Aquaporin 4 and brain-related disorders: Insights into its apoptosis roles

Aquaporin 4 and Apoptosis

Authors

  • Ehsan Dadgostar Department of Psychiatry, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran http://orcid.org/0000-0002-4041-7324
  • Vida Tajiknia Department of Surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran https://orcid.org/0000-0002-0391-5869
  • Negar Shamsaki Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran https://orcid.org/0000-0003-0639-8956
  • Mojtaba Naderi-Taheri Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran https://orcid.org/0000-0002-6419-7469
  • Michael Aschner Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA https://orcid.org/0000-0002-2619-1656
  • Hamed Mirzaei Hamed Mirzaei, Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. E-mail: h.mirzaei2002@gmail.com; mirzaei-h@kaums.ac.ir https://orcid.org/0000-0002-9399-8281
  • Omid Reza Tamtaji Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran; E-mail: tamtaji.or@gmail.com https://orcid.org/0000-0003-2492-3996

DOI:

https://doi.org/10.17179/excli2021-3735

Keywords:

aquaporin 4, apoptosis, brain diseases

Abstract

Brain-related disorders are leading global health problems. Various internal and external factors are involved in the progression of brain-related disorders. Inflammatory pathways, oxidative stresses, apoptosis, and deregulations of various channels are critical players in brain-related disorder pathogenesis. Among these players, aquaporins (AQP) have critical roles in various physiological and pathological conditions. AQPs are water channel molecules that permit water to cross the hydrophobic lipid bilayers of cellular membranes. AQP4 is one of the important members of AQP family. AQPs are involved in controlling apoptosis pathways in brain-related disorders. In this regard, several reports have evaluated the pathological effects of AQP4 by targeting the apoptosis-related processes in brain-related disorders. Here, for the first time, we highlight the impact of AQP4 on apoptosis-related processes in brain-related disorders.

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Published

2021-06-01

How to Cite

Dadgostar, E., Tajiknia, V., Shamsaki, N., Naderi-Taheri, M., Aschner, M., Hamed Mirzaei, & Tamtaji, O. R. (2021). Aquaporin 4 and brain-related disorders: Insights into its apoptosis roles : Aquaporin 4 and Apoptosis. EXCLI Journal, 20, 983–994. https://doi.org/10.17179/excli2021-3735

Issue

Vol. 20 (2021)

Section

Review articles

License

Copyright (c) 2021 Ehsanr Dadgostar, Vida Tajiknia, Negar Shamsaki, Mojtaba Naderi-Taheri, Michael Aschner, Hamed Mirzaei, Omid Reza Tamtaji

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