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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">EXCLI J</journal-id>
      <journal-title>EXCLI Journal</journal-title>
      <issn pub-type="epub">1611-2156</issn>
      <publisher>
        <publisher-name>Leibniz Research Centre for Working Environment and Human Factors</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">2024-8085</article-id>
      <article-id pub-id-type="doi">10.17179/excli2024-8085</article-id>
      <article-id pub-id-type="pii">Doc204</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Review article</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Reasons for using electronic cigarettes among young adults aged 18 &#x2013; 30: a systematic review</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Kinouani</surname>
            <given-names>Sh&#xE9;razade</given-names>
          </name>
          <xref ref-type="corresp" rid="COR1">&#x0002a;</xref>
          <xref ref-type="aff" rid="A1">1</xref>
          <xref ref-type="aff" rid="A2">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Roux</surname>
            <given-names>Faustine</given-names>
          </name>
          <xref ref-type="aff" rid="A2">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Questel</surname>
            <given-names>Bastien</given-names>
          </name>
          <xref ref-type="aff" rid="A2">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Abraham</surname>
            <given-names>Ma&#xEB;lys</given-names>
          </name>
          <xref ref-type="aff" rid="A3">3</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Tzourio</surname>
            <given-names>Christophe</given-names>
          </name>
          <xref ref-type="aff" rid="A1">1</xref>
        </contrib>
      </contrib-group>
      <aff id="A1">
        <label>1</label>University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team HEALTHY, UMR 1219, Bordeaux, France</aff>
      <aff id="A2">
        <label>2</label>Department of General Practice, University of Bordeaux, Bordeaux, France</aff>
      <aff id="A3">
        <label>3</label>48 avenue de Labarde, Bordeaux, France</aff>
      <author-notes>
        <corresp id="COR1">*To whom correspondence should be addressed: Shérazade Kinouani, Centre INSERM U1219 BPH, Equipe HEALTHY, Université de Bordeaux, 146 rue Léo Saignat, CS61292, 33076 Bordeaux Cedex France; Tel: + 33 (0)6 10 29 68 47, E-mail: <email>sherazade.kinouani@u-bordeaux.fr</email></corresp>
      </author-notes>
      <pub-date pub-type="epub">
        <day>31</day>
        <month>01</month>
        <year>2025</year>
      </pub-date>
      <pub-date pub-type="collection">
        <year>2025</year>
      </pub-date>
      <volume>24</volume>
      <fpage>204</fpage>
      <lpage>237</lpage>
      <history>
        <date date-type="received">
          <day>07</day>
          <month>12</month>
          <year>2024</year>
        </date>
        <date date-type="accepted">
          <day>27</day>
          <month>01</month>
          <year>2025</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>Copyright &#xA9; 2025 Kinouani et al.</copyright-statement>
        <copyright-year>2025</copyright-year>
        <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/">
          <p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/) You are free to copy, distribute and transmit the work, provided the original author and source are credited.</p>
        </license>
      </permissions>
      <self-uri xlink:href="https://www.excli.de/vol24/excli2024-8085.pdf">This article is available from https://www.excli.de/vol24/excli2024-8085.pdf</self-uri>
      <abstract><p>The use of psychoactive products by young adults is usually described as part of their exploratory identity development. This behavior is facilitated by social and structural contexts where these substances are perceived as legal and easily accessible. While the motivations for initiating and continuing the use of tobacco and alcohol are well-documented, the same cannot be said for e-cigarettes. The primary objective of this systematic review was to describe the reasons for initiation and continuation of e-cigarette use among adults aged 18 to 30. A secondary objective was to categorize these reasons into intrinsic (i.e., personal motivations) and extrinsic factors (i.e., sociocultural or structural influences). Searches were conducted in MEDLINE, Scopus, SocINDEX full text, PsycArticles, PsycInfo, Psychology and Behavioral Sciences Collection, Cochrane Library and gray literature. Studies involving humans, published in English or French up to June 2024 were eligible for inclusion. After removing 594 duplicates, 1,123 articles were screened by title and abstract, with 37 articles published between 2015 and 2024 ultimately included in the review. These comprised 21 cross-sectional studies, eight qualitative studies, six cross-sectional analyses of cohort data, one cohort study and one mixed methods study. The appeal of e-liquid flavors emerged as one of the most frequently reported extrinsic factors driving both initiation and continuation of e-cigarette use. Other reasons varied across intrinsic and extrinsic domains: smoking cessation was a commonly cited intrinsic motivation, often reported alongside other factors. Structural extrinsic factors such as regulatory policies appeared to be less recognized by young adults, suggesting a gap in awareness or compliance to such regulations. These findings indicate the need for further research to better understand young adults&#x27; perceptions of and interactions with regulatory measures concerning e-cigarette and tobacco use.</p></abstract>
      <kwd-group>
        <kwd>young adults</kwd>
        <kwd>electronic nicotine delivery systems</kwd>
        <kwd>vaping</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec>
      <title>Abbreviations</title><p>95 &#x25; CI: 95 &#x25; Confidence interval</p><p>COREQ: COnsolidated criteria for REporting Qualitative research</p><p>HIV: Human Immunodeficiency Virus</p><p>MMAT: Mixed Methods Appraisal Tool</p><p>MMARS: Mixed Methods Article Reporting Standards</p><p>OECD: Organisation for Economic Co-operation and Development</p><p>PAP: Psychoactive Products</p><p>STROBE: Strengthening the Reporting of Observational Studies in Epidemiology</p><p>UK: United Kingdom</p></sec>
    <sec sec-type="intro">
      <title>Introduction</title><p>The relationship between young adults aged 18-30 and psychoactive products (PAP) has been studied extensively by psychologists and sociologists. Jeffrey Jensen Arnett theorized that risk-taking behavior during emerging adulthood is a fundamental component of identity exploration. The PAP consumption reflects young adults&#x27; desire to accumulate diverse experiences before transitioning into the roles and responsibilities of adulthood (Arnett, 2000[<xref ref-type="bibr" rid="R3">3</xref>], 2005[<xref ref-type="bibr" rid="R6">6</xref>]; Arnett et al., 2014[<xref ref-type="bibr" rid="R7">7</xref>]). The friendships formed or deepened during this period exert limited influence in terms of social control, further enabling such behavior. Having friends who smoke tobacco has been identified as a significant predictor of tobacco initiation (Steinmetz-Wood et al., 2018[<xref ref-type="bibr" rid="R75">75</xref>]). The first time trying an e-cigarette is almost always done in the presence of friends or a family member who already uses one (McKeganey et al., 2018[<xref ref-type="bibr" rid="R54">54</xref>]); having friends or living with someone who vapes is associated with the risk of later initiation of e-cigarette use (Urman et al., 2019[<xref ref-type="bibr" rid="R82">82</xref>]). Another explanation for the relationship between young adults and PAP is found in the Sociology of deviance (Becker, 1963[<xref ref-type="bibr" rid="R10">10</xref>]; Peretti-Watel et al., 2007[<xref ref-type="bibr" rid="R65">65</xref>][<xref ref-type="bibr" rid="R64">64</xref>][<xref ref-type="bibr" rid="R66">66</xref>]). Behavior is classified as deviant when it causes social problems for the social group that sets the norms in a given time and space. In his research, Howard Becker examined the experiences of American cannabis smokers and described their &#x22;moral career&#x22; as a diachronic trajectory of cannabis use that is constructed in both objective and subjective ways (Becker, 1963[<xref ref-type="bibr" rid="R10">10</xref>]). From an objective point of view, a user&#x27;s career consists of successive stages: experimentation, occasional use, and then regular use. Going beyond simple experimentation requires repeated and progressive learning about the use and effects of the product. As Peretti-Watel explained, &#x22;<italic>experimentation would be motivated primarily by curiosity, with the desired effects becoming a motivation only when the individual has learned to perceive them and develop a taste for them</italic>&#x201D; (Peretti-Watel et al., 2007[<xref ref-type="bibr" rid="R65">65</xref>]). Experimentation requires both that the product be accessible and socially acceptable (extrinsic factors) and that the subject be willing to try it (intrinsic factors). Regular or occasional use in addition requires that the subject be inclined to learn how to use it (intrinsic factors). Finally, from a subjective point of view, consumers neutralize social stereotypes and re-adjust their own opinions at each stage of the objective moral career in order to continue to see themselves as non-deviant. The Sociology of deviance emphasizes the importance of distinguishing between the reasons for experimenting with a PAP and the reasons for continuing to use it. To our knowledge, this theory has been little explored in the context of e-cigarette use.