https://doi.org/10.17179/excli2023-6209

Keywords:

CircRNA, Wnt, lung cancer, signaling cascades, mechanism

Abstract

Circular RNAs (CircRNAs) are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukaryotes. CircRNA dysregulation has been shown to disrupt the interaction of the Wnt/β-catenin pathway, which regulates several biological processes involved in tumorigenesis, thereby contributing to the development and progression of cancer. Interactions of tumor-derived circRNAs with the Wnt/β-catenin signaling pathway provide both clinical diagnostic biomarkers and promising therapeutic targets. In this review, we outlined current evidence on the roles of circRNAs associated with the Wnt/β-catenin pathway in regulating lung cancer formation and development. We believe that our findings will assist in the advancement or establishment of circRNA-based lung cancer therapeutic approaches.

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Published

2023-07-12

How to Cite

Alimohammadi, M., Gholinezhad, Y., Mousavi, V., Kahkesh, S., Rezaee, M., Yaghoobi, A., Mafi, A., & Araghi, M. (2023). Circular RNAs: novel actors of Wnt signaling pathway in lung cancer progression. EXCLI Journal, 22, 645–669. https://doi.org/10.17179/excli2023-6209

Issue

Vol. 22 (2023)

Section

Review articles

Categories

License

Copyright (c) 2023 Mina Alimohammadi, Yasaman Gholinezhad, Vahide Mousavi, Samaneh Kahkesh, Malihe Rezaee, Alireza Yaghoobi, Alireza Mafi, Mahmood Araghi

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