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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">EXCLI J</journal-id>
      <journal-title>EXCLI Journal</journal-title>
      <issn pub-type="epub">1611-2156</issn>
      <publisher>
        <publisher-name>Leibniz Research Centre for Working Environment and Human Factors</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">2015-664</article-id>
	  		<article-id pub-id-type="doi">10.17179/excli2015-664</article-id>
      <article-id pub-id-type="pii">Doc1</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Letter to the editor</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>An update on the potential health benefits of carotenes </article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Kim</surname>
            <given-names>Jae Kwang</given-names>
          </name>
          <xref ref-type="corresp" rid="COR1">&#x0002a;</xref>
          <xref ref-type="aff" rid="A1">1</xref>
        </contrib>
      </contrib-group>
      <aff id="A1">
        <label>1</label>Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 406-772, Korea</aff>
      <author-notes>
        <corresp id="COR1">*To whom correspondence should be addressed: Jae Kwang Kim, Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 406-772, Korea; Phone: +82-32-835-8241, Fax: +82-32-835-0763, E-mail: <email>kjkpj@inu.ac.kr</email></corresp>
      </author-notes>
      <pub-date pub-type="epub">
        <day>06</day>
        <month>01</month>
        <year>2016</year>
      </pub-date>
      <pub-date pub-type="collection">
        <year>2016</year>
      </pub-date>
      <volume>15</volume>
      <fpage>1</fpage>
	  <lpage>4</lpage>
      <history>
        <date date-type="received">
          <day>03</day>
          <month>11</month>
          <year>2015</year>
        </date>
        <date date-type="accepted">
          <day>07</day>
          <month>12</month>
          <year>2015</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>Copyright &#xA9; 2016 Kim</copyright-statement>
        <copyright-year>2016</copyright-year>
        <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/">
          <p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/) You are free to copy, distribute and transmit the work, provided the original author and source are credited.</p>
        </license>
      </permissions>
      <self-uri xlink:href="http://www.excli.de/vol15/Kim_06012016_proof.pdf">This article is available from http://www.excli.de/vol15/Kim_06012016_proof.pdf</self-uri>
    </article-meta>
  </front>
  <body>
    <sec>
      <title>Dear Editor,</title><p>Carotenes, which are yellow-orange pigments, are a class of related organic compounds classified as hydrocarbons, more specifically as terpenoids, with the molecular formula C40H56. Plants, fungi, and photosynthetic bacteria synthesize carotenes, while animals must obtain them as a dietary nutrient (Vrolijk et al., 2015[<xref ref-type="bibr" rid="R30">30</xref>]). Plants are capable of synthesizing several isomers of carotene. Alpha-carotene (&#x3B1;-carotene) and beta-carotene (&#x3B2;-carotene) are the two primary isomers found in plants; other carotene isomers found in plants are gamma-, delta-, epsilon-, and zeta-carotene (&#x3B3;, &#x3B4;, &#x3B5;, and &#x3B6;-carotene) (Hammond and Renzi, 2013[<xref ref-type="bibr" rid="R9">9</xref>]). &#x3B2;-Carotene is the most common form of carotene in plants and can be found in yellow, orange, and green leafy vegetables and fruits. It is an important dietary resource and a precursor of vitamin A in humans (Haskell, 2012[<xref ref-type="bibr" rid="R12">12</xref>]; Tang, 2012[<xref ref-type="bibr" rid="R29">29</xref>]; Sommer and Vyas, 2012[<xref ref-type="bibr" rid="R28">28</xref>]).</p><p>Carotenes show a range of biological activity and health benefits for animals, making it an interesting material for the pharmaceutical, food, and cosmetics industries. We have reviewed the most recent studies on carotenes and its biological and pharmacological activities (Table 1<xref ref-type="fig" rid="T1">(Tab. 1)</xref>) (References in Table 1: Li et al., 2015[<xref ref-type="bibr" rid="R17">17</xref>]; Freitas et al., 2015[<xref ref-type="bibr" rid="R7">7</xref>]; Sluijs et al., 2015[<xref ref-type="bibr" rid="R27">27</xref>]; Hashim et al., 2015[<xref ref-type="bibr" rid="R11">11</xref>]; Das et al., 2015[<xref ref-type="bibr" rid="R5">5</xref>]; Ben Amara et al., 2015[<xref ref-type="bibr" rid="R2">2</xref>]; Schnorr et al., 2014[<xref ref-type="bibr" rid="R25">25</xref>]; Fiorelli et al., 2014[<xref ref-type="bibr" rid="R6">6</xref>]; Lai et al., 2014[<xref ref-type="bibr" rid="R15">15</xref>]; Kasperczyk et al., 2014[<xref ref-type="bibr" rid="R13">13</xref>]; Lim et al., 2014[<xref ref-type="bibr" rid="R18">18</xref>]; Wang et al., 2014[<xref ref-type="bibr" rid="R31">31</xref>]; Kim et al., 2014[<xref ref-type="bibr" rid="R14">14</xref>]; Berti et al., 2014[<xref ref-type="bibr" rid="R3">3</xref>]; Gloria et al., 2014[<xref ref-type="bibr" rid="R8">8</xref>]; Orazizadeh et al., 2014[<xref ref-type="bibr" rid="R22">22</xref>]; Abdul-Hamid and Moustafa, 2014[<xref ref-type="bibr" rid="R1">1</xref>]; Nishida et al., 2014[<xref ref-type="bibr" rid="R21">21</xref>]; Harari et al., 2013[<xref ref-type="bibr" rid="R10">10</xref>]; Bjelakovic et al., 2013[<xref ref-type="bibr" rid="R4">4</xref>]; Lee et al., 2013[<xref ref-type="bibr" rid="R16">16</xref>]; Lin et al., 2013[<xref ref-type="bibr" rid="R20">20</xref>]; Rotenstreich et al., 2013[<xref ref-type="bibr" rid="R24">24</xref>]; Silva et al., 2013[<xref ref-type="bibr" rid="R26">26</xref>]; Lim et al., 2013[<xref ref-type="bibr" rid="R19">19</xref>]; Peng et al., 2013[<xref ref-type="bibr" rid="R23">23</xref>]). </p></sec>
    <sec>
      <title>Acknowledgements</title><p>This work was supported by the Incheon National University Research Grant in 2013.</p></sec>
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    <fig id="T1" position="float">
      <label>Table 1</label>
      <caption><title>Recent studies on carotene and its biological and pharmacological activities</title></caption>
      <graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="EXCLI-15-1-t-001" />
    </fig>
  </floats-wrap>
</article>