</p><p>A projection based on data from the National Health Interview Survey indicates that the prevalence of smoking in the United States has declined at an accelerated rate over the past decade, in line with the observed increase in the use of e-cigarettes, also known as vaping. The prevalence of smoking observed following the introduction of e-cigarettes in the United States in 2007 was lower than expected based on trends between 1990 and 2006, particularly among individuals aged 18-34 (Foxon et al., 2024[<xref ref-type="bibr" rid="R24">24</xref>]). Regarding e-cigarette use among young adults, the prevalence of current e-cigarette use (defined as occasional or daily use at the time of the survey) among Americans aged 18-24 in 2021 was estimated to be 11 &#x25; (Cornelius et al., 2023[<xref ref-type="bibr" rid="R21">21</xref>]; Kramarow and Elgaddal, 2023[<xref ref-type="bibr" rid="R48">48</xref>]). Exclusive use of e-cigarettes was more common than exclusive use of tobacco cigarettes or concurrent use of tobacco cigarettes and e-cigarettes (dual use). In 2017, the prevalence of regular e-cigarette use (defined as weekly or daily use) was estimated at 1.8 &#x25; in a representative sample of Europeans aged 15 and older. This represents an increase in use of 21.2 &#x25; between 2014 and 2017 (Laverty et al., 2018[<xref ref-type="bibr" rid="R49">49</xref>]). Compared with those aged 55 or older, those aged 15-24 were more likely to have tried e-cigarettes in 2017, but less likely to be regular users (Laverty et al., 2018[<xref ref-type="bibr" rid="R49">49</xref>]). In 2019, the prevalence of current use (defined as occasional or daily use at the time of the survey) was 5.1 &#x25; among Europeans aged 15-24 (OECD&#x2F;European Union, 2022[<xref ref-type="bibr" rid="R59">59</xref>]). </p><p>The factors driving young adults to use e-cigarettes (also referred to as electronic cigarettes, electronic nicotine delivery systems, or vaping devices) appear to be less well-documented compared to those associated with tobacco or alcohol use. However, similar to tobacco and alcohol, the sale and use of e-cigarettes by young adults is permitted in most developed countries. This permissive structural context may have contributed to their growing interest in vaping products. </p><p>To better understand such behavior, we conducted a literature review to identify and distinguish between the reasons for initiating e-cigarette use and those for its continued use, conceptualizing these as two discrete stages in the trajectory of e-cigarette consumption. We hypothesized that intrinsic factors (i.e., personal motivations) and extrinsic factors (i.e., sociocultural or structural influences) would complement each other in shaping vapers&#x27; trajectories. </p><p>Thus, the primary objective of this systematic review was to describe the reasons for initiating and maintaining e-cigarette use among individuals aged 18-30. The secondary aim was to categorize these reasons into intrinsic and extrinsic factors to provide a comprehensive framework for understanding the dynamics of vaping behaviors within this age group.</p></sec>
    <sec sec-type="materials|methods">
      <title>Materials and Methods</title><p>This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines (Page et al., 2021[<xref ref-type="bibr" rid="R62">62</xref>]). The protocol details were registered in Prospero (number CRD42024553490).</p><sec><title>Data sources and search strategy</title><p>We searched the following electronic databases for articles published in English or French up to June 2, 2024: MEDLINE, Scopus, SocINDEX with full text, PsycArticles, PsycInfo, Psychology and Behavioral Sciences Collection, Cochrane Library. For gray literature, we used an international search engine BASE (<ext-link ext-link-type="uri" xlink:href="https:&#47;&#47;www.base-search.net&#47;">https:&#47;&#47;www.base-search.net&#47;</ext-link>). The list of search equations is shown in Table 1<xref ref-type="fig" rid="T1">(Tab. 1)</xref>. Two hundred and six additional records were identified through analysis of the references of the included articles and through consultation with members of the research team.</p></sec><sec><title>Article screening</title><sec><title>Population eligibility criteria</title><p>We focused this review on adults between the ages of 18 and 30. Participants had to have used e-cigarettes at least once. If multiple age groups were described in the articles, only reasons for using e-cigarettes related to adults aged 18 to 30 were selected. Articles focusing on specific comorbidity populations (such as those with HIV, mental illness, chronic disease, etc.) or lacking sufficient information to estimate the age of participants were excluded. Articles with insufficient information to estimate the number of young adult users to be considered were also excluded.</p></sec><sec><title>Article eligibility criteria</title><p>All study designs were included. We defined reasons for use as reasons reported by e-cigarette users: i) to initiate or try e-cigarettes for the first time (reasons for initiation); ii) to continue using after initiation, regardless of frequency or duration of use (reasons for continuation). Articles that reported only intentions to use among non-users were excluded from the analysis. Articles that solely addressed awareness, representations or perceptions of e-cigarette use without exploring reasons for use were excluded from the review. Articles were also excluded if it was not clear whether the reasons explored were related to initiation or continuation of e-cigarette use. </p></sec><sec><title>Article selection</title><p>First, two trained students (FR and BQ) selected articles and independently evaluated them on title and abstract. They tried to resolve their disagreements by consensus. A third reviewer (SK) read the 11 articles where students disagreed. She included 10 and excluded one. Then FR and BQ read the full text of the selected articles independently. Their reviewers&#x27; agreement was assessed using Cohen&#x27;s unweighted kappa coefficient, which was estimated to be 0.488 (95 &#x25; CI: 0.330-0.645). This indicated moderate agreement. They were able to reach full agreement after discussing their differences without the need for a third reviewer. These two steps were performed using Rayyan software (Ouzzani et al., 2016[<xref ref-type="bibr" rid="R60">60</xref>]).</p></sec></sec><sec><title>Data extraction, synthesis and quality assessment</title><p>Each student extracted information from half of the documents selected in the previous phase. Each extraction was fully verified by SK. The following information was extracted: location, study design, data collection strategy, participant characteristics, definitions and reasons for using e-cigarettes.</p><p>Each student was responsible for assessing the quality of half of the studies. SK conducted a similar assessment independently for all articles. They all used the Mixed Methods Appraisal Tool or MMAT (Pace et al., 2012[<xref ref-type="bibr" rid="R61">61</xref>]; Souto et al., 2015[<xref ref-type="bibr" rid="R74">74</xref>]; Hong et al., 2018[<xref ref-type="bibr" rid="R36">36</xref>], 2019[<xref ref-type="bibr" rid="R37">37</xref>]). SK compared her MMAT score with that of the student&#x27;s to reach a consensus for each study. The MMAT score was decided as follows: 0-2: poor quality; 3-4: fair quality; 5: good quality. SK also assessed the quality of reporting in all articles using the appropriate assessment tools: STROBE for cross-sectional or cohort studies (von Elm et al., 2007[<xref ref-type="bibr" rid="R84">84</xref>]), COREQ for qualitative studies (Tong et al., 2007[<xref ref-type="bibr" rid="R80">80</xref>]), MMARS for mixed methods studies (Levitt et al., 2018[<xref ref-type="bibr" rid="R51">51</xref>]). The quality of reporting was classified as poor, fair, or good. Finally, SK assessed a combination of the quality of reporting in the article and the quality of the study, according to the rules presented in Supplementary information (Table S1).</p><p>SK conducted the synthesis on reasons for e-cigarette use, first dividing them into reasons for initiation and reasons for continued use. She then distinguished intrinsic reasons from extrinsic reasons. During her analysis, it appeared that reasons related to vaping product features were a separate category of extrinsic factors. She decided to individualize them.</p><p>All studies that were retained at the conclusion of the full-text reading selection were included in the main analysis, irrespective of their global quality assessment. A robustness analysis was conducted by removing studies of low quality or with declared conflicts of interest.</p></sec></sec>
    <sec sec-type="results">
