Use of intranasal esketamine in a girl with treatment-resistant depression and autism spectrum disorders

a case report

Authors

  • Miriam Olivola Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy; ASST Pavia, Pavia, Italy https://orcid.org/0000-0003-0914-0539
  • Vincenzo Arienti Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy; ASST Pavia, Pavia, Italy https://orcid.org/0000-0001-5932-8375
  • Nicola Bassetti Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy; ASST Pavia, Pavia, Italy https://orcid.org/0000-0002-6075-5785
  • Serena Civardi Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy; ASST Pavia, Pavia, Italy https://orcid.org/0000-0003-1810-9170
  • Natascia Brondino Department of Brain and Behavioral Sciences, University of Pavia, Via Bassi 21, 27100 Pavia, Italy. Tel: +39 0382987246. E-mail: natascia.brondino@unipv.it https://orcid.org/0000-0002-3128-1592

DOI:

https://doi.org/10.17179/excli2022-4694

Keywords:

autism spectrum disorders, depression, esketamine, treatment-resistant

Abstract

Major depression is a common comorbidity in autism spectrum disorder (ASD), often difficult to identify and to treat. Autistic subjects are more at risk for suicidal thoughts and behaviors compared to typically developing peers. Unfortunately, ASD individuals are more frequently treatment-resistant and often show side-effects which reduce efficacy. Intranasal esketamine has been recently approved as an add-on medication for treatment-resistant depression (TRD), but it has never been used in ASD with comorbid major depression. Of note, a pilot study of intranasal ketamine has shown no effect on social withdrawal in ASD without depression. The present case report describes the first girl with ASD and comorbid TRD treated with intranasal esketamine.

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Published

2022-02-28

How to Cite

Olivola, M., Arienti, V., Bassetti, N., Civardi, S., & Brondino, N. (2022). Use of intranasal esketamine in a girl with treatment-resistant depression and autism spectrum disorders: a case report. EXCLI Journal, 21, 540–543. https://doi.org/10.17179/excli2022-4694

Issue

Vol. 21 (2022)

Section

Case reports

Categories

License

Copyright (c) 2022 Miriam Olivola, Vincenzo Arienti, Nicola Bassetti, Serena Civardi, Natascia Brondino

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