TY - JOUR AU - Taurone, Samanta AU - Ralli, Massimo AU - Artico, Marco AU - Madia, Valentina Noemi AU - Scarpa, Susanna AU - Nottola, Stefania Annarita AU - Maconi, Antonio AU - Betti, Marta AU - Familiari, Pietro AU - Nebbioso, Marcella AU - Costi, Roberta AU - Micera, Alessandra PY - 2022/03/01 Y2 - 2024/03/29 TI - Oxidative stress and visual system: a review JF - EXCLI Journal JA - EXCLI J. VL - 21 IS - SE - Review articles DO - 10.17179/excli2022-4663 UR - https://www.excli.de/index.php/excli/article/view/4663 SP - 544-553 AB - <p class="Abstract"><span lang="EN-US">Different types of tissues respond differently to the action of oxidative stress. The visual system is very sensitive to oxidative action due to continuous exposure to light. In consideration of the growing interest of scientific studies towards various compounds endowed with antioxidant and anti-inflammatory properties, we performed a review of the literature focusing on the use of some antioxidant molecules for the treatment of conditions affecting the visual system. In this study, we focused on the ability of two antioxidant agents, the small molecule α-lipoic acid (ALA) and the enzyme superoxide dismutase (SOD), to influence the neurodegenerative physiological processes related to aging and oxidative stress affecting the ocular segment. The literature data report that ALA and SOD can protect against neurodegenerative effects both the optic nerve and retina and, if administered together, they are able to lower the levels of oxidative stress, thus preventing neurodegeneration and reducing the apoptotic process.</span></p> ER -