EXCLI Journal https://www.excli.de/index.php/excli <center><img class="img-responsive" src="/public/site/images/lindemann/Lucida_logo_neu_geschrieben.PNG" alt="EXCLI Journal Logo"></center> <p>EXCLI Journal publishes original research reports, authoritative reviews and case reports of experimental and clinical sciences.</p> <div class="toggleBox"><input id="toggleContent" name="toggleContent" type="checkbox"> <label class="open" for="toggleContent">More...</label> <label class="close" for="toggleContent">Less...</label> <div> <p><strong>EXCLI Journal </strong>(eISSN 1611-2156)&nbsp;is particularly keen to keep a broad view of science and technology, and therefore welcomes papers which bridge disciplines and may not suit the narrow specialism of other journals. Although the general emphasis is on biological sciences, studies from the following fields are explicitly encouraged:</p> <p>Immunology, toxicology, ergonomics, neurosciences, psychology, occupational medicine, clinical and preclinical studies, drug development, pharmacology, environmental health, chemistry including analytical chemistry, biochemistry, cell biology, genetics, forensic medicine, oncology and cancer research, proteomics, systems biology, hepatology and gastroenterology, aging research, psychiatric research, behavioral sciences.</p> </div> </div> IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund en-US EXCLI Journal 1611-2156 <p>Authors who publish in this journal agree to the following terms:</p> <ul> <li>The authors keep the copyright and grant the journal the right of first publication under the terms of the Creative Commons Attribution license, <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noopener">CC BY 4.0</a>. This licencse permits unrestricted use, distribution and reproduction in any medium, provided that the original work is properly cited.</li> <li>The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.</li> <li>Because the advice and information in this journal are believed to be true and accurate at the time of publication, neither the authors, the editors, nor the publisher accept any legal responsibility for any errors or omissions presented in the publication. The publisher makes no guarantee, express or implied, with respect to the material contained herein.</li> <li>The authors can enter into additional contracts for the non-exclusive distribution of the journal's published version by citing the initial publication in this journal (e.g. publishing in an institutional repository or in a book).</li> </ul> Psychosocial factors associated with resilience among Iranian nurses during COVID-19 outbreak https://www.excli.de/index.php/excli/article/view/4126 <p>In the face of COVID-19, healthcare workers need to cope with the ongoing stressors at play and keep psychological distress at a minimum level. This study examined the psychosocial and demographic factors associated with nurse's resilience in the hospitals of Ahvaz that is one of the top cities infected with COVID-19 in Iran. The present cross-sectional study was conducted on 387 Iranian nurses in Ahvaz city. For data collection purposes, three online questionnaires (including Copenhagen Psychosocial, Demographic, and Connor–Davidson Resilience Scale) were distributed among the participants. The mean resilience score was equal to 61.8±14.8 for 387 nurses. Resilience had a statistically significant negative correlation with quantitative demand (r=-0.273, <em>P</em>&lt;0.008), work pace (r=-0.262, <em>P</em>&lt;0.011), emotional demand (r=-0.226, <em>P</em>&lt;0.030), stress (r=-0.458, <em>P</em>&lt;0.000), and burnout (r=-0.287, <em>P</em>&lt;0.005). Multiple linear regression analysis indicated that stress, job satisfaction, burnout and age were the main predictors of nurses' resilience during the (COVID-19) pandemic (R<sup>2</sup>=0.45). We identified psychosocial and demographic predictive factors that may contribute to greater resilience among nurses during the COVID-19 outbreak. The findings of this study can be used to implement psychosocial interventions to amplify the resilience of medical staff during the COVID-19 outbreak.</p> Davood Afshari maryam Nourollahi-darabad1 Niloufar Chinisaz Copyright (c) 20 Correlation between gut flora and plasma lipid in hypothyroidism during pregnancy https://www.excli.de/index.php/excli/article/view/4125 <p><strong>Objective:</strong>To investigate the correlation between gut microbiota and plasma lipid metabolites in patients with hypothyroidism during pregnancy.</p> <p><strong>Methods:</strong>Gut microflora characteristics was surveyed using 16S&nbsp;rRNA sequencing approach in 55 pregnant women (27 with hypothyroidism and 28 normal controls).Untargeted liquid chromatography-mass spectrometry technology(LC-MS) was used to compare plasma lipid metabolite differences between the two groups of pregnant women,followed by Spearman correlation analysis between gut microbiota and plasma lipid metabolites and serological indicators.</p> <p><strong>Results:</strong>1.The levels of C-reactive protein (CRP) of pregnant women in the hypothyroidism group were elevated(p=0.018), and for their children, neonatal head circumference and body length were decreased(p<0.001). 2.The 16S rRNA and Prediction of flora function results indicated that the abundance of Prevotella, Haemophilus, and Roseburia increased,while that of Blautia decreased in the hypothyroidism group(p &lt; 0.05),and the pathways of flagellar assembly and primary immunodeficiency in the hypothyroidism group were dominant. 3.There were 42 differential metabolites in these two groups(VIP&gt;1.0, p&lt;0.05),such as phosphatidylethanolamine(PE),phosphatidylinositol (PI) and sphingomyelin(SM),and 7 enrichment KEGG(Kyoto Encyclopedia of Genes and Genomes) metabolic pathways of differential metabolites,such as glycerol phospholipids metabolism,autophagy,etc. 4.The abundance of Prevotella was positively correlated with CRP; Roseburia was positively correlated with PI; Blautia was positively correlated with SM and negatively correlated with PE.</p> <p><strong>Conclusion:</strong>&nbsp;The gut microbiota-host interaction may participate in the occurrence of hypothyroidism during pregnancy through inflammatory immune responses and lipid metabolites in the body. The interaction between Blautia and SM may be a potential target for further studies on the pathogenesis of hypothyroidism during pregnancy.</p> Yanjun Cai Yajuan Xu Yanjie Ban Jingjing Li Zongzong Sun Miao Zhang Biao Wang Xiaofeng Hou Yingqi Hao Qian Ouyang Bo Wu Mengqi Wang Wentao Wang Copyright (c) 20 Prospects and challenges of growth factor-loaded electrospun wound dressings for diabetic wound healing: a review https://www.excli.de/index.php/excli/article/view/4123 <p>Impaired wound healing is of the conspicuous characteristics of diabetic mellitus disease. Reduced blood flow, poor immune responses, infection, endothelial dysfunction, elevated levels of reactive oxygen species, and metabolic disorders cause wounds to heal more slowly in these patients. Previous studies have reported useful impacts of growth factors in management of&nbsp;&nbsp; such wounds. However, due to their short half-life and the need for high dose in case of systemic administration, a suitable delivery platform with sustained release profile may boost their healing potential. Controlled and localized delivery of growth factors via electrospun nanofibers have been extensively explored in previous studies. The electrospinning method; although not new, has been proven extremely effective in developing advanced drug delivery systems due to their structural advantages, high encapsulation efficacy, tunability, and high surface to volume ratio. In the current review, careful integration of current research regarding the applications of growth factors delivery through electrospun fibers in diabetic wounds healing has been done. This review will not only give an insight into the current updates, but will also highlight the future perspectives and challenges.</p> Yunwu Zhang Tingting Deng Jingsong Luo Qi Zhang Copyright (c) 20