Baicalein (5,6,7-trihydroxyflavone) is a representative flavone found in Scutellaria spp., particularly Scutellaria baicalensis and S. lateriflora (Zhu et al., 2024[24]) Baicalein can be biosynthesized from phenylalanine, an initial precursor, with serial enzymatic reactions mediated by phenylalanine ammonialyase, cinnamate 4-hydroxylase, cinnamate-CoA ligase, chalcone synthase, chalcone isomerase, flavone synthase II, and flavone 6-hydroxylase (Yeo et al., 2025[22]). Baicalein is beneficial to human health owing to its antioxidant, anti-inflammatory, anti-cancer, anti-diabetic, antimicrobial, anti-aging, cardioprotective, neuroprotective, respiratory-protective, gastroprotective, liver-protective, and kidney-protective effects (Munjal et al., 2024[15]). In particular, baicalein has received attention as an antitumor agent owing to its high efficacy and low toxicity in the treatment of malignant tumors (Lei et al., 2024[11]). This letter provides an overview of the recent studies conducted to assess the biological and pharmacological properties of baicalein (Table 1(Tab. 1); References in Table 1: Chen et al., 2024[1]; Chi et al., 2025[2]; Dong et al., 2024[3]; Du et al., 2025[4]; Fang et al., 2024[5]; Guo et al., 2024[6]; Hao et al., 2025[7]; Huang et al., 2024[8]; Jin et al., 2024[9]; Lai et al., 2024[10]; Li et al., 2024[13], 2025[12]; Liu et al., 2024[14]; Park et al., 2024[16]; Ren et al., 2024[17]; Wang et al., 2024[18], 2024[19], 2025[20]; Xu et al., 2025[21]; Zhang et al., 2025[23]).