Atrial natriuretic peptide gene - a potential biomarker for long QT syndrome

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Sameera Fatima Qureshi
Altaf Ali
Ananthapur Venkateshwari
Hygriv Rao
M. P. Jayakrishnan
Calambur Narasimhan
Jayaprakash Shenthar
Kumarasamy Thangaraj
Pratibha Nallari

Abstract

This study highlights the possible implication of NPPA (natriuretic peptide precursor A) gene in the etiology of Long QT syndrome (LQTS) by population-based as well as familial study. Three SNPs of NPPA - C-664G, C1363A and T1766C were examined by molecular analyses in LQTS, controls and first degree relatives (FDRs). This study revealed a possible association of 1364 C>A SNP ā€˜Cā€™ allele with LQTS (p = 0.0013). All three SNPs were in tight linkage disequilibrium. The familial study highlights the association of NPPA SNP with cLQTS and implicating it as a potential biomarker in South Indian population.

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How to Cite
Qureshi, S. F., Ali, A., Venkateshwari, A., Rao, H., Jayakrishnan, M. P., Narasimhan, C., Shenthar, J., Thangaraj, K., & Nallari, P. (2014). Atrial natriuretic peptide gene - a potential biomarker for long QT syndrome. EXCLI Journal, 13, 834-842. Retrieved from https://www.excli.de/index.php/excli/article/view/745
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Original articles