TY - JOUR AU - Rahmani, Farzad AU - Safavi, Pegah AU - Fathollahpour, Ayda AU - Tanhaye Kalate Sabz, Fatemeh AU - Tajzadeh, Parastoo AU - Arefnezhad, Mohsen AU - Ferns, Gordon A. AU - Hassanian, Seyed Mahdi AU - Avan, Amir PY - 2022/10/18 Y2 - 2024/03/29 TI - The interplay between non-coding RNAs and Wnt/β-catenin signaling pathway in urinary tract cancers: from tumorigenesis to metastasis JF - EXCLI Journal JA - EXCLI J. VL - 21 IS - SE - Review articles DO - 10.17179/excli2022-5348 UR - https://www.excli.de/index.php/excli/article/view/5348 SP - 1273-1284 AB - <p class="Abstract"><span lang="EN-US">Non-coding RNAs (ncRNAs) are emerging as important regulators in various pathological conditions including tumorigenesis, metastasis, and drug resistance in human cancers. Oncogenic or tumor suppressor ncRNAs exert prominent effects on cell proliferation, migration and invasion in cancer cells through modulating various signaling pathways including Wnt/β-catenin. Upregulation of the oncogenic Wnt/β-catenin pathway was reported to be implicated in multiple human cancers including breast, liver, colorectal, and urothelial cancers. Therefore, identifying interactions between ncRNAs and canonical Wnt signaling components may represent novel therapeutic targets for better treatment and management of cancer. In this review, we summarized the recent findings about miRNA/lncRNA-dependent mechanisms that regulate Wnt/β-catenin signaling involved in tumorigenesis and metastasis of urinary tract cancers.</span></p> ER -