      <title>Results</title><sec><title>Description of studies</title><p>After removing duplicates, 1123 documents were identified. Screening based on title and abstract allowed 117 documents to be retained. After reading the full text, 37 were finally retained for the systematic review, describing 37 different studies. The flow diagram is shown in Figure 1<xref ref-type="fig" rid="F1">(Fig. 1)</xref>. These included 35 English-language articles, one English-language study report (Meng and Ponce, 2020[<xref ref-type="bibr" rid="R55">55</xref>]), and one French-language study report (Chok et al., 2023[<xref ref-type="bibr" rid="R19">19</xref>]) (see Table 2<xref ref-type="fig" rid="T2">(Tab. 2)</xref> for all studies used; References In Table 2: Awan, 2016[<xref ref-type="bibr" rid="R8">8</xref>]; Bunch et al., 2018[<xref ref-type="bibr" rid="R14">14</xref>]; Buu et al., 2020[<xref ref-type="bibr" rid="R15">15</xref>]; Case et al., 2020[<xref ref-type="bibr" rid="R16">16</xref>]; Cheney et al., 2016[<xref ref-type="bibr" rid="R17">17</xref>]; Chok et al., 2023[<xref ref-type="bibr" rid="R19">19</xref>]; Cooper et al., 2016[<xref ref-type="bibr" rid="R20">20</xref>]; Davis et al., 2024[<xref ref-type="bibr" rid="R22">22</xref>]; Dunlop et al., 2016[<xref ref-type="bibr" rid="R23">23</xref>]; Freeman et al., 2023[<xref ref-type="bibr" rid="R25">25</xref>]; Hoek et al., 2017[<xref ref-type="bibr" rid="R34">34</xref>]; Hong et al., 2019[<xref ref-type="bibr" rid="R35">35</xref>]; Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]; Jongenelis et al., 2019[<xref ref-type="bibr" rid="R40">40</xref>]; Kava et al., 2021[<xref ref-type="bibr" rid="R41">41</xref>]; Kechter et al., 2022[<xref ref-type="bibr" rid="R42">42</xref>]; Khouja et al., 2020[<xref ref-type="bibr" rid="R43">43</xref>]; Kinouani et al., 2017[<xref ref-type="bibr" rid="R46">46</xref>], 2024[<xref ref-type="bibr" rid="R45">45</xref>]; Lotrean, 2015[<xref ref-type="bibr" rid="R52">52</xref>]; Martinasek et al., 2018[<xref ref-type="bibr" rid="R53">53</xref>]; Meng and Ponce, 2020[<xref ref-type="bibr" rid="R55">55</xref>]; Newcombe et al., 2021[<xref ref-type="bibr" rid="R56">56</xref>]; Obisesan et al., 2023[<xref ref-type="bibr" rid="R58">58</xref>]; Patel et al., 2016[<xref ref-type="bibr" rid="R63">63</xref>]; Pettigrew et al., 2023[<xref ref-type="bibr" rid="R67">67</xref>][<xref ref-type="bibr" rid="R68">68</xref>]; Pinho-Gomes et al., 2023[<xref ref-type="bibr" rid="R69">69</xref>]; Robertson et al., 2022[<xref ref-type="bibr" rid="R70">70</xref>]; Roh et al., 2024[<xref ref-type="bibr" rid="R71">71</xref>]; Rostron et al., 2020[<xref ref-type="bibr" rid="R72">72</xref>]; Stone et al., 2023[<xref ref-type="bibr" rid="R76">76</xref>]; Tamulevicius et al., 2020[<xref ref-type="bibr" rid="R78">78</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]; Tran et al., 2024[<xref ref-type="bibr" rid="R81">81</xref>]; Vu et al., 2018[<xref ref-type="bibr" rid="R85">85</xref>], 2019[<xref ref-type="bibr" rid="R86">86</xref>]). As shown in Table 2<xref ref-type="fig" rid="T2">(Tab. 2)</xref>, the articles were published between 2015 and the first five months of 2024: one in 2015, five in 2016, two in 2017, three in 2018, three in 2019, seven in 2020, two in 2021, two in 2022, seven in 2023, and five in 2024. Twenty-one studies were conducted in the United States, five in Australia, two in New Zealand, two in the United Kingdom (UK), two in France, one in China, one in Switzerland, one in Romania, one in Spain, and one in Saudi Arabia. One study was conducted simultaneously in three countries: United States, Germany, and South Africa. Studies included 21 cross-sectional studies, 6 cross-sectional analyses of cohort data, one cohort with 12 months of follow-up, 8 qualitative studies using thematic analysis, and one study using mixed methods (Table 2<xref ref-type="fig" rid="T2">(Tab. 2)</xref>). Some studies were conducted in specific subgroups based on student status, smoking status, or type of electronic device used (Tables 3<xref ref-type="fig" rid="T3">(Tab. 3)</xref> and 4<xref ref-type="fig" rid="T4">(Tab. 4)</xref>). There were 14 studies carried out among college students, one among young adults who had not completed higher education (Cheney et al., 2016[<xref ref-type="bibr" rid="R17">17</xref>]), one exclusively among young adults who had never smoked tobacco before vaping (Tran et al., 2024[<xref ref-type="bibr" rid="R81">81</xref>]), one among subjects who had never &#x22;smoked cigarettes regularly&#x22; (Robertson et al., 2022[<xref ref-type="bibr" rid="R70">70</xref>]), one among former or current tobacco smokers (Dunlop et al., 2016[<xref ref-type="bibr" rid="R23">23</xref>]). There were also five studies among pod users (Case et al., 2020[<xref ref-type="bibr" rid="R16">16</xref>]; Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]; Kava et al., 2021[<xref ref-type="bibr" rid="R41">41</xref>]; Newcombe et al., 2021[<xref ref-type="bibr" rid="R56">56</xref>]; Obisesan et al., 2023[<xref ref-type="bibr" rid="R58">58</xref>]), one study among users of disposable e-cigarettes called puffs (Chok et al., 2023[<xref ref-type="bibr" rid="R19">19</xref>]), and one study focused on the use of synthetic nicotine (tobacco-free e-cigarettes) (Davis et al., 2024[<xref ref-type="bibr" rid="R22">22</xref>]).</p><p>As shown in Supplementary information (Table S2), e-cigarette use was defined in different ways, whether as initiation or continuation. Studies often referred to the first try or experience (even if it was only 1 or 2 puffs) as initiated use. Continued use ranged from current use at the time of the survey (regardless of frequency) to use over at least 6 months (with the participant bringing their most recent device to the interview). The definition used in the quantitative studies was not always clear: three studies concerned current use without ever defining it or giving more details (Dunlop et al., 2016[<xref ref-type="bibr" rid="R23">23</xref>]; Bunch et al., 2018[<xref ref-type="bibr" rid="R14">14</xref>]; Khouja et al., 2020[<xref ref-type="bibr" rid="R43">43</xref>]). However, most studies referred to use in the past 30 days or in the past month.</p></sec><sec><title>Reasons for initiating use</title><p>Eighteen studies reported reasons for initiation of cigarette use among young adults (Table 3<xref ref-type="fig" rid="T3">(Tab. 3)</xref>; References in Table 3: Awan, 2016[<xref ref-type="bibr" rid="R8">8</xref>]; Cheney et al., 2016[<xref ref-type="bibr" rid="R17">17</xref>]; Davis et al., 2024[<xref ref-type="bibr" rid="R22">22</xref>]; Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]; Kava et al., 2021[<xref ref-type="bibr" rid="R41">41</xref>]; Kechter et al., 2022[<xref ref-type="bibr" rid="R42">42</xref>]; Kinouani et al., 2017[<xref ref-type="bibr" rid="R46">46</xref>], 2024[<xref ref-type="bibr" rid="R45">45</xref>]; Lotrean, 2015[<xref ref-type="bibr" rid="R52">52</xref>]; Martinasek et al., 2018[<xref ref-type="bibr" rid="R53">53</xref>]; Obisesan et al., 2023[<xref ref-type="bibr" rid="R58">58</xref>]; Robertson et al., 2022[<xref ref-type="bibr" rid="R70">70</xref>]; Roh et al., 2024[<xref ref-type="bibr" rid="R71">71</xref>]; Tamulevicius et al., 2020[<xref ref-type="bibr" rid="R78">78</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]; Tran et al., 2024[<xref ref-type="bibr" rid="R81">81</xref>]; Vu et al., 2018[<xref ref-type="bibr" rid="R85">85</xref>], 2019[<xref ref-type="bibr" rid="R86">86</xref>]). According to the 11 quantitative studies and the quantitative phase of the mixed methods study, reasons for initiating e-cigarette use included: out of curiosity (Lotrean, 2015[<xref ref-type="bibr" rid="R52">52</xref>]; Awan, 2016[<xref ref-type="bibr" rid="R8">8</xref>]; Kinouani et al., 2017[<xref ref-type="bibr" rid="R46">46</xref>], 2024[<xref ref-type="bibr" rid="R45">45</xref>]; Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]; Obisesan et al., 2023[<xref ref-type="bibr" rid="R58">58</xref>]; Davis et al., 2024[<xref ref-type="bibr" rid="R22">22</xref>]; Roh et al., 2024[<xref ref-type="bibr" rid="R71">71</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]) or the desire to try new things (Vu et al., 2019[<xref ref-type="bibr" rid="R86">86</xref>]; Tamulevicius et al., 2020[<xref ref-type="bibr" rid="R78">78</xref>]); appeal of flavors (Kinouani et al., 2017[<xref ref-type="bibr" rid="R46">46</xref>], 2024[<xref ref-type="bibr" rid="R45">45</xref>]; Martinasek et al., 2018[<xref ref-type="bibr" rid="R53">53</xref>]; Vu et al., 2019[<xref ref-type="bibr" rid="R86">86</xref>]; Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]; Tamulevicius et al., 2020[<xref ref-type="bibr" rid="R78">78</xref>]; Obisesan et al., 2023[<xref ref-type="bibr" rid="R58">58</xref>]; Davis et al., 2024[<xref ref-type="bibr" rid="R22">22</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]) in terms of variety, accessibility, and availability; perception of vaping as less harmful to health than smoking (Lotrean, 2015[<xref ref-type="bibr" rid="R52">52</xref>]; Awan, 2016[<xref ref-type="bibr" rid="R8">8</xref>]; Kinouani et al., 2017[<xref ref-type="bibr" rid="R46">46</xref>], 2024[<xref ref-type="bibr" rid="R45">45</xref>]; Vu et al., 2019[<xref ref-type="bibr" rid="R86">86</xref>]; Obisesan et al., 2023[<xref ref-type="bibr" rid="R58">58</xref>]; Davis et al., 2024[<xref ref-type="bibr" rid="R22">22</xref>]; Roh et al., 2024[<xref ref-type="bibr" rid="R71">71</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]); quitting smoking (Lotrean, 2015[<xref ref-type="bibr" rid="R52">52</xref>]; Awan, 2016[<xref ref-type="bibr" rid="R8">8</xref>]; Kinouani et al., 2017[<xref ref-type="bibr" rid="R46">46</xref>], 2024[<xref ref-type="bibr" rid="R45">45</xref>]; Martinasek et al., 2018[<xref ref-type="bibr" rid="R53">53</xref>]; Vu et al., 2019[<xref ref-type="bibr" rid="R86">86</xref>]; Tamulevicius et al., 2020[<xref ref-type="bibr" rid="R78">78</xref>]; Davis et al., 2024[<xref ref-type="bibr" rid="R22">22</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]) or reducing smoking (Kinouani et al., 2017[<xref ref-type="bibr" rid="R46">46</xref>], 2024[<xref ref-type="bibr" rid="R45">45</xref>]; Obisesan et al., 2023[<xref ref-type="bibr" rid="R58">58</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]); using vaping to avoid the inconveniences of smoking such as bans on smoking in certain places (Kinouani et al., 2017[<xref ref-type="bibr" rid="R46">46</xref>], 2024[<xref ref-type="bibr" rid="R45">45</xref>]; Obisesan et al., 2023[<xref ref-type="bibr" rid="R58">58</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]), to avoid the bad smell of smoking (Vu et al., 2019[<xref ref-type="bibr" rid="R86">86</xref>]; Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]; Obisesan et al., 2023[<xref ref-type="bibr" rid="R58">58</xref>]; Davis et al., 2024[<xref ref-type="bibr" rid="R22">22</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]), or exposure to second-hand smoke (Obisesan et al., 2023[<xref ref-type="bibr" rid="R58">58</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]). Having people around you who used tobacco or e-cigarettes also facilitated initiation: having friends (Lotrean, 2015[<xref ref-type="bibr" rid="R52">52</xref>]; Awan, 2016[<xref ref-type="bibr" rid="R8">8</xref>]; Vu et al., 2019[<xref ref-type="bibr" rid="R86">86</xref>]; Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]; Tamulevicius et al., 2020[<xref ref-type="bibr" rid="R78">78</xref>]; Roh et al., 2024[<xref ref-type="bibr" rid="R71">71</xref>]) or family (Roh et al., 2024[<xref ref-type="bibr" rid="R71">71</xref>]) who had already vaped, having friends who suggested trying for the first time by sharing their e-cigarette (Kinouani et al., 2017[<xref ref-type="bibr" rid="R46">46</xref>], 2024[<xref ref-type="bibr" rid="R45">45</xref>]; Obisesan et al., 2023[<xref ref-type="bibr" rid="R58">58</xref>]). Perceiving vaping as cheaper than smoking (Kinouani et al., 2017[<xref ref-type="bibr" rid="R46">46</xref>], 2024[<xref ref-type="bibr" rid="R45">45</xref>]; Vu et al., 2019[<xref ref-type="bibr" rid="R86">86</xref>]; Davis et al., 2024[<xref ref-type="bibr" rid="R22">22</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]) or as a cool practice (Martinasek et al., 2018[<xref ref-type="bibr" rid="R53">53</xref>]; Tamulevicius et al., 2020[<xref ref-type="bibr" rid="R78">78</xref>]; Davis et al., 2024[<xref ref-type="bibr" rid="R22">22</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]) were other reported reasons for initiation, as was the fun aspect of vaping tricks (Vu et al., 2019[<xref ref-type="bibr" rid="R86">86</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]; Roh et al., 2024[<xref ref-type="bibr" rid="R71">71</xref>]). Less commonly reported reasons in quantitative studies included: trying vaping to manage stress or anxiety (Martinasek et al., 2018[<xref ref-type="bibr" rid="R53">53</xref>]; Davis et al., 2024[<xref ref-type="bibr" rid="R22">22</xref>]; Roh et al., 2024[<xref ref-type="bibr" rid="R71">71</xref>]); to manage tobacco cravings (Obisesan et al., 2023[<xref ref-type="bibr" rid="R58">58</xref>]; Davis et al., 2024[<xref ref-type="bibr" rid="R22">22</xref>]), to control weight or appetite (Martinasek et al., 2018[<xref ref-type="bibr" rid="R53">53</xref>]; Tamulevicius et al., 2020[<xref ref-type="bibr" rid="R78">78</xref>]), to get an energy boost (Davis et al., 2024[<xref ref-type="bibr" rid="R22">22</xref>]), to avoid smoking relapse (Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]), for ease of use (Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]), for availability of e-cigarettes (Davis et al., 2024[<xref ref-type="bibr" rid="R22">22</xref>]; Roh et al., 2024[<xref ref-type="bibr" rid="R71">71</xref>]), for discretion of use (Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]; Roh et al., 2024[<xref ref-type="bibr" rid="R71">71</xref>]), because of social acceptability (Davis et al., 2024[<xref ref-type="bibr" rid="R22">22</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]), perceiving vaping as similar to smoking (Obisesan et al., 2023[<xref ref-type="bibr" rid="R58">58</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]), perceiving it as a pleasant and enjoyable practice (Davis et al., 2024[<xref ref-type="bibr" rid="R22">22</xref>]), combining vaping with alcohol or cannabis use (Davis et al., 2024[<xref ref-type="bibr" rid="R22">22</xref>]), appeal of advertising (Obisesan et al., 2023[<xref ref-type="bibr" rid="R58">58</xref>]), seeing a celebrity (on TV or online) who vape (Roh et al., 2024[<xref ref-type="bibr" rid="R71">71</xref>]) or recommendation of use by a healthcare professional  (Vu et al., 2019[<xref ref-type="bibr" rid="R86">86</xref>]). Some of these studies suggested that curiosity was the main reason for experimenting with e-cigarettes, regardless of smoking status (Lotrean, 2015[<xref ref-type="bibr" rid="R52">52</xref>]; Awan, 2016[<xref ref-type="bibr" rid="R8">8</xref>]; Kinouani et al., 2017[<xref ref-type="bibr" rid="R46">46</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]).</p><p>According to the six qualitative studies and the mixed methods study, flavors had an attractive potential (Cheney et al., 2016[<xref ref-type="bibr" rid="R17">17</xref>]; Vu et al., 2018[<xref ref-type="bibr" rid="R85">85</xref>]), especially because of their variety (Kechter et al., 2022[<xref ref-type="bibr" rid="R42">42</xref>]). They reported that e-cigarettes were perceived as a less harmful alternative to smoking (Vu et al., 2018[<xref ref-type="bibr" rid="R85">85</xref>]; Kechter et al., 2022[<xref ref-type="bibr" rid="R42">42</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]). Perceived social acceptability (Kechter et al., 2022[<xref ref-type="bibr" rid="R42">42</xref>]) was also a factor promoting initiation. A family member may have encouraged the initiation of vaping either following their own vaping experience (Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]), or by insisting that smokers quit tobacco (Cheney et al., 2016[<xref ref-type="bibr" rid="R17">17</xref>]). Experimentation may also have been encouraged by peers (Kechter et al., 2022[<xref ref-type="bibr" rid="R42">42</xref>]). The first try often took place with vaping friends (Cheney et al., 2016[<xref ref-type="bibr" rid="R17">17</xref>]; Vu et al., 2018[<xref ref-type="bibr" rid="R85">85</xref>]) who shared their electronic devices for the occasion (Cheney et al., 2016[<xref ref-type="bibr" rid="R17">17</xref>]; Kava et al., 2021[<xref ref-type="bibr" rid="R41">41</xref>]; Robertson et al., 2022[<xref ref-type="bibr" rid="R70">70</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]). Curiosity led to trying an e-cigarette when in contact with these vaping friends (Kechter et al., 2022[<xref ref-type="bibr" rid="R42">42</xref>]; Tran et al., 2024[<xref ref-type="bibr" rid="R81">81</xref>]), as did the fun and playful aspect of this shared experience (Robertson et al., 2022[<xref ref-type="bibr" rid="R70">70</xref>]). E-cigarettes were described as facilitating social interactions (Kava et al., 2021[<xref ref-type="bibr" rid="R41">41</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]) and integration (Tran et al., 2024[<xref ref-type="bibr" rid="R81">81</xref>]) among peers. Some qualitative studies also described initiating e-cigarettes as a means to circumvent smoking bans in certain places (Vu et al., 2018[<xref ref-type="bibr" rid="R85">85</xref>]), to cope with stress (Tran et al., 2024[<xref ref-type="bibr" rid="R81">81</xref>]), boredom (Tran et al., 2024[<xref ref-type="bibr" rid="R81">81</xref>]), to suppress appetite (Tran et al., 2024[<xref ref-type="bibr" rid="R81">81</xref>]), to quit smoking (Vu et al., 2018[<xref ref-type="bibr" rid="R85">85</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]) or reduce smoking (Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]). E-cigarettes were described by some young adults as easier and more enjoyable to use than traditional nicotine replacement therapies (Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]).</p><p>The most common extrinsic factors for e-cigarette experimentation reported in the articles were the appeal of e-liquid flavors and the opportunity to try it with close vapers (family, friends, and peers). Curiosity, the perception that vaping is less harmful than smoking, and quitting smoking were the most reported intrinsic factors for experimentation (Supplementary information, Table S3).