Tumor suppressive effects of the pleiotropically acting miR-195 in colorectal cancer cells

Authors

  • Zahra Forouzan Jahromi Department of Stem Cells and Regenerative Medicine, Institute for Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran
  • Arash Javeri Department of Stem Cells and Regenerative Medicine, Institute for Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran, Pajoohesh Blvd., P.O. Box: 14965-161, Tehran, Iran, Phone: +982144787381. Fax: +982144787399; E-mail: arashj@nigeb.ac.ir
  • Masoumeh Fakhr Taha Department of Stem Cells and Regenerative Medicine, Institute for Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran, Pajoohesh Blvd., P.O. Box: 14965-161, Tehran, Iran, Phone: +982144787381. Fax: +982144787399; E-mail: mftaha@nigeb.ac.ir

DOI:

https://doi.org/10.17179/excli2019-1166

Keywords:

colorectal cancer, miR-195, EMT, angiogenesis, apoptosis

Abstract

Downregulation of miR-195 in colorectal cancer tissues has been reported in several studies. We investigated the impact exogenous induction of mature miR-195-5p on some malignant features of human colorectal cancer cells. Caco-2 and SW480 human colon cancer cell lines were transfected with a synthetic miR-195-5p mimic. Exogenous induction of miR-195-5p suppressed multiple mediators of invasion and angiogenesis in colorectal cancer cells and increased the apoptotic cell population in both cell lines. Also, migration of both cell lines was significantly compromised after miR-195 transfection. Our results are indicating a strong tumor suppressive role for miR-195 in human colorectal cancer.

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Published

2019-04-09

How to Cite

Forouzan Jahromi, Z., Javeri, A., & Fakhr Taha, M. (2019). Tumor suppressive effects of the pleiotropically acting miR-195 in colorectal cancer cells. EXCLI Journal, 18, 243–252. https://doi.org/10.17179/excli2019-1166

Issue

Vol. 18 (2019)

Section

Original articles

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