TY - JOUR AU - Grosch, Melanie AU - Fuchs, Jennifer AU - Bösl, Michael AU - Winterpacht, Andreas AU - Tagariello, Andreas PY - 2013/11/20 Y2 - 2024/03/29 TI - Selenoprotein M is expressed during bone development JF - EXCLI Journal JA - EXCLI J. VL - 12 IS - 0 SE - Original articles DO - UR - https://www.excli.de/index.php/excli/article/view/1207 SP - 967-979 AB - <p>25 selenoproteins that contain selenium, incorporated as selenocysteine (Sec), have been identified to date. Selenoprotein M (SELM) is one of seven endoplasmic reticulum (ER)-resident, Sec-containing proteins that may be involved in posttranslational processing of proteins and maintenance of ER function. Since <i>SELM</i> was overrepresented in a cartilage- and bone-specific expressed sequence tag (EST) library, we further investigated the expression pattern of <i>Selm</i> and its possible biological function in the skeleton. RNA <i>in situ</i> hybridization of <i>Selm</i> in chicken and mice of different developmental stages revealed prominent expression in bones, specifically in osteoblast, and in tendons. This result suggests that SELM functions during bone development, where it is possibly involved in the processing of secreted proteins.</p> ER -