</p></sec><sec><title>Reasons for continuing use</title><p>Twenty-eight studies reported reasons for continued vaping among young adults (Table 4<xref ref-type="fig" rid="T4">(Tab. 4)</xref>; References in Table 4: Bunch et al., 2018[<xref ref-type="bibr" rid="R14">14</xref>]; Buu et al., 2020[<xref ref-type="bibr" rid="R15">15</xref>]; Case et al., 2020[<xref ref-type="bibr" rid="R16">16</xref>]; Cheney et al., 2016[<xref ref-type="bibr" rid="R17">17</xref>]; Chok et al., 2023[<xref ref-type="bibr" rid="R19">19</xref>]; Cooper et al., 2016[<xref ref-type="bibr" rid="R20">20</xref>]; Dunlop et al., 2016[<xref ref-type="bibr" rid="R23">23</xref>]; Freeman et al., 2023[<xref ref-type="bibr" rid="R25">25</xref>]; Hoek et al., 2017[<xref ref-type="bibr" rid="R34">34</xref>]; Hong et al., 2019[<xref ref-type="bibr" rid="R35">35</xref>]; Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]; Jongenelis et al., 2019[<xref ref-type="bibr" rid="R40">40</xref>]; Kava et al., 2021[<xref ref-type="bibr" rid="R41">41</xref>]; Kechter et al., 2022[<xref ref-type="bibr" rid="R42">42</xref>]; Khouja et al., 2020[<xref ref-type="bibr" rid="R43">43</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]; Meng and Ponce, 2020[<xref ref-type="bibr" rid="R55">55</xref>]; Newcombe et al., 2021[<xref ref-type="bibr" rid="R56">56</xref>]; Patel et al., 2016[<xref ref-type="bibr" rid="R63">63</xref>]; Pettigrew et al., 2023[<xref ref-type="bibr" rid="R67">67</xref>][<xref ref-type="bibr" rid="R68">68</xref>]; Pinho-Gomes et al., 2023[<xref ref-type="bibr" rid="R69">69</xref>]; Robertson et al., 2022[<xref ref-type="bibr" rid="R70">70</xref>]; Roh et al., 2024[<xref ref-type="bibr" rid="R71">71</xref>]; Rostron et al., 2020[<xref ref-type="bibr" rid="R72">72</xref>]; Stone et al., 2023[<xref ref-type="bibr" rid="R76">76</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]; Vu et al., 2018[<xref ref-type="bibr" rid="R85">85</xref>]). According to the 20 qualitative studies and the mixed methods study, the most common reasons for continued e-cigarette use in the studies were: quitting smoking (Dunlop et al., 2016[<xref ref-type="bibr" rid="R23">23</xref>]; Patel et al., 2016[<xref ref-type="bibr" rid="R63">63</xref>]; Bunch et al., 2018[<xref ref-type="bibr" rid="R14">14</xref>]; Hong et al., 2019[<xref ref-type="bibr" rid="R35">35</xref>]; Jongenelis et al., 2019[<xref ref-type="bibr" rid="R40">40</xref>]; Buu et al., 2020[<xref ref-type="bibr" rid="R15">15</xref>]; Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]; Khouja et al., 2020[<xref ref-type="bibr" rid="R43">43</xref>]; Meng and Ponce, 2020[<xref ref-type="bibr" rid="R55">55</xref>]; Chok et al., 2023[<xref ref-type="bibr" rid="R19">19</xref>]; Freeman et al., 2023[<xref ref-type="bibr" rid="R25">25</xref>]; Pettigrew et al., 2023[<xref ref-type="bibr" rid="R67">67</xref>][<xref ref-type="bibr" rid="R68">68</xref>]; Pinho-Gomes et al., 2023[<xref ref-type="bibr" rid="R69">69</xref>]; Stone et al., 2023[<xref ref-type="bibr" rid="R76">76</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]); appeal of flavors (Patel et al., 2016[<xref ref-type="bibr" rid="R63">63</xref>]; Hong et al., 2019[<xref ref-type="bibr" rid="R35">35</xref>]; Buu et al., 2020[<xref ref-type="bibr" rid="R15">15</xref>]; Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]; Rostron et al., 2020[<xref ref-type="bibr" rid="R72">72</xref>]; Newcombe et al., 2021[<xref ref-type="bibr" rid="R56">56</xref>]; Chok et al., 2023[<xref ref-type="bibr" rid="R19">19</xref>]; Pettigrew et al., 2023[<xref ref-type="bibr" rid="R67">67</xref>][<xref ref-type="bibr" rid="R68">68</xref>]; Pinho-Gomes et al., 2023[<xref ref-type="bibr" rid="R69">69</xref>]; Stone et al., 2023[<xref ref-type="bibr" rid="R76">76</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]; Roh et al., 2024[<xref ref-type="bibr" rid="R71">71</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]); less harm perceived for self or others in vaping compared to smoking (Dunlop et al., 2016[<xref ref-type="bibr" rid="R23">23</xref>]; Patel et al., 2016[<xref ref-type="bibr" rid="R63">63</xref>]; Hong et al., 2019[<xref ref-type="bibr" rid="R35">35</xref>]; Buu et al., 2020[<xref ref-type="bibr" rid="R15">15</xref>]; Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]; Chok et al., 2023[<xref ref-type="bibr" rid="R19">19</xref>]; Freeman et al., 2023[<xref ref-type="bibr" rid="R25">25</xref>]; Pinho-Gomes et al., 2023[<xref ref-type="bibr" rid="R69">69</xref>]; Stone et al., 2023[<xref ref-type="bibr" rid="R76">76</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]; Roh et al., 2024[<xref ref-type="bibr" rid="R71">71</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]); lower cost compared with smoking (Dunlop et al., 2016[<xref ref-type="bibr" rid="R23">23</xref>]; Patel et al., 2016[<xref ref-type="bibr" rid="R63">63</xref>]; Hong et al., 2019[<xref ref-type="bibr" rid="R35">35</xref>]; Buu et al., 2020[<xref ref-type="bibr" rid="R15">15</xref>]; Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]; Chok et al., 2023[<xref ref-type="bibr" rid="R19">19</xref>]; Freeman et al., 2023[<xref ref-type="bibr" rid="R25">25</xref>]; Pinho-Gomes et al., 2023[<xref ref-type="bibr" rid="R69">69</xref>]; Stone et al., 2023[<xref ref-type="bibr" rid="R76">76</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]); reduction in the amount of tobacco consumed (Dunlop et al., 2016[<xref ref-type="bibr" rid="R23">23</xref>]; Patel et al., 2016[<xref ref-type="bibr" rid="R63">63</xref>]; Bunch et al., 2018[<xref ref-type="bibr" rid="R14">14</xref>]; Khouja et al., 2020[<xref ref-type="bibr" rid="R43">43</xref>]; Meng and Ponce 2020[<xref ref-type="bibr" rid="R55">55</xref>]; Chok et al., 2023[<xref ref-type="bibr" rid="R19">19</xref>]; Freeman et al., 2023[<xref ref-type="bibr" rid="R25">25</xref>]; Pettigrew et al., 2023[<xref ref-type="bibr" rid="R67">67</xref>][<xref ref-type="bibr" rid="R68">68</xref>]; Pinho-Gomes et al., 2023[<xref ref-type="bibr" rid="R69">69</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]); the possibility of vaping in places where smoking is prohibited (Dunlop et al., 2016[<xref ref-type="bibr" rid="R23">23</xref>]; Patel et al., 2016[<xref ref-type="bibr" rid="R63">63</xref>]; Bunch et al., 2018[<xref ref-type="bibr" rid="R14">14</xref>]; Hong et al., 2019[<xref ref-type="bibr" rid="R35">35</xref>]; Buu et al., 2020[<xref ref-type="bibr" rid="R15">15</xref>]; Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]; Freeman et al., 2023[<xref ref-type="bibr" rid="R25">25</xref>]; Pinho-Gomes et al., 2023[<xref ref-type="bibr" rid="R69">69</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]); seeking the psychotropic effects of nicotine to cope with stress and anxiety or to concentrate (Case et al., 2020[<xref ref-type="bibr" rid="R16">16</xref>]; Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]; Newcombe et al., 2021[<xref ref-type="bibr" rid="R56">56</xref>]; Pinho-Gomes et al., 2023[<xref ref-type="bibr" rid="R69">69</xref>]; Stone et al., 2023[<xref ref-type="bibr" rid="R76">76</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]; Roh et al., 2024[<xref ref-type="bibr" rid="R71">71</xref>]); because of important close people (family, but especially friends) use them (Hong et al., 2019[<xref ref-type="bibr" rid="R35">35</xref>]; Buu et al., 2020[<xref ref-type="bibr" rid="R15">15</xref>]; Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]; Khouja et al., 2020[<xref ref-type="bibr" rid="R43">43</xref>]; Chok et al., 2023[<xref ref-type="bibr" rid="R19">19</xref>]; Pettigrew et al., 2023[<xref ref-type="bibr" rid="R67">67</xref>][<xref ref-type="bibr" rid="R68">68</xref>]; Pinho-Gomes et al., 2023[<xref ref-type="bibr" rid="R69">69</xref>]; Roh et al., 2024[<xref ref-type="bibr" rid="R71">71</xref>]); out of curiosity (Patel et al., 2016[<xref ref-type="bibr" rid="R63">63</xref>]; Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]; Khouja et al., 2020[<xref ref-type="bibr" rid="R43">43</xref>]; Meng and Ponce, 2020[<xref ref-type="bibr" rid="R55">55</xref>]; Chok et al., 2023[<xref ref-type="bibr" rid="R19">19</xref>]; Freeman et al., 2023[<xref ref-type="bibr" rid="R25">25</xref>]; Pettigrew et al., 2023[<xref ref-type="bibr" rid="R67">67</xref>][<xref ref-type="bibr" rid="R68">68</xref>]; Pinho-Gomes et al., 2023[<xref ref-type="bibr" rid="R69">69</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]); the taste of vaping was perceived as more pleasant than that of smoking (Dunlop et al., 2016[<xref ref-type="bibr" rid="R23">23</xref>]; Hong et al., 2019[<xref ref-type="bibr" rid="R35">35</xref>]; Freeman et al., 2023[<xref ref-type="bibr" rid="R25">25</xref>]; Pettigrew et al., 2023[<xref ref-type="bibr" rid="R67">67</xref>][<xref ref-type="bibr" rid="R68">68</xref>]; Pinho-Gomes et al., 2023[<xref ref-type="bibr" rid="R69">69</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]) and because it is a fun and enjoyable practice (Dunlop et al., 2016[<xref ref-type="bibr" rid="R23">23</xref>]; Hong et al., 2019[<xref ref-type="bibr" rid="R35">35</xref>]; Freeman et al., 2023[<xref ref-type="bibr" rid="R25">25</xref>]; Pettigrew et al., 2023[<xref ref-type="bibr" rid="R67">67</xref>][<xref ref-type="bibr" rid="R68">68</xref>]; Pinho-Gomes et al., 2023[<xref ref-type="bibr" rid="R69">69</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]). To a lesser extent, the following reasons were reported: to appear cool (Jongenelis et al., 2019[<xref ref-type="bibr" rid="R40">40</xref>]; Case et al., 2020[<xref ref-type="bibr" rid="R16">16</xref>]; Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]; Chok et al., 2023[<xref ref-type="bibr" rid="R19">19</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]); the better smell it produces (Hong et al., 2019[<xref ref-type="bibr" rid="R35">35</xref>]; Chok et al., 2023[<xref ref-type="bibr" rid="R19">19</xref>]) or the absence of (bad) smell compared to smoking (Patel et al., 2016[<xref ref-type="bibr" rid="R63">63</xref>]; Buu et al., 2020[<xref ref-type="bibr" rid="R15">15</xref>]; Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]; Pinho-Gomes et al., 2023[<xref ref-type="bibr" rid="R69">69</xref>]; Stone et al., 2023[<xref ref-type="bibr" rid="R76">76</xref>]); the practicality of use (Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]; Newcombe et al., 2021[<xref ref-type="bibr" rid="R56">56</xref>]; Chok et al., 2023[<xref ref-type="bibr" rid="R19">19</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]). Vaping facilitated social interactions and integration (Buu et al., 2020[<xref ref-type="bibr" rid="R15">15</xref>]; Case et al., 2020[<xref ref-type="bibr" rid="R16">16</xref>]; Meng and Ponce, 2020[<xref ref-type="bibr" rid="R55">55</xref>]; Newcombe et al., 2021[<xref ref-type="bibr" rid="R56">56</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]); it was described as more acceptable than smoking (Hong et al., 2019[<xref ref-type="bibr" rid="R35">35</xref>]; Pinho-Gomes et