Protective effect of Tribulus terrestris L. fruit aqueous extracton lipid profile and oxidative stress in isoproterenol induced myocardial necrosis in male albino Wistar rats

Authors

  • K.V. Sailaja Department of Biochemistry, Sri Krishnadevaraya University, Anantapur-515003,Andhra Pradesh, India
  • V. Leela Shivaranjani Department of Biochemistry, Sri Krishnadevaraya University, Anantapur-515003,Andhra Pradesh, India
  • H. Poornima Department of Biochemistry, Sri Krishnadevaraya University, Anantapur-515003,Andhra Pradesh, India
  • S.B.Md. Rahamathulla Department of Biochemistry, Sri Krishnadevaraya University, Anantapur-515003,Andhra Pradesh, India
  • K. Lakshmi Devi Department of Biochemistry, Sri Krishnadevaraya University, Anantapur-515003,Andhra Pradesh, India

Keywords:

Tribulus terrestris L., isoproterenol, oxidative stress, lipid peroxidation, myocardial necrosis

Abstract

The objective of the present study was to evaluate the possible protective effects of Tribulus terrestris fruit aqueous extract (TTFAEt) on lipid profile and oxidative stress in isoproterenol (ISO) induced myocardial necrosis in albino Wistar rats. Albino Wistar rats were divided into normal control, TTFAEt alone treated, ISO control and pretreated (TTFAEt+ISO) groups. The extract was administered at a dose of 50 mg/kg body weight for 40 days orally by gavage and ISO was administered at a dose of 85 mg/kg body weight for two consecutive days intraperitoneally at an interval of 24 h. ISO induced myocardial infarction (MI) was confirmed by disturbances in serum lipid profile, heart tissue lipid peroxidation and antioxidant enzyme levels. There was a significant increase in the levels of serum total cholesterol (32.60 %), triglycerides (41.30 %), very low density lipoproteins (81.81 %), low density lipoproteins (84%) and phospholipids (38.88 %) and a significant decrease in the levels of high density lipoproteins (33.33 %) in the ISO control group when compared to normal controls. Additionally, there is a significant decrease in the levels of heart tissue antioxidant enzymes such as superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase and depletion of reduced glutathione, which indicates enhanced lipid peroxidation(172 %). Pretreatment with extract significantly showed a protective effect against ISO altered lipid profile, lipid peroxidation and antioxidant enzyme levels. The present study showed therapeutic effect of TTFAEt on lipid profile and oxidative stress in isoproterenol (ISO) induced myocardial necrosis in experimental rats.

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Published

2013-05-06

How to Cite

Sailaja, K., Shivaranjani, V. L., Poornima, H., Rahamathulla, S., & Devi, K. L. (2013). Protective effect of Tribulus terrestris L. fruit aqueous extracton lipid profile and oxidative stress in isoproterenol induced myocardial necrosis in male albino Wistar rats. EXCLI Journal, 12, 373–383. Retrieved from https://www.excli.de/index.php/excli/article/view/1155

Issue

Vol. 12 (2013)

Section

Original articles

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