Epigenetics in diagnosis, prognostic assessment and treatment of cancer: an update

Authors

  • Eleftheria Hatzimichael Department of Haematology, University Hospital of Ioannina, Ioannina, Greece
  • Konstantinos Lagos Department of Haematology, University Hospital of Ioannina, Ioannina, Greece
  • Van Ren Sim Dundee Cancer Center, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
  • Evangelos Briasoulis Department of Haematology, University Hospital of Ioannina, Ioannina, Greece
  • Tim Crook Dundee Cancer Center, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK

Keywords:

epigenetics, methylation, acetylation, diagnosis, treatment, cancer, hematological malignancies, hypomethylating agents

Abstract

Cancer cells contain multiple genetic and epigenetic changes. The relative specificity of many epigenetic changes for neoplastic cells has allowed the identification of diagnostic, prognostic and predictive biomarkers for a number of solid tumors and hematological malignancies. Moreover, epigenetically-acting drugs are already in routine use for cancer and numerous additional agents are in clinical trials. Here, we review recent progress in the development and application of epigenetic strategies for the diagnosis, risk stratification and treatment of cancer.

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Published

2014-08-26

How to Cite

Hatzimichael, E., Lagos, K., Sim, V. R., Briasoulis, E., & Crook, T. (2014). Epigenetics in diagnosis, prognostic assessment and treatment of cancer: an update. EXCLI Journal, 13, 954>-976>. Retrieved from https://www.excli.de/index.php/excli/article/view/753

Issue

Vol. 13 (2014)

Section

Review articles

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