The obesity paradox is not observed in chronic heart failure patients with metabolic syndrome

Authors

  • Taro Narumi Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
  • Tetsu Watanabe Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
  • Shinpei Kadowaki Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
  • Yoichiro Otaki Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
  • Yuki Honda Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
  • Satoshi Nishiyama Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
  • Hiroki Takahashi Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
  • Takanori Arimoto Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
  • Tetsuro Shishido Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
  • Takuya Miyamoto Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
  • Isao Kubota Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan

Keywords:

chronic heart failure, obesity paradox, metabolic syndrome, prognosis

Abstract

Introduction: Although being overweight or obese is a risk factor for cardiovascular disease, obese subjects often live longer than their lean peers, and this is known as the obesity paradox. We investigated the impact of obesity on cardiac prognosis in chronic heart failure (CHF) patients, with or without metabolic syndrome.

Design and Methods: We divided 374 consecutive CHF patients into two groups according to their mean body mass index (BMI) and prospectively followed them for 2 years.

Results: There were 126 cardiac events, including 32 cardiac deaths and 94 re-hospitalizations. Kaplan-Meier analysis revealed a significantly lower cardiac event rate in the higher BMI group (log-rank test P < 0.001) in all patients and those patients without metabolic syndrome. There was no association between BMI and cardiac prognosis in patients with metabolic syndrome. Cox hazard analysis revealed that a higher BMI was associated with favorable cardiac outcomes in all patients and patients without metabolic syndrome, after adjusting for confounding factors. However, this finding did not extend to patients with metabolic syndrome.

Conclusions: The advantages of obesity are not found in CHF patients with metabolic syndrome.

Published

2014-05-12

How to Cite

Narumi, T., Watanabe, T., Kadowaki, S., Otaki, Y., Honda, Y., Nishiyama, S., … Kubota, I. (2014). The obesity paradox is not observed in chronic heart failure patients with metabolic syndrome. EXCLI Journal, 13, 516–525. Retrieved from https://www.excli.de/index.php/excli/article/view/718

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Section

Original articles

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