Letter to the editor

Current update on the protective effect of naringin in inflammatory lung diseases

Gaurav Gupta1[*],2, Waleed Hassan Almalki3, Imran Kazmi4, Neeraj Kumar Fuloria5, Shivkanya Fuloria5, Vetriselvan Subramaniyan6, Mahendran Sekar7, Sachin Kumar Singh8,9, Dinesh Kumar Chellappan10, Kamal Dua9,11

1School of Pharmacy, Suresh Gyan Vihar University, Jagatpura 302017, Mahal Road, Jaipur, India

2Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India

3Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia

4Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia

5Faculty of Pharmacy, AIMST University, Bedong 08100, Kedah, Malaysia

6Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jalan SP 2, Bandar Saujana Putra, 42610 Jenjarom Selangor, Malaysia

7Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh 30450, Perak, Malaysia

8School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India

9Faculty of Health, Australian Research Center in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, Australia

10Department of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur, 57000, Malaysia

11Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Australia

EXCLI J 2022;21:Doc573


Understanding the role of inflammation in developing respiratory illnesses such as COPD, asthma, and lung cancer, is critical. Natural cures are regaining favor as effective treatments for various ailments (Heidary Moghaddam et al., 2020[14]). A flavanone glycoside named naringin (NAR) is found in aromatic Chinese herbal treatments and citrus fruits. Even though several biological and pharmacological properties of NAR have been found via study, only a few systematic reviews have been published (Wadhwa et al., 2021[29]). However, there is a scarcity of studies focusing on NAR's therapeutic potential in respiratory system inflammation. NAR's alleged anti-inflammatory properties influence many pro-inflammatory cytokines, including the NF-κB, ERK1/2, and p38 MAPK pathways in the pathophysiological processes associated with chronic respiratory disorders (Chen et al., 2016[8]). This review will be very useful to researchers in this field. It will take them in a new direction in their hunt for innovative medications to treat respiratory illnesses (Table 1(Tab. 1); References in Table 1: Ahmad et al., 2015[1]; Akintunde et al., 2020[2]; Ali et al., 2017[3]; Bear and Teel, 2000[4]; Cerkezkayabekir et al., 2017[5]; Chang et al., 2017[6]; Chen et al., 2013[9], 2014[10], 2018[7]; Clementi et al., 2021[11]; Fouad et al., 2016[12]; Guihua et al., 2016[13]; Hsiao et al., 2007[15]; Jiao et al., 2015[16]; Kim et al., 2018[17]; Liu et al., 2011[20], 2012[19], 2018[18]; Luo et al., 2012[21]; Nie et al., 2012[22]; Schwarz et al., 2005[23]; Seyedrezazadeh et al., 2015[24]; Shi et al., 2014[27], 2019[25], 2021[26]; Turgut et al., 2016[28]; Wang et al., 2016[30]; Wu et al., 2021[31]; Yao et al., 2021[32]; Zhang et al., 2013[33]).

Conflict of interest

The authors declare no conflict of interest.



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30. Wang Y, Lu Y, Luo M, Shi X, Pan Y, Zeng H, et al. Evaluation of pharmacological relaxation effect of the natural product naringin on in vitro cultured airway smooth muscle cells and in vivo ovalbumin-induced asthma Balb/c mice. Biomed Rep. 2016;5:715-22. doi: 10.3892/br.2016.797
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33. Zhang Y, Wang JF, Dong J, Wei JY, Wang YN, Dai XH, et al. Inhibition of α-toxin production by subinhibitory concentrations of naringenin controls Staphylococcus aureus pneumonia. Fitoterapia. 2013;86:92-9. doi: 10.1016/j.fitote.2013.02.001

Table 1: An update on the protective effect of naringin in various inflammatory lung diseases

[*] Corresponding Author:

Gaurav Gupta, School of Pharmacy, Suresh Gyan Vihar University, Jagatpura 302017, Mahal Road, Jaipur, India, eMail: gauravpharma25@gmail.com