DNA damaging and biochemical effects of potassium tetraborate

Authors

  • Fatih Çaglar Çelikezen Department of Chemistry, Science and Letter Faculty, Bitlis Eren University, Turkey
  • Hasan Turkez Department of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Erzurum, Turkey
  • Basak Togar Department of Biology, Faculty of Science, Atatürk University, Turkey
  • Mehmet Sait Izgi Department of Chemistry, Science and Letter Faculty, Bitlis Eren University, Turkey

Keywords:

boron, potassium tetraborate, genotoxicity, oxidative stress, antioxidant

Abstract

Potassium tetraborate (PTB) is a product resulting from the controlled reaction of potassium hydroxide, water and boric acid (BA). It is used in many areas of industry such as disinfectant, detergent and treatment of contact lenses. PTB is one of the boron compounds which is most commonly used in many areas of industry although very limited information is available concerning its toxicity. Therefore, in this study, it is aimed to determine genetic and biochemical effects of PTB in human blood cell cultures (n=4). PTB was added into culture tubes at various concentrations (0-1280 µg/ml). Micronucleus (MN) and chromosomal aberration (CA) tests were performed for genotoxic damage influences estimation. In addition, biochemical parameters (total antioxidant capacity (TAC) and total oxidative status (TOS) were examined to determine oxidative effects. The results indicated that all tested concentrations of PTB were found to be non-genotoxic. In addition, low concentrations (1.25, 2.5 and 5 µg/ml) of PTB caused increases of TAC levels. Furthermore, all concentrations of PTB were not changed the TOS levels in cultured human blood cells. Based on these results, in this study it has been reported for the first time that PTB is not genotoxic and it increases the antioxidant capacity in human peripheral blood lymphocytes.

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Published

2014-04-30

How to Cite

Çelikezen, F. Çaglar, Turkez, H., Togar, B., & Izgi, M. S. (2014). DNA damaging and biochemical effects of potassium tetraborate. EXCLI Journal, 13, 446–450. Retrieved from https://www.excli.de/index.php/excli/article/view/710

Issue

Vol. 13 (2014)

Section

Original articles

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