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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">EXCLI J</journal-id>
      <journal-title>EXCLI Journal</journal-title>
      <issn pub-type="epub">1611-2156</issn>
      <publisher>
        <publisher-name>Leibniz Research Centre for Working Environment and Human Factors</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">2019-1847</article-id>
      <article-id pub-id-type="doi">10.17179/excli2019-1847</article-id>
      <article-id pub-id-type="pii">Doc950</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Letter to the editor</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Recent updates on daidzein against oxidative stress and cancer</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Rawat</surname>
            <given-names>Sarita</given-names>
          </name>
          <xref ref-type="aff" rid="A1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Pathak</surname>
            <given-names>Sachchidanand</given-names>
          </name>
          <xref ref-type="aff" rid="A1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Gupta</surname>
            <given-names>Gaurav</given-names>
          </name>
          <xref ref-type="corresp" rid="COR1">&#x0002a;</xref>
          <xref ref-type="aff" rid="A1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Singh</surname>
            <given-names>Santosh Kumar</given-names>
          </name>
          <xref ref-type="aff" rid="A1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Singh</surname>
            <given-names>Himmat</given-names>
          </name>
          <xref ref-type="aff" rid="A1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Mishra</surname>
            <given-names>Anurag</given-names>
          </name>
          <xref ref-type="aff" rid="A1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Gilhotra</surname>
            <given-names>Ritu</given-names>
          </name>
          <xref ref-type="aff" rid="A1">1</xref>
        </contrib>
      </contrib-group>
      <aff id="A1">
        <label>1</label>School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India</aff>
      <author-notes>
        <corresp id="COR1">*To whom correspondence should be addressed: Gaurav Gupta, School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India, E-mail: <email>gauravpharma25@gmail.com</email></corresp>
      </author-notes>
      <pub-date pub-type="epub">
        <day>21</day>
        <month>10</month>
        <year>2019</year>
      </pub-date>
      <pub-date pub-type="collection">
        <year>2019</year>
      </pub-date>
      <volume>18</volume>
      <fpage>950</fpage>
      <lpage>954</lpage>
      <history>
        <date date-type="received">
          <day>26</day>
          <month>09</month>
          <year>2019</year>
        </date>
        <date date-type="accepted">
          <day>10</day>
          <month>10</month>
          <year>2019</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>Copyright &#xA9; 2019 Rawat et al.</copyright-statement>
        <copyright-year>2019</copyright-year>
        <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/">
          <p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/) You are free to copy, distribute and transmit the work, provided the original author and source are credited.</p>
        </license>
      </permissions>
      <self-uri xlink:href="https://www.excli.de/index.php/excli/article/view/1605">This article is available from https://www.excli.de/index.php/excli/article/view/1605</self-uri>
    </article-meta>
  </front>
  <body>
    <sec>
      <title>⁯</title><p><bold><italic>Dear Editor,</italic></bold></p><p>Daidzein (7-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one) is a naturally occurring compound commonly found in soybeans and some other legumes.  Daidzein is an isoflavone by nature and isolated from <italic>Pueraria Mirifica</italic>, having category of biologically active secondary metabolites commonly produced in the soybean growth and belong to the group of flavonoids. A number of pharmacological activities have been accounted for daidzein, which includes anti-carcinogenesis, anti-fibrotic, anti-diabetic, cholesterol-lowering and cardiovascular activity. Daidzein pretreatment was found to diminish the seriousness of mucosal damage in a portion subordinate way. Some other therapeutic uses of daidzein are weight reduction, decreasing bowels moment, and inflammation associated with histopathological deformities (Amaral et al., 2017[<xref ref-type="bibr" rid="R1">1</xref>]). Their structure and function are alike to human estrogen, which can play a massive role in the prevention of osteoporosis, cancer, and postmenopausal syndromes. Uses of daidzein in anticancer activity against ovarian cancer are still limited (Meng et al., 2017[<xref ref-type="bibr" rid="R14">14</xref>]). Epidemiological data suggest that increased utilization of soybean in food results in decreased cancer risk. Soybean food is highly recommended in cancer prevention because it has a number of anticarcinogens (Yu et al., 2017[<xref ref-type="bibr" rid="R23">23</xref>]). The potent antioxidant activity of daidzein reported in various <italic>in vitro </italic>and<italic> in vivo </italic>studies was conclusively shown in this literature (Table 1<xref ref-type="fig" rid="T1">(Tab. 1)</xref>; References in Table 1: Amaral et al., 2017[<xref ref-type="bibr" rid="R1">1</xref>]; Atiq et al., 2019[<xref ref-type="bibr" rid="R2">2</xref>]; Budryn et al., 2018[<xref ref-type="bibr" rid="R3">3</xref>]; Chan et al., 2018[<xref ref-type="bibr" rid="R4">4</xref>]; Davis et al., 2001[<xref ref-type="bibr" rid="R5">5</xref>]; Eskra et al., 2019[<xref ref-type="bibr" rid="R6">6</xref>]; Foti et al., 2005[<xref ref-type="bibr" rid="R7">7</xref>]; Gundogdu et al., 2018[<xref ref-type="bibr" rid="R8">8</xref>]; Hua et al., 2018[<xref ref-type="bibr" rid="R9">9</xref>]; Huang et al., 2019[<xref ref-type="bibr" rid="R10">10</xref>]; Karale and Kamath, 2017[<xref ref-type="bibr" rid="R11">11</xref>]; Liang et al., 2018[<xref ref-type="bibr" rid="R12">12</xref>]; Medeiros et al., 2016[<xref ref-type="bibr" rid="R13">13</xref>]; Meng et al., 2017[<xref ref-type="bibr" rid="R14">14</xref>]; Murata et al., 2004[<xref ref-type="bibr" rid="R15">15</xref>]; Park et al., 2016[<xref ref-type="bibr" rid="R16">16</xref>]; Poschner et al., 2017[<xref ref-type="bibr" rid="R17">17</xref>]; Rigalli et al., 2019[<xref ref-type="bibr" rid="R18">18</xref>]; Rohrdanz et al., 2002[<xref ref-type="bibr" rid="R19">19</xref>]; Sivo&#x148;ov&#xE1; et al., 2019[<xref ref-type="bibr" rid="R20">20</xref>]; Uifalean et al., 2018[<xref ref-type="bibr" rid="R21">21</xref>]; Wei et al., 2019[<xref ref-type="bibr" rid="R22">22</xref>]; Zheng et al., 2017[<xref ref-type="bibr" rid="R25">25</xref>]; Zheng et al., 2018[<xref ref-type="bibr" rid="R24">24</xref>]; Zhu et al., 2018[<xref ref-type="bibr" rid="R26">26</xref>]). </p></sec>
    <sec>
      <title>Conflict of interest</title><p>The authors declare no conflict of interest.</p></sec>
  </body>
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  <floats-wrap>
    <fig id="T1" position="float">
      <label>Table 1</label>
      <caption><title>Recent updates on daidzein against oxidative stress and cancer</title></caption>
      <graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="EXCLI-18-950-t-001" />
    </fig>
  </floats-wrap>
</article>