al., 2023[<xref ref-type="bibr" rid="R69">69</xref>]; Stone et al., 2023[<xref ref-type="bibr" rid="R76">76</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]), especially by non-smokers (Patel et al., 2016[<xref ref-type="bibr" rid="R63">63</xref>]; Hong et al., 2019[<xref ref-type="bibr" rid="R35">35</xref>]; Buu et al., 2020[<xref ref-type="bibr" rid="R15">15</xref>]). Young adults have also described the following reasons: the similarities between vaping and smoking (Patel et al., 2016[<xref ref-type="bibr" rid="R63">63</xref>]; Hong et al., 2019[<xref ref-type="bibr" rid="R35">35</xref>]; Buu et al., 2020[<xref ref-type="bibr" rid="R15">15</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]); the appeal of advertising (Hong et al., 2019[<xref ref-type="bibr" rid="R35">35</xref>]; Buu et al., 2020[<xref ref-type="bibr" rid="R15">15</xref>]; Stone et al., 2023[<xref ref-type="bibr" rid="R76">76</xref>]), especially on social networks (Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]); seeing people vaping in public and in the media (Hong et al., 2019[<xref ref-type="bibr" rid="R35">35</xref>]; Buu et al., 2020[<xref ref-type="bibr" rid="R15">15</xref>]; Roh et al., 2024[<xref ref-type="bibr" rid="R71">71</xref>]); discretion of use (Chok et al., 2023[<xref ref-type="bibr" rid="R19">19</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]; Roh et al., 2024[<xref ref-type="bibr" rid="R71">71</xref>]), especially because e-cigarette use could be hidden from adults (Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]); for appetite or weight control (Case et al., 2020[<xref ref-type="bibr" rid="R16">16</xref>]; Newcombe et al., 2021[<xref ref-type="bibr" rid="R56">56</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]), for an energy boost (Case et al., 2020[<xref ref-type="bibr" rid="R16">16</xref>]; Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]; Newcombe et al., 2021[<xref ref-type="bibr" rid="R56">56</xref>]) or just for a nicotine hit (Case et al., 2020[<xref ref-type="bibr" rid="R16">16</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]; Roh et al., 2024[<xref ref-type="bibr" rid="R71">71</xref>]); for the possibility of personalizing use (Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]; Chok et al., 2023[<xref ref-type="bibr" rid="R19">19</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]); for preventing smoking relapse (Pinho-Gomes et al., 2023[<xref ref-type="bibr" rid="R69">69</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]) or smoking initiation (Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]); for ease of purchase (Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]; Roh et al., 2024[<xref ref-type="bibr" rid="R71">71</xref>]), transportation (Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]), or refilling (Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]); as a way to reduce the risks associated with tobacco (Case et al., 2020[<xref ref-type="bibr" rid="R16">16</xref>]), such as consuming less nicotine (Chok et al., 2023[<xref ref-type="bibr" rid="R19">19</xref>]); to manage cravings (Patel et al., 2016[<xref ref-type="bibr" rid="R63">63</xref>]; Khouja et al., 2020[<xref ref-type="bibr" rid="R43">43</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]); to avoid going out to smoke (Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]); to take a few puffs without having to finish a cigarette (Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]); the lower perceived addictiveness compared to tobacco (Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]); the opportunity to do vaping tricks (Roh et al., 2024[<xref ref-type="bibr" rid="R71">71</xref>]); to appear more mature (Case et al., 2020[<xref ref-type="bibr" rid="R16">16</xref>]); to manage symptoms of a chronic disease such as headaches (Newcombe et al., 2021[<xref ref-type="bibr" rid="R56">56</xref>]); because they had received a discount coupon for their purchase (Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]). Young adults also reported frequently using e-cigarettes while drinking alcohol (Newcombe et al., 2021[<xref ref-type="bibr" rid="R56">56</xref>]).</p><p>Three quantitative studies have examined the reasons for continued use of e-cigarettes based on smoking status. The results of these studies are inconsistent. In one study, the taste of e-cigarettes and the appeal of flavors were the main reasons reported by both smokers and nonsmokers (Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]). In another study, viewing vaping as fun or pleasurable was the main reason reported regardless of smoking status (Jongenelis et al., 2019[<xref ref-type="bibr" rid="R40">40</xref>]). Finally, in the third study, quitting and then reducing smoking were the top two reasons for continued use among 23-year-old young adults who had smoked tobacco before vaping (Khouja et al., 2020[<xref ref-type="bibr" rid="R43">43</xref>]).</p><p>According to the seven qualitative studies and the qualitative component of the mixed methods study, the reasons for continuing to use e-cigarettes varied. They could be used to quit smoking (Cheney et al., 2016[<xref ref-type="bibr" rid="R17">17</xref>]; Vu et al., 2018[<xref ref-type="bibr" rid="R85">85</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]) or to reduce tobacco smoking (Cheney et al., 2016[<xref ref-type="bibr" rid="R17">17</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]). Young adult tobacco smokers also used e-cigarettes to manage signs of a tobacco use disorder or to reduce physical complications associated with chronic use: to prevent relapse after quitting smoking (Cheney et al., 2016[<xref ref-type="bibr" rid="R17">17</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]), to manage withdrawal symptoms (Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]) or to preserve their lungs or voice (Cheney et al., 2016[<xref ref-type="bibr" rid="R17">17</xref>]; Hoek et al., 2017[<xref ref-type="bibr" rid="R34">34</xref>]; Kava et al., 2021[<xref ref-type="bibr" rid="R41">41</xref>]; Robertson et al., 2022[<xref ref-type="bibr" rid="R70">70</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]). Some participants who perceived advantages of vaping over smoking favored continued use of e-cigarettes: perceived less harm (Vu et al., 2018[<xref ref-type="bibr" rid="R85">85</xref>]; Kava et al., 2021[<xref ref-type="bibr" rid="R41">41</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]); lower cost than smoking  (Hoek et al., 2017[<xref ref-type="bibr" rid="R34">34</xref>]; Robertson et al., 2022[<xref ref-type="bibr" rid="R70">70</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]); vaping in places where smoking is prohibited (Vu et al., 2018[<xref ref-type="bibr" rid="R85">85</xref>]; Kechter et al., 2022[<xref ref-type="bibr" rid="R42">42</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]); absence of odor (Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]); less disruptive than tobacco to those around them (Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]). Some vaped for the effects of nicotine: to cope with stress or improve concentration (Cheney et al., 2016[<xref ref-type="bibr" rid="R17">17</xref>]; Cooper et al., 2016[<xref ref-type="bibr" rid="R20">20</xref>]; Vu et al., 2018[<xref ref-type="bibr" rid="R85">85</xref>]; Kava et al., 2021[<xref ref-type="bibr" rid="R41">41</xref>]; Robertson et al., 2022[<xref ref-type="bibr" rid="R70">70</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]); to control appetite (Robertson et al., 2022[<xref ref-type="bibr" rid="R70">70</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]) or negative emotions (Robertson et al., 2022[<xref ref-type="bibr" rid="R70">70</xref>]). While some young adult smokers used e-cigarettes as an alternative to cigarettes, trying to maintain smoking rituals or rhythms (Hoek et al., 2017[<xref ref-type="bibr" rid="R34">34</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]), others used vaping as a way to move away from smoking by adopting a new practice (Hoek et al., 2017[<xref ref-type="bibr" rid="R34">34</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]); they may use their electronic devices as a marker of identity (Robertson et al., 2022[<xref ref-type="bibr" rid="R70">70</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]) or develop a vaping expertise that they share (Hoek et al., 2017[<xref ref-type="bibr" rid="R34">34</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]). Young adults reported vaping for fun  (Cheney et al., 2016[<xref ref-type="bibr" rid="R17">17</xref>]) or to pass the time&#x2F;relieve boredom (Cheney et al., 2016; Robertson et al., 2022[<xref ref-type="bibr" rid="R70">70</xref>]). The technological features of electronic devices (Cooper et al., 2016[<xref ref-type="bibr" rid="R20">20</xref>]) and the possibility of vaping tricks (Cheney et al., 2016[<xref ref-type="bibr" rid="R17">17</xref>]; Cooper et al., 2016[<xref ref-type="bibr" rid="R20">20</xref>]; Kava et al., 2021[<xref ref-type="bibr" rid="R41">41</xref>]) contributed to vaping for fun. Vaping tricks had also allowed some of them to gain visibility and recognition as artistic performers (Robertson et al., 2022[<xref ref-type="bibr" rid="R70">70</xref>]). Continuing to vape was also justified by its usefulness in starting conversations with strangers (Cheney et al., 2016[<xref ref-type="bibr" rid="R17">17</xref>]), and maintaining social connections with smoking friends (Hoek et al., 2017[<xref ref-type="bibr" rid="R34">34</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]). Vaping