@article{Xiao_Wang_Dai_Zhu_2014, title={Anti-inflammatory activity and chemical composition of the essential oils from Senecio flammeus}, volume={13}, url={https://www.excli.de/index.php/excli/article/view/740}, abstractNote={<p>Many species from <i>Senecio</i> genus have been used in traditional medicine, and their pharmacological activities have been demonstrated. This study investigated the chemical composition and anti-inflammatory activities of essential oils from <i>Senecio flammeus</i>. A total of 48 components representing 98.41 % of the total oils were identified. The main compounds in the oils were α-farnesene (11.26 %), caryophyllene (8.69 %), n-hexadecanoic acid (7.23 %), and α-pinene (6.36 %). The anti-inflammatory activity of the essential oils was evaluated in rodents (10–90 mg/kg bw) in classical models of inflammation [carrageenan-induced paw edema, 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced ear edema, and cotton pellet-induced granuloma]. The essential oils at doses of 10, 30, and 90 mg/kg bw significantly reduced carrageenan-induced paw edema by 17.42 % (P < 0.05), 52.90 % (P < 0.05), and 66.45 % (P < 0.05) 4 h after carrageenan injection, respectively, and significantly reduced myeloperoxidase activity (P < 0.05). The essential oils (10, 30, and 90 mg/kg) also produced a significant dose-dependent response to reduce TPA-induced ear edema by 20.27 % (P < 0.05), 33.06 % (P < 0.05), and 53.90 % (P < 0.05), respectively. The essential oils produced significant dose-response anti-inflammatory activity against cotton pellet-induced granuloma that peaked at the highest dose of 90 mg/kg (49.08 % wet weight and 47.29 % dry weight). Results demonstrate that the essential oils of <i>S. flammeus</i> were effective in the treatment of both acute and chronic inflammatory conditions, thereby supporting the traditional use of this herb.</p>}, journal={EXCLI Journal}, author={Xiao, Kai-Jun and Wang, Wen-Xia and Dai, Jia-Li and Zhu, Liang}, year={2014}, month={Jul.}, pages={782–791} }