TY - JOUR AU - Kim, Min-Jin AU - Yang, Kyong-Wol AU - Kim, Sang Suk AU - Park, Suk Man AU - Park, Kyung Jin AU - Kim, Kwang Sik AU - Choi, Young Hun AU - Cho, Kwang Keun AU - Lee, Nam Ho AU - Hyun, Chang-Gu PY - 2013/11/07 Y2 - 2024/03/29 TI - Chemical composition and anti-inflammatory effects of essential oil from Hallabong flower JF - EXCLI Journal JA - EXCLI J. VL - 12 IS - 0 SE - Original articles DO - UR - https://www.excli.de/index.php/excli/article/view/1204 SP - 933-942 AB - <p>A number of essential oils derived from plants are claimed to have several medicinal functions, including anti-cancer and anti-inflammation effects. However, the chemical composition and biological activities of flower-derived components have not been sufficiently characterized. Therefore, we investigated the composition of essential oils from Hallabong flower [(<i>Citrus unshiu</i> Marcov × <i>Citrus sinensis</i> Osbeck) × <i>Citrus reticulata</i> Blanco] and their anti-inflammatory effects. Hydro-distilled essential oils (HEOs) were analyzed using gas chromatography-mass spectrometry (GC-MS). In total, 21 components were identified, representing more than 98 % of the oils, with sabinene (34.75 %), linalool (14.77 %), β-ocimene (11.07 %), 4-terpineol (9.63 %), l-limonene (5.88 %), and γ-terpinene (4.67 %) as the main components. In the present study, we also investigated the anti-inflammatory effects of HEOs on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. HEOs were found to inhibit nitric oxide (NO) and prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) production and to suppress the LPS-induced expression of cyclooxygenase-2 (COX-2) protein. In addition, HEOs downregulated the production of the inflammatory cytokines, tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β (IC<sub>50</sub> values are 0.05 %, 0.02 %, and 0.01 %, respectively). On the basis of these results, we suggest that HEOs can be considered potential anti-inflammatory candidates for therapeutic use in humans.</p> ER -