facilitated social interactions (Kava et al., 2021[<xref ref-type="bibr" rid="R41">41</xref>]; Robertson et al., 2022[<xref ref-type="bibr" rid="R70">70</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]); it also allowed integration within a group of smoking peers (Robertson et al., 2022[<xref ref-type="bibr" rid="R70">70</xref>]). Some reasons for continuing to vape were related to the characteristics of e-cigarettes and e-liquids (and not related to tobacco smoking): the appeal of the variety of flavors (Cheney et al., 2016[<xref ref-type="bibr" rid="R17">17</xref>]; Cooper et al., 2016[<xref ref-type="bibr" rid="R20">20</xref>]; Vu et al., 2018[<xref ref-type="bibr" rid="R85">85</xref>]; Kava et al., 2021[<xref ref-type="bibr" rid="R41">41</xref>]; Robertson et al., 2022[<xref ref-type="bibr" rid="R70">70</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]); the possibility to customize e-cigarette use (Cheney et al., 2016[<xref ref-type="bibr" rid="R17">17</xref>]; Cooper et al., 2016[<xref ref-type="bibr" rid="R20">20</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]), especially through &#x201C;do-it-yourself&#x201D; (or DIY) (Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]), the features of e-cigarettes  (Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]) or their design (Kava et al., 2021[<xref ref-type="bibr" rid="R41">41</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]). Some young adults also cited ease of use (Kechter et al., 2022[<xref ref-type="bibr" rid="R42">42</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]) and pleasure (Robertson et al., 2022[<xref ref-type="bibr" rid="R70">70</xref>]; Kinouani et al., 2024[<xref ref-type="bibr" rid="R45">45</xref>]) as reasons for use. Some qualitative studies identified several actors who encouraged continued vaping: family or friends who provided the first e-cigarette (Cheney et al., 2016[<xref ref-type="bibr" rid="R17">17</xref>]), peers (Robertson et al., 2022[<xref ref-type="bibr" rid="R70">70</xref>]) or celebrities (Kava et al., 2021[<xref ref-type="bibr" rid="R41">41</xref>]). One study also identified features of student life that might encourage continued use of e-cigarettes: greater perceived freedom, more social events, especially when alcohol use is encouraged (Kava et al., 2021[<xref ref-type="bibr" rid="R41">41</xref>]).</p><p>As shown in Supplementary information (Table S4), the most common extrinsic factors reported in the articles for continued e-cigarette use were the appeal of e-liquid flavors and the ability to vape where smoking is prohibited. The studies also highlighted the practicality&#x2F;ease of use, possibility to customize use and social integration or acceptability as extrinsic factors commonly reported to support continued use. Smoking cessation or reduction, less harm and lower cost compared to smoking and seeking the psychotropic effects of nicotine were the most commonly reported intrinsic factors for continued use.</p></sec><sec><title>Robustness analysis</title><p>In the second analysis, 16 articles of low global quality assessment  (Lotrean, 2015[<xref ref-type="bibr" rid="R52">52</xref>]; Dunlop et al., 2016[<xref ref-type="bibr" rid="R23">23</xref>]; Martinasek et al., 2018[<xref ref-type="bibr" rid="R53">53</xref>]; Hong et al., 2019[<xref ref-type="bibr" rid="R35">35</xref>]; Jongenelis et al., 2019[<xref ref-type="bibr" rid="R40">40</xref>]; Case et al., 2020[<xref ref-type="bibr" rid="R16">16</xref>]; Ickes et al., 2020[<xref ref-type="bibr" rid="R39">39</xref>]; Tamulevicius et al., 2020[<xref ref-type="bibr" rid="R78">78</xref>]; Newcombe et al., 2021[<xref ref-type="bibr" rid="R56">56</xref>]; Chok et al., 2023[<xref ref-type="bibr" rid="R19">19</xref>]; Freeman et al., 2023[<xref ref-type="bibr" rid="R25">25</xref>]; Obisesan et al., 2023[<xref ref-type="bibr" rid="R58">58</xref>]; Stone et al., 2023[<xref ref-type="bibr" rid="R76">76</xref>]; Roh et al., 2024[<xref ref-type="bibr" rid="R71">71</xref>]; Thoonen and Jongenelis, 2024[<xref ref-type="bibr" rid="R79">79</xref>]) or with a conflict of interest statement (Kava et al., 2021[<xref ref-type="bibr" rid="R41">41</xref>]) were removed from the systematic review. As shown in Supplementary information (Tables S5 and S6), results were similar to the main analyses regarding the most commonly reported intrinsic, sociocultural or structural reasons for e-cigarette use, whether for its initiation or for its continuation.</p></sec></sec>
    <sec sec-type="discussion">
      <title>Discussion</title><p>In this review, we found that young adults combined intrinsic and extrinsic reasons for using e-cigarettes. A category of extrinsic reasons related to vaping products and their features emerged during our data synthesis. The appeal of e-liquid flavors was one of the reasons from this same category that was very frequently cited as encouraging both experimentation and continued use of e-cigarettes. Quitting smoking or perceiving vaping as less harmful than smoking were the most reported intrinsic reasons for initiating e-cigarette use. Young adults also reported doing so out of curiosity (regardless of their smoking status) or as an opportunity in the presence of other vapers. For continued e-cigarette use, the most reported intrinsic reasons in studies were quitting or reducing smoking, perceived benefits of vaping over smoking (lower cost, less perceived harm), and seeking the psychotropic effects of nicotine. The ability to vape where smoking is prohibited, convenience&#x2F; ease of use, ability to customize use, social acceptability, and social facilitation were the most reported as extrinsic reasons for continued use.</p><p>We found it was necessary to individualize the extrinsic reasons associated with vaping product features during data synthesis. Other studies have also found that the characteristics of e-liquids and electronic devices promote e-cigarette use (Harvanko et al., 2018[<xref ref-type="bibr" rid="R33">33</xref>]; Alqahtani et al., 2022[<xref ref-type="bibr" rid="R1">1</xref>]), particularly flavor variety (Huang et al., 2017[<xref ref-type="bibr" rid="R38">38</xref>]; Kowitt et al., 2017[<xref ref-type="bibr" rid="R47">47</xref>]; Gendall and Hoek 2021[<xref ref-type="bibr" rid="R29">29</xref>]). Flavor seems to be very important to young adults (Bonhomme et al., 2016[<xref ref-type="bibr" rid="R11">11</xref>]; Cooper et al., 2016[<xref ref-type="bibr" rid="R20">20</xref>]; Patel et al., 2016[<xref ref-type="bibr" rid="R63">63</xref>]; Buckell and Sindelar 2019[<xref ref-type="bibr" rid="R13">13</xref>]; Baker et al., 2021[<xref ref-type="bibr" rid="R9">9</xref>]; Whaley et al., 2024[<xref ref-type="bibr" rid="R88">88</xref>]), who are more likely than older adults to cite it as a reason for using e-cigarettes (Bonhomme et al., 2016[<xref ref-type="bibr" rid="R11">11</xref>]; Cooper et al., 2016[<xref ref-type="bibr" rid="R20">20</xref>]; Patel et al., 2016[<xref ref-type="bibr" rid="R63">63</xref>]). The role of e-liquid flavors in vaping initiation is even more important to monitor because there is insufficient evidence that they also promote smoking cessation among tobacco smokers (Huang et al., 2017[<xref ref-type="bibr" rid="R38">38</xref>]; Zare et al., 2018[<xref ref-type="bibr" rid="R91">91</xref>]). Although some studies suggest that non-tobacco flavored e-liquids may promote smoking cessation more than tobacco flavored e-liquids (Brandon et al., 2019[<xref ref-type="bibr" rid="R12">12</xref>]; Friedman and Xu, 2020[<xref ref-type="bibr" rid="R27">27</xref>]; Gravely et al., 2020[<xref ref-type="bibr" rid="R30">30</xref>]; Harlow et al., 2022[<xref ref-type="bibr" rid="R32">32</xref>]), the risk-benefit balance remains to be determined. It needs to be confirmed by further studies.</p><p>Sociocultural extrinsic factors have previously been described as promoting the use of e-cigarettes among adults (Soule et al., 2016[<xref ref-type="bibr" rid="R73">73</xref>]; Wadsworth et al., 2016[<xref ref-type="bibr" rid="R87">87</xref>]; Nicksic et al., 2019[<xref ref-type="bibr" rid="R57">57</xref>]; Yong et al., 2019[<xref ref-type="bibr" rid="R90">90</xref>]; Amin et al., 2020[<xref ref-type="bibr" rid="R2">2</xref>]). Our findings suggest that social acceptability is a well-identified factor for maintaining e-cigarette use among young adults, while having e-cigarette users in one&#x27;s social circle promotes both initiation and continuation of vaping. Conversely, few of the included studies described structural extrinsic reasons as determinants of e-cigarette use, as if young adults did not spontaneously identify them as such. The two main structural reasons described by young adults were the ability to vape where smoking is prohibited and exposure to advertising for vaping products. This is consistent with findings from some studies not limited to young adults (Wadsworth et al., 2016[<xref ref-type="bibr" rid="R87">87</xref>]; Kim et al., 2017[<xref ref-type="bibr" rid="R44">44</xref>]; Lee et al., 2018[<xref ref-type="bibr" rid="R50">50</xref>]; Cheng et al., 2019[<xref ref-type="bibr" rid="R18">18</xref>]; Amin et al., 2020[<xref ref-type="bibr" rid="R2">2</xref>]). Other studies have shown that e-cigarette regulatory policies subsequently affect e-cigarette or tobacco use among young adults. A longitudinal study of more than 17,000 Americans aged 18 to 24 conducted between 2014 and 2019 found that current e-cigarette use increased overall during this period, but the increase was less rapid in American states with vaping product excise tax policies (Han et al., 2023[<xref