Letter to the editor

Current update on the protective effect of naringin in inflammatory lung diseases

Gaurav Gupta¹[*]^,2, Waleed Hassan Almalki³, Imran Kazmi⁴, Neeraj Kumar Fuloria⁵, Shivkanya Fuloria⁵, Vetriselvan Subramaniyan⁶, Mahendran Sekar⁷, Sachin Kumar Singh^8,9, Dinesh Kumar Chellappan¹⁰, Kamal Dua^9,11

¹School of Pharmacy, Suresh Gyan Vihar University, Jagatpura 302017, Mahal Road, Jaipur, India

²Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India

³Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia

⁴Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia

⁵Faculty of Pharmacy, AIMST University, Bedong 08100, Kedah, Malaysia

⁶Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jalan SP 2, Bandar Saujana Putra, 42610 Jenjarom Selangor, Malaysia

⁷Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh 30450, Perak, Malaysia

⁸School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India

⁹Faculty of Health, Australian Research Center in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, Australia

¹⁰Department of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur, 57000, Malaysia

¹¹Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Australia

EXCLI J 2022;21:Doc573



Understanding the role of inflammation in developing respiratory illnesses such as COPD, asthma, and lung cancer, is critical. Natural cures are regaining favor as effective treatments for various ailments (Heidary Moghaddam et al., 2020[14]). A flavanone glycoside named naringin (NAR) is found in aromatic Chinese herbal treatments and citrus fruits. Even though several biological and pharmacological properties of NAR have been found via study, only a few systematic reviews have been published (Wadhwa et al., 2021[29]). However, there is a scarcity of studies focusing on NAR's therapeutic potential in respiratory system inflammation. NAR's alleged anti-inflammatory properties influence many pro-inflammatory cytokines, including the NF-κB, ERK1/2, and p38 MAPK pathways in the pathophysiological processes associated with chronic respiratory disorders (Chen et al., 2016[8]). This review will be very useful to researchers in this field. It will take them in a new direction in their hunt for innovative medications to treat respiratory illnesses (Table 1(Tab. 1); References in Table 1: Ahmad et al., 2015[1]; Akintunde et al., 2020[2]; Ali et al., 2017[3]; Bear and Teel, 2000[4]; Cerkezkayabekir et al., 2017[5]; Chang et al., 2017[6]; Chen et al., 2013[9], 2014[10], 2018[7]; Clementi et al., 2021[11]; Fouad et al., 2016[12]; Guihua et al., 2016[13]; Hsiao et al., 2007[15]; Jiao et al., 2015[16]; Kim et al., 2018[17]; Liu et al., 2011[20], 2012[19], 2018[18]; Luo et al., 2012[21]; Nie et al., 2012[22]; Schwarz et al., 2005[23]; Seyedrezazadeh et al., 2015[24]; Shi et al., 2014[27], 2019[25], 2021[26]; Turgut et al., 2016[28]; Wang et al., 2016[30]; Wu et al., 2021[31]; Yao et al., 2021[32]; Zhang et al., 2013[33]).

Conflict of interest

The authors declare no conflict of interest.

References