Empowering personalized medicine

unleashing the potential of patient-derived explants in clinical practice

Authors

  • Oliwia Piwocka Department of Electroradiology, Poznan University of Medical Sciences, 61-701 Poznan, Poland, E-mail: oliwia.piwocka@wco.pl https://orcid.org/0000-0001-7343-9872
  • Wiktoria M. Suchorska Department of Electroradiology, Poznan University of Medical Sciences, 61-701 Poznan, Poland; Radiobiology Laboratory, Department of Medical Physics, Greater Poland Cancer Center, 61-866 Poznan, Poland https://orcid.org/0000-0003-4742-2465
  • Katarzyna Kulcenty Radiobiology Laboratory, Department of Medical Physics, Greater Poland Cancer Center, 61-866 Poznan, Poland https://orcid.org/0000-0001-8400-249X

DOI:

https://doi.org/10.17179/excli2023-6700

Keywords:

patient-derived explants, personalized medicine, individual therapy, oncology

Abstract

In recent decades, significant progress has been made in understanding the molecular characteristics of cancer and its microenvironment, leading to the development of life-saving treatments. However, patients often experience side effects from standard therapies, highlighting the need for personalized medicine. Personalized medicine aims to customize drug therapy and preventive care based on individual patients' specific requirements. The heterogeneity within tumors and among patients necessitates personalized medicine approaches. Patient-derived organoids (PDOs), xenografts (PDXs), and explants (PDEs) have emerged as valuable models for studying tumor behaviour and drug response. This paper aims to summarize the latest advancements in patient-derived explants, focusing on their potential utility in the clinic. Different methods for culturing PDEs, including the free-floating approach, the grid method, and sponge scaffolds, are discussed. These approaches provide opportunities for long-term viability, oxygen and nutrient supply, and maintenance of tissue integrity. Additionally, various solid tumor models using PDEs are highlighted, together with assays to study PDE viability, characteristics, and response to drug treatment.

Downloads

Published

2024-01-10

How to Cite

Piwocka, O., Suchorska, W. M., & Kulcenty, K. (2024). Empowering personalized medicine : unleashing the potential of patient-derived explants in clinical practice. EXCLI Journal, 23, 81–91. https://doi.org/10.17179/excli2023-6700

Issue

Vol. 23 (2024)

Section

Methods

Categories

License

Copyright (c) 2024 Oliwia Piwocka, Wiktoria M. Suchorska, Katarzyna Kulcenty

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish in this journal agree to the following terms:

  • The authors keep the copyright and grant the journal the right of first publication under the terms of the Creative Commons Attribution license, CC BY 4.0. This licencse permits unrestricted use, distribution and reproduction in any medium, provided that the original work is properly cited.
  • The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.
  • Because the advice and information in this journal are believed to be true and accurate at the time of publication, neither the authors, the editors, nor the publisher accept any legal responsibility for any errors or omissions presented in the publication. The publisher makes no guarantee, express or implied, with respect to the material contained herein.
  • The authors can enter into additional contracts for the non-exclusive distribution of the journal's published version by citing the initial publication in this journal (e.g. publishing in an institutional repository or in a book).