Atrial natriuretic peptide gene - a potential biomarker for long QT syndrome

Authors

  • Sameera Fatima Qureshi Department of Genetics, University College of Science, Osmania University, Hyderabad-500007, Andhra Pradesh, India
  • Altaf Ali Department of Genetics, University College of Science, Osmania University, Hyderabad-500007, Andhra Pradesh, India
  • Ananthapur Venkateshwari Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Andhra Pradesh, India
  • Hygriv Rao Institute of Genetics and Krishna Institute of Medical Sciences, Andhra Pradesh, