@article{Kangarlu-Haghighi_Oryan_Nasehi_Zarrindast_2015, title={The effect of BLA GABA(A) receptors in anxiolytic-like effect and aversive memory deficit induced by ACPA}, volume={14}, url={https://www.excli.de/index.php/excli/article/view/571}, DOI={10.17179/excli2015-201}, abstractNote={<p>The roles of GABAergic receptors of the Basolateral amygdala (BLA) in the cannabinoid CB1 receptor agonist (arachydonilcyclopropylamide; ACPA)-induced anxiolytic-like effect and aversive memory deficit in adult male mice were examined in elevated plus-maze task. Results showed that pre-test intra-peritoneal injection of ACPA induced anxiolytic-like effect (at dose of 0.05 mg/kg) and aversive memory deficit (at doses of 0.025 and 0.05 mg/kg). The results revealed that Pre-test intra-BLA infusion of muscimol (GABA<sub>A</sub> receptor agonist; at doses of 0.1 and 0.2 µg/mouse) or bicuculline (GABA<sub>A</sub> receptor antagonist; at all doses) impaired and did not alter aversive memory, respectively. All previous GABA agents did not have any effects on anxiety-like behaviors. Interestingly, pretreatment with a sub-threshold dose of muscimol (0.025 µg/mouse) and bicuculline (0.025 µg/mouse) did not alter anxiolytic-like behaviors induced by ACPA, while both drugs restored ACPA-induced amnesia. Moreover, muscimol or bicuculline increased and decreased ACPA-induced locomotor activity, respectively. Finally the data may indicate that BLA GABA<sub>A </sub>receptors have critical and different roles in anxiolytic-like effect, aversive memory deficit and locomotor activity induced by ACPA.</p>}, journal={EXCLI Journal}, author={Kangarlu-Haghighi, Katayoon and Oryan, Shahrbanoo and Nasehi, Mohammad and Zarrindast, Mohammad-Reza}, year={2015}, month={May}, pages={613–626} }