@article{Joukar_Najafipour_Mirzaeipour_Nasri_Ahmadi_Badinloo_2013, title={Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury}, volume={12}, url={https://www.excli.de/index.php/excli/article/view/1136}, abstractNote={<p>Administration of semelil (ANGIPARS™) has been successful in the treatment of diabetic foot ulcer. Considering the improvement of blood flow and anti-inflammatory effect that are attributed to this drug, we investigated its effect on cardiovascular performance in rabbits with isoproterenol (ISO) induced myocardial injury. Animal groups included: control group; ISO group, received ISO 50 mg/kg s.c. for two consecutive days; S1+ISO, S5+ISO and S10+ISO groups, received semelil 1, 5, and 10 mg/kg/day i.p. respectively, 30 min before ISO. On the 3<sup>rd</sup> day, electrocardiogram (ECG) and hemodynamic parameters were recorded; blood samples were taken and hearts were removed for lab investigations.</p><p>ISO induced heart injury, ECG disturbance, raise of cardiac troponin I and significant decrease in LVSP (p<0.05), +dp/dt max (p<0.01), -dp/dt max (p<0.05) along with increase of LVEDP (p<0.01). Semelil had no significant effects on ECG and plasma cardiac troponin I. Impairment of +dp/dt max and -dp/dt max was significantly improved in S5+ISO and S10+ISO groups (P<0.05 versus ISO). In addition, LVSP and LVEDP was somewhat recovered in these groups, although semelil (1 mg/kg/day) to some extent exacerbated the myocardial lesions induced by ISO (P<0.05). </p><p>Therefore, in stressful conditions, semelil may improve myocardial contractility; however, it may aggravate the severity of injury.</p>}, journal={EXCLI Journal}, author={Joukar, Siyavash and Najafipour, Hamid and Mirzaeipour, Fateme and Nasri, Hamidreza and Ahmadi, Mahboubeh Yeganeh Haj and Badinloo, Marziyeh}, year={2013}, month={Feb.}, pages={122–129} }