Letter to the editor

Recent developments in animal sciences

Seddik Hammad1[*], Isabelle Sobor2, Mohammed F. Abdallah3, Ahmed A.A. Abdel-Wareth4, Mohammad S. Al-Aboody5, Mosaab A. Omar5

1Department of Forensic Medicine and Veterinary Toxicology, Faculty of Veterinary Medicine, South Valley University, Qena-Egypt

2Department of Environmental Toxicology, Faculty of Biology, University Essen-Duisburg, Essen-Germany

3Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Hacettepe University, Sihyyie/Ankara-Türkiye

4Animal Nutrition Group, Institute of Animal Science, University of Bonn, Germany

5Department of Medical Laboratories, College of Science, Majmaah University, AlZulfi-KSA

EXCLI J 2015;14:Doc611


Dear Editor,

Recently, a new journal, JEAAS (Journal of Experimental and Applied Animal Sciences) has been launched. The goal of this new interdisciplinary journal is to advance the field of animal sciences. A particular focus is the establishment and application of animal models for basic and clinical research (Intzoglou et al., 2014[13]; Graham et al., 2014[7]; Musk et al., 2014[18]; Rezaei et al., 2014[19]; Bénardeau et al., 2013[1]; Deluzurieux et al., 2013[3]). Particularly, the advent of transgenic and knockout technologies together with the generation of humanized animals (Hammad et al., 2013[10]) opens exciting possibilities. A second field of interest is traditional and applied animal sciences including farm animals, animal nutrition and related fields of veterinary medicine (Mallaiah et al., 2014[16]; Soriano-Úbeda et al., 2013[21]; Mishra et al., 2013[17]; Zarrindast et al., 2013[22]; Ikewuchi et al., 2013[12]).

A currently particularly active research field is the establishment of in vitro systems for applications in pharmacology and toxicology (Kim et al., 2015[14]; Godoy et al., 2013[6]; Zellmer et al., 2010[23]; Drasdo et al., 2014[4]; Grinberg et al., 2014[8]; Schug et al., 2013[20]; Krug et al., 2013[15]). A limitation of in vitro data is that comprehensive studies on the in vivo relevance of responses observed in vitro are rare (Bolt et al., 2014[2]; Ghallab and Bolt, 2014[5]; Hammad et al., 2014[11]; Hammad, 2013[9]). Therefore, JEAAS particularly welcomes studies that compare mechanisms observed in in vitro systems to the corresponding processes in organs or organisms. We hope that JEAAS will play a constructive role in this field of research.



1. Bénardeau A, Riboulet W, Albertini M, Gomez MF. Animal models of metabolic syndrome and associated co-morbidities. JEAAS. 2013;1:152-3.
2. Bolt HM, Ahmed H, Hammad S. Current research on cell death mechanisms. Arch Toxicol. 2014;88:2079-82.
3. Deluzurieux M, Desjardins I, Nolf M, Guidi E, Depecker M, Cadoré J-L. Endoscopic analysis of guttural pouch opening in horses. JEAAS. 2013;1:10-24.
4. Drasdo D, Bode J, Dahmen U, Dirsch O, Dooley S, Gebhardt R, et al. The virtual liver: state of the art and future perspectives. Arch Toxicol. 2014;88:2071-5.
5. Ghallab A, Bolt HM. In vitro systems: current limitations and future perspectives. Arch Toxicol. 2014;8:2085-7.
6. Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, et al. Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol. 2013;87:1315-530.
7. Graham WA, Kwiecien JM, Nesathurai S. Noninvasive motor evoked potentials with surface stimulation in rodents. JEAAS. 2014;1:182-5.
8. Grinberg M, Stöber RM, Edlund K, Rempel E, Godoy P, Reif R, et al. Toxicogenomics directory of chemically exposed human hepatocytes. Arch Toxicol. 2014;88:2261-87.
9. Hammad S. Advances in 2D and 3D in vitro systems for hepatotoxicity testing. EXCLI J. 2013;12:993-6.
10. Hammad S, Marchan R, Hengstler JG. Cutting-edge topics in research on animal sciences. JEAAS. 2013;1:1-3.
11. Hammad S, Omar MA, Abdel-Wareth AAA, Ahmed H. Pitfalls of in vitro systems: why we still need animal experiments? JEAAS. 2014;1:271-2.
12. Ikewuchi JC, Ikewuchi CC, Ifeanacho MO, Igboh NM, Ijeh II, Ihunwo SA. Hypocholesterolemic effect of aqueous extract of the rhizomes of Sansevieria liberica on salt-loaded rats. JEAAS. 2013;1:56-66.
13. Intzoglou KS, Mastrokalos DS, Korres DS, Donta I, Lelovas P, Tziakou V, et al. Synthetic or autologous plugs for the repair of osteochondral rabbit knee defects: A comparative study. JEAAS. 2014;1:229-40.
14. Kim JY, Fluri DA, Marchan R, Boonen K, Mohanty S, Singh P,et al. 3D spherical microtissues and microfluidic technology for multi-tissue experiments and analysis. J Biotechnol. 2015 [Epub ahead of print]. doi: 10.1016/j.jbiotec.2015.01.003.
15. Krug AK, Kolde R, Gaspar JA, Rempel E, Balmer NV, Meganathan K, et al. Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013;87:123-43.
16. Mallaiah P, Sudhakara G, Srinivasulu N, Sasi Bhusana RB, Saralakumari D. Preventive effect of Phyllanthus amarus on high fructose diet induced renal damage in male wistar rats. JEAAS. 2014;1:186-98.
17. Mishra D, Joshi S, Sah ML. Analgesic activity of ethyl acetate fraction of Leucas hyssopifolia Benth. JEAAS. 2013;1:4-9.
18. Musk GC, He B, Gaal T. Hyperkalemia in pigs during anesthesia for laparoscopic renal transplantation surgery. JEAAS. 2014;1:273-83.
19. Rezaei F, Kaka G, Sadraie SH, Azarnia M, Salamatmanesh SM. Effects of aspirin on histomorphometrical changes of fetal kidney in rat. JEAAS. 2014;1:290-300.
20. Schug M, Stöber R, Heise T, Mielke H, Gundert-Remy U, Godoy P, et al. Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes. Arch Toxicol. 2013;87:337-45.
21. Soriano-Úbeda C, Matás C, García-Vázquez FA. An overview of swine artificial insemination: Retrospective, current and prospective aspects. JEAAS. 2013;1:67-97.
22. Zarrindast MR, Ahmadi H, Nasehi M. Interaction of GABA (A) system in the nucleus accumbens ahell with ACPA on anxiety-like behaviors in Wistar male rat. JEAAS. 2013;1:44-55.
23. Zellmer S, Schmidt-Heck W, Godoy P, Weng H, Meyer C, Lehmann T, et al. Transcription factors ETF, E2F, and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes. Hepatology. 2010;52:2127–36.

[*] Corresponding Author:

Dr. med. vet. Seddik Hammad, Department of Forensic Medicine and Veterinary Toxicology, Faculty of Veterinary Medicine, South Valley University, Qena-Egypt, eMail: seddik.hammad@vet.svu.edu.eg