Momordicine I suppresses glioma growth by promoting apoptosis and impairing mitochondrial oxidative phosphorylation

Authors

  • Ying Kao Division of Neurosurgery, Department of Surgery, Taipei City Hospital Zhongxing Branch, Taipei 10341, Taiwan; Taipei City University, Taipei 100234, Taiwan https://orcid.org/0000-0001-7513-2698
  • Chung-Hsing Chou Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan https://orcid.org/0000-0001-9584-0843
  • Li-Chun Huang Department of Biochemistry, National Defense Medical Center, Taipei 11490, Taiwan https://orcid.org/0009-0008-7662-6591
  • Chia-Kuang Tsai Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Cheng-gong Road, Taipei, Taiwan 11490. Tel: +886-2-87923311 ext 12860; Fax: +886-2-87927174, E-mail: jiakuang@mail.ndmctsgh.edu.tw https://orcid.org/0000-0001-7693-1408

DOI:

https://doi.org/10.17179/excli2023-6129

Keywords:

glioblastoma, Momordica charantia, momordicine I, oxidative phosphorylation capacity, DLGPA5

Abstract

Glioblastoma (GBM) is the most common type of primary brain tumor. Patients with GBM have poor survival outcomes. Isolated components of Momordica charantia have anticancer effects. However, the bioactivity of M. charantia extracts against GBM remains unknown. We tested four major extracts of M. charantia and found that momordicine I reduced glioma cell viability without serious cytotoxic effects on astrocytes. Momordicine I suppressed glioma cell colony formation, proliferation, migration, and invasion. Momordicine I also induced apoptosis, intracellular reactive oxygen species (ROS) production, and senescence in glioma cells. Moreover, momordicine I decreased the oxidative phosphorylation capacity of glioma cells and inhibited tumor sphere formation in temozolomide (TMZ)-resistant GBM cells. We further explored whether the antiglioma effect of momordicine I may be related to cell cycle modulation and DLGPA5 expression. Our results indicate that the cytotoxic effect of momordicine I on glioma cells suggests its potential therapeutic application to GBM treatment.

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Published

2023-06-06

How to Cite

Kao, Y., Chou, C.-H., Huang, L.-C., & Tsai, C.-K. (2023). Momordicine I suppresses glioma growth by promoting apoptosis and impairing mitochondrial oxidative phosphorylation. EXCLI Journal, 22, 482–498. https://doi.org/10.17179/excli2023-6129

Issue

Vol. 22 (2023)

Section

Original articles

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Copyright (c) 2023 Ying Kao, Chung-Hsing Chou, Li-Chun Huang, Chia-Kuang Tsai

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