ref-type="bibr" rid="R31">31</xref>]). Another study showed that increasing taxes on e-cigarettes decreased e-cigarette use among Americans aged 18 to 25, but increased their use of tobacco cigarettes (Friedman and Pesko, 2022[<xref ref-type="bibr" rid="R26">26</xref>]). A study was conducted in 2021 among 18-34-year-old Americans who vaped flavored e-liquids. The study explored their attitudes toward a restriction on the sale of flavors (whether this restriction was in effect in their state or hypothetical). In the context of an actual or hypothetical ban on flavors in e-liquids, nearly 80 &#x25; said they would continue to vape; 12.5 &#x25; of those who exclusively vaped prior to an effective flavor restriction had switched to tobacco products (Tam et al., 2024[<xref ref-type="bibr" rid="R77">77</xref>]). Finally, a study conducted simultaneously in Canada, Australia and the UK showed a differential impact of regulating nicotine levels in vaping products on tobacco use among young adults. In most Canadian provinces where higher nicotine levels were allowed in vaping products, the introduction of vaping led to a reduction in smoking prevalence. In the UK where the maximum nicotine level allowed in vaping products was 20 mg&#x2F;ml, the introduction of vaping slowed the declining trend in cigarette prevalence among men aged 16-34. In Australia, where nicotine was not permitted in e-cigarettes, the introduction of e-cigarettes slowed the declining trend in smoking prevalence among men aged 18-24 years (Wu et al., 2022[<xref ref-type="bibr" rid="R89">89</xref>]). These different studies show that policies regulating vaping products influence young adults&#x27; use of e-cigarettes, even if they do not realize it. However, it seems relevant to combine several policies regulating vaping products to act on different levers, and also to assess their impact taking into account the evolution of tobacco use.</p><p>There is no universal definition of who is a young adult. For psychologists such as Arnett, the transition to adulthood is no longer defined by social events such as marriage or the onset of parenthood since the mid-20th century. This transition is now more dependent on individual psychological development, which begins during adolescence but peaks during a distinct stage of life that Arnett has termed &#x22;emerging adulthood&#x22; (Arnett, 2000[<xref ref-type="bibr" rid="R3">3</xref>], 2024[<xref ref-type="bibr" rid="R4">4</xref>]). He initially placed this phase between the ages of 18 and 25 (Arnett, 2000[<xref ref-type="bibr" rid="R3">3</xref>]), before later extending it to the period between 18 and 29 (Arnett, 2000[<xref ref-type="bibr" rid="R3">3</xref>], 2007[<xref ref-type="bibr" rid="R5">5</xref>], 2024[<xref ref-type="bibr" rid="R4">4</xref>]; Arnett et al., 2014[<xref ref-type="bibr" rid="R7">7</xref>]). Sociologists have made a nearly analogous observation regarding the desynchronization of social markers of transition in the young adult population of industrialized countries. What distinguishes them from psychologists such as Arnett is the emphasis that they place on extrinsic factors in the development of personal trajectories (Van de Velde, 2008[<xref ref-type="bibr" rid="R83">83</xref>]; Galland, 2022[<xref ref-type="bibr" rid="R28">28</xref>]). Describing the trajectory of e-cigarette use among 18-30-year-olds allows psychologists and sociologists to partially converge. As we hypothesized, both experimentation and continued use of e-cigarettes among young adults seemed to be justified by a combination of extrinsic and intrinsic reasons. Their decision to vape is certainly a personal choice but one that is made possible by the national framework that regulates the sale and use of vaping products, particularly the price and the availability of nicotine or flavors in e-liquids.</p><p>This review, likely to be one of the most up-to-date explorations of the reasons for e-cigarette use among young adults, may not be exhaustive. Efforts were made to include a wide range of studies by diversifying database searches, incorporating gray literature, and considering all study designs. Nonetheless, several limitations should be acknowledged. It included many cross-sectional studies conducted on convenience and non-representative samples. Therefore, the performed data synthesis is mainly a qualitative description of the reasons for using e-cigarettes. The generalizability of the findings in low- and middle-income countries is also limited by the preponderance of American studies. Definitions of e-cigarette use varied across the included studies, especially for continuous use. If information was missing during the full reading of the articles, we tried to find this information by reading the protocols or going to the websites of the studies. If the information remained missing, the study was excluded, but we could have contacted the authors of the articles before deciding on their exclusion. The quality of reporting of the articles was assessed by a single reviewer. Finally, the distinction between intrinsic, sociocultural, structural and vaping product feature reasons is fictitious. For example, seeing celebrities vaping on television or in reviews is both a matter of social acceptability and tolerance on the part of policymakers to encourage use through less restrictive regulation.</p></sec>
    <sec sec-type="conclusions">
      <title>Conclusion</title><p>Despite its limitations, this research represents the first comprehensive overview of the diverse reasons for e-cigarette use among 18-30-year-olds. It underscores the importance of distinguishing between reasons for initiation and continued use, highlighting that these motivations are varied and often interconnected. Additionally, it demonstrates that young adults do not solely perceive e-cigarettes as a smoking cessation tool. </p><p>To better address this behavior, health professionals should explore the reasons for e-cigarette use through open-ended questions, allowing for a more nuanced understanding of the diverse motivational factors at play. This approach could provide valuable insights into the complex trajectories of e-cigarette use in this population.</p><p>While intrinsic reasons were frequently cited in the studies, young adults rarely acknowledged the structural context as a decisive factor. However, this context likely plays a significant role in shaping the motivations for initiating or continuing e-cigarette use, as it is influenced by each country&#x27;s regulatory policies governing the sale, use, and promotion of tobacco and vaping products. Future research, particularly qualitative studies, should focus on exploring young adults&#x27; awareness of, adherence to, or resistance against these regulatory frameworks. This could provide valuable insights into how structural factors influence vaping behavior and how such behavior evolves in response to policy changes.</p></sec>
    <sec>
      <title>Declaration</title><sec><title>Acknowledgments</title><p>The authors would like to thank Ms. H&#xE9;l&#xE8;ne Plouseau-Gu&#xE9;d&#xE9; for her assistance in selecting databases. They also thank Ms. Jacqueline Pedley for English language copyediting and Mr. Paul Vanderkam for his advice on the protocol. During the preparation of this work, the authors used DeepL Write&#xAE; (software with artificial intelligence) to copyedit the manuscript. After using this tool, the authors revised the content as needed and they take full responsibility for the content of the publication.</p></sec><sec><title>Conflict of interest</title><p>The authors declare that they have no conflict of interest.</p></sec><sec><title>Authors&#x27; contribution</title><p>SK, MA, and CT conceptualized the study and drafted the initial manuscript. SK, FR, BQ performed data screening, extraction and analyses. They were also responsible for quality assessment. SK performed data synthesis. All authors approved the final version of the manuscript.</p></sec></sec>
    <sec sec-type="supplementary-material">
      <title>Supplementary Material</title>
      <supplementary-material id="SD1" content-type="local-data">
        <caption>
          <title>Supplementary information</title>
        </caption>
        <media mimetype="application" mime-subtype="application/pdf" xlink:href="EXCLI-24-204-s-001.pdf" />
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  <floats-wrap>
    <fig id="T1" position="float">
      <label>Table 1</label>
      <caption><title>Search strategy</title></caption>
      <graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="EXCLI-24-204-t-001" />
    </fig>
    <fig id="T2" position="float">
      <label>Table 2</label>
      <caption><title>Characteristics of the included studies</title></caption>
      <graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="EXCLI-24-204-t-002" />
    </fig>
    <fig id="T3" position="float">
      <label>Table 3</label>
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      <graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="EXCLI-24-204-t-003" />
    </fig>
    <fig id="T4" position="float">
      <label>Table 4</label>
      <caption><title>Description of studies examining reasons for continuing use of e-cigarettes among 18-30-year-olds</title></caption>
      <graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="EXCLI-24-204-t-004" />
    </fig>
    <fig id="F1" position="float">
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      <graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="EXCLI-24-204-g-001" />
    </fig>
  </floats-wrap>
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