Emerging role of nanotechnology in treatment of non-alcoholic fatty liver disease (NAFLD)

Authors

  • Atie Moghtadaie Clinical Fellow in Gastroenterology and Hepatology, Digestive Disease Research Institute, Department of Gastroenterology and Hepatology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran https://orcid.org/0000-0002-2806-5389
  • Hamidreza Mahboobi Digestive Disease Research Institute, Department of Gastroenterology and Hepatology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran, E-mail: hamidrezamahboobi@yahoo.com https://orcid.org/0000-0002-3491-8050
  • Somayeh Fatemizadeh Department of Gastroenterology and Hepatology, Shahid Beheshti University of Medical Sciences, Tehran, Iran, E-mail: sfatemi19@gmail.com https://orcid.org/0000-0002-5280-0603
  • Mohammad Amjad Kamal Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, China; King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh; Enzymoics, 7 Peterlee place, Hebersham, NSW 2770; Novel Global Community Educational Foundation, Australia https://orcid.org/0000-0003-0088-0565

DOI:

https://doi.org/10.17179/excli2023-6420

Keywords:

non-alcoholic fatty liver disease, NAFLD, MAFLD, nanotechnology, nanoemulsions, inorganic nanoparticles, polymeric nanoparticles

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a prevailing health challenge that requires urgent innovative interventions. This review explores the role of nanotechnology as a promising potential in the treatment of NAFLD. It delineates the limitations of the current management strategies for NAFLD and highlights the new nanotechnology-based treatments including nanoemulsions, liposomes, micelles, polymeric nanoparticles, nanogels, inorganic nanoparticles, and zinc oxide nanoparticles. Despite the optimism surrounding the nanotechnological approach, the review underscores the need to address the limitations such as technical challenges, potential toxicity, and ethical considerations that impede the practical application of nanotechnology in NAFLD management. It advocates for collaborative efforts from researchers, clinicians, ethicists, and policymakers to achieve safe, effective, and equitable nanotechnology-based treatments for NAFLD.

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Published

2023-09-04

How to Cite

Moghtadaie, A., Mahboobi, H., Fatemizadeh, S., & Kamal, M. A. (2023). Emerging role of nanotechnology in treatment of non-alcoholic fatty liver disease (NAFLD). EXCLI Journal, 22, 946–974. https://doi.org/10.17179/excli2023-6420

Issue

Vol. 22 (2023)

Section

Review articles

Categories

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Copyright (c) 2023 Atie Moghtadaie, Hamidreza Mahboobi, Somayeh Fatemizadeh, Mohammad Amjad Kamal

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