Sodium-glucose cotransporter 2 inhibitors and mitochondrial functions
state of the art
Keywords:sodium-glucose cotransporter 2 inhibitors, mitochondria, diabetes mellitus, mitophagy, oxidative stress
Sodium-glucose cotransporter 2 inhibitors (SGLT2is) are a class of newly introduced antidiabetic drugs with potent hypoglycemic effects. Recent evidence suggests that these drugs have extraglycemic impacts and are therefore able to provide additional benefits beyond glucose lowering. Mitochondrial dysfunction is a central facet of many disorders that negatively impacts many tissues and organs, especially in the setting of diabetes. Therefore, it would be hugely beneficial if an antidiabetic drug could also provide mitochondrial benefits to improve cellular function and reduce the risk of diabetic complications. In this review, we have surveyed the literature for possible mitochondrial benefits of SGLT2is and we discuss the possible mechanisms involved.
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Copyright (c) 2023 Habib Yaribeygi, Mina Maleki, Alexandra E. Butler, Tannaz Jamialahamdi, Amirhossein Sahebkar
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