TY - JOUR AU - Yanokura, Megumi AU - Banno, Kouji AU - Iida, Miho AU - Irie, Haruko AU - Umene, Kiyoko AU - Masuda, Kenta AU - Kobayashi, Yusuke AU - Tominaga, Eiichiro AU - Aoki, Daisuke PY - 2015/02/02 Y2 - 2024/03/28 TI - MicroRNAS in endometrial cancer: recent advances and potential clinical applications JF - EXCLI Journal JA - EXCLI J. VL - 14 IS - 0 SE - Review articles DO - 10.17179/excli2014-590 UR - https://www.excli.de/index.php/excli/article/view/532 SP - 190-198 AB - <p>Endometrial cancer is a common malignant gynecological tumor, but there are few biomarkers that are useful for early and accurate diagnosis and few treatments other than surgery. However, use of microRNAs (miRNAs) that induces gene downregulation in cells may permit effective and minimally invasive diagnosis and treatment. In endometrial cancer cells, expression levels of miRNAs including miR-185, miR-210 and miR-423 are upregulated and those of miR-let7e, miR-30c and miR-221 are downregulated compared to normal tissues, and these miRNAs are involved in carcinogenesis, invasion and metastasis. miRNAs with expression changes such as miR-181b, miR-324-3p and miR-518b may be used as prognostic biomarkers and transfection of miR-152 may inhibit cancer growth. However, most current studies of miRNAs are at a basic level and further work is needed to establish clinical applications targeting miRNAs.</p> ER -