Nitroxoline: a potent antimicrobial agent against multidrug resistant Enterobacteriaceae

Authors

  • Rungrot Cherdtrakulkiat Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand
  • Ratana Lawung Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand
  • Sunanta Nabu Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand
  • Srisurang Tantimavanich Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand
  • Nujarin Sinthupoom Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand
  • Supaluk Prachayasittikul Center of Data Mining and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand
  • Virapong Prachayasittikul Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand, E-mail: virapong.pra@mahidol.ac.th, Phone: (662) 441-4376; Fax: (662) 441-4380

DOI:

https://doi.org/10.17179/excli2019-1378

Keywords:

Enterobacteriaceae, multidrug resistance, antimicrobial activity, 8-hydroxyquinoline, nitroxoline

Abstract

Antimicrobial resistance has become a prime global concern. An ability of the microbes to produce enzymes to destroy antimicrobial drugs is one of the well-known mechanisms underlying the resistance. 8-Hydroxyquinoline (8HQ) and derivatives were reported to exert diverse biological effects such as antimicrobial, antioxidant and antineurodegenerative activities. Herein, 8HQ (1), nitroxoline (NQ, 2) and 7-Br-8HQ (3) were investigated for antimicrobial activity against Enterobacteriaceae including extended spectrum β-lactamase (ESBL)-producing and carbapenemase-producing strains as well as the effect of metal ions. These compounds (1-3) displayed the great antimicrobial activity against fifty-eight bacterial isolates of Escherichia coli, Providencia rettgeri and Klebsiella pneumoniae, in which NQ (2) exerted the highest antimicrobial activity with a MIC50 of 42.04 mM (8 µg/mL) and MBC50 of 168.28 mM (32 µg/mL). The MIC values of NQ (2) and 7-Br-8HQ (3) were significantly increased in the presence of Cu2+ and Fe3+. This finding reveals that NQ could be an effective compound to be further developed as an antimicrobial agent for combating Enterobacteriaceae infections.

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Published

2019-06-27

How to Cite

Cherdtrakulkiat, R., Lawung, R., Nabu, S., Tantimavanich, S., Sinthupoom, N., Prachayasittikul, S., & Prachayasittikul, V. (2019). Nitroxoline: a potent antimicrobial agent against multidrug resistant Enterobacteriaceae. EXCLI Journal, 18, 445–453. https://doi.org/10.17179/excli2019-1378

Issue

Vol. 18 (2019)

Section

Original articles

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