Nitroxoline: a potent antimicrobial agent against multidrug resistant Enterobacteriaceae

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Rungrot Cherdtrakulkiat
Ratana Lawung
Sunanta Nabu
Srisurang Tantimavanich
Nujarin Sinthupoom
Supaluk Prachayasittikul
Virapong Prachayasittikul

Abstract

Antimicrobial resistance has become a prime global concern. An ability of the microbes to produce enzymes to destroy antimicrobial drugs is one of the well-known mechanisms underlying the resistance. 8-Hydroxyquinoline (8HQ) and derivatives were reported to exert diverse biological effects such as antimicrobial, antioxidant and antineurodegenerative activities. Herein, 8HQ (1), nitroxoline (NQ, 2) and 7-Br-8HQ (3) were investigated for antimicrobial activity against Enterobacteriaceae including extended spectrum β-lactamase (ESBL)-producing and carbapenemase-producing strains as well as the effect of metal ions. These compounds (1-3) displayed the great antimicrobial activity against fifty-eight bacterial isolates of Escherichia coli, Providencia rettgeri and Klebsiella pneumoniae, in which NQ (2) exerted the highest antimicrobial activity with a MIC50 of 42.04 mM (8 µg/mL) and MBC50 of 168.28 mM (32 µg/mL). The MIC values of NQ (2) and 7-Br-8HQ (3) were significantly increased in the presence of Cu2+ and Fe3+. This finding reveals that NQ could be an effective compound to be further developed as an antimicrobial agent for combating Enterobacteriaceae infections.

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How to Cite
Cherdtrakulkiat, R., Lawung, R., Nabu, S., Tantimavanich, S., Sinthupoom, N., Prachayasittikul, S., & Prachayasittikul, V. (2019). Nitroxoline: a potent antimicrobial agent against multidrug resistant Enterobacteriaceae. EXCLI Journal, 18, 445-453. https://doi.org/10.17179/excli2019-1378
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Original articles