@article{Chaudhary_Sood_Das_Kaur_Mahajan_Gulati_Singh_2014, title={Synthesis of novel antimicrobial aryl himachalene derivatives from naturally occurring himachalenes}, volume={13}, url={https://www.excli.de/index.php/excli/article/view/774}, abstractNote={<p> Five new 2,9,9-trimethyl-6,7,8,9-tetrahydro-benzocyclohepten-5-ylidene-amine derivatives (<b>16a</b>-<b>16e</b>) were synthesized from <i>α</i>-dehydro-<i>ar</i>-himachalene (<b>11</b>) that was originally prepared from an isomeric mixture of <i>α</i>,<i> β </i>and <i>γ</i> himachalenes (<b>10</b>), the abundant sesquiterpenes of <i>Cedrus deodara</i> essential oil. In addition, different aryl himachalenes derivatives (<b>9</b>, <b>12, 14 </b>and<b> 15</b>) were also formed from <b>11</b>. The structures of the synthesized compounds were confirmed on the basis of their NMR, IR and mass spectral data. The prepared compounds were tested against a group of sixteen organisms including gram positive and gram negative bacterial and fungal strains. The introduction of a series of substituted imine groups into aryl himachalenes at 5<sup>th</sup> position (<b>16a</b>-<b>16e</b>) enhanced antimicrobial activity as compared to the aromatized derivatives (<b>9</b>, <b>12, 14 </b>and<b> 15</b>) against gram-positive bacteria <i>Bacillus subtilis</i>, <i>Micrococcus luteus</i> and <i>Staphylococcus aureus</i>, and mycotoxigenic fungi <i>Aspergillus</i> <i>parasiticus</i>, <i>A</i>. <i>ochraceous</i> and <i>A</i>. <i>sydowii</i>. graphical Abstract, Figure 1</p>}, journal={EXCLI Journal}, author={Chaudhary, Abha and Sood, Swati and Das, Pralay and Kaur, Pushpinder and Mahajan, Isha and Gulati, Arvind and Singh, Bikram}, year={2014}, month={Nov.}, pages={1216–1225} }