The role of glutamatergic pathway between septum and hippocampus in the memory formation

Authors

  • Fatemeh Khakpai Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
  • Mohammad Reza Zarrindast Department of Neuroscience, School of Advance Medical Technologies, Tehran University of Medical Sciences, Tehran, Iran; Department of Pharmacology School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Institute for Cognitive Science Studies (ICSS), Tehran, Iran; Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran
  • Mohammad Nasehi Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Garmsar Branch, Semnan, Iran
  • Ali Haeri-Rohani Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
  • Akram Eidi Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran

Keywords:

septum, hippocampus, septo-hippocampal, hippocampo-septal, learning, memory

Abstract

The N-methyl-D-aspartate (NMDA) receptor is a subtype of glutamate receptor that is presented in highest density in the hippocampus and septum. NMDA receptors of the septum and the hippocampus are involved in cognitive performance, especially in learning and memory processes. The septum nucleus and hippocampal formation are two regions of the limbic system. The septum and the hippocampus are anatomically and functionally connected to each other. These areas made the septo-hippocampal and hippocampo-septal pathways, which are implicated in the cognitive processes. The activity of septal and hippocampal neurons is modulated by several neurotransmitters such as glutamate. Thus, changes in the glutamatergic transmission in the septum and hippocampus may influence learning and memory processes in these pathways.

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Published

2013-01-21

How to Cite

Khakpai, F., Zarrindast, M. R., Nasehi, M., Haeri-Rohani, A., & Eidi, A. (2013). The role of glutamatergic pathway between septum and hippocampus in the memory formation. EXCLI Journal, 12, 41–51. Retrieved from https://www.excli.de/index.php/excli/article/view/1126

Issue

Vol. 12 (2013)

Section

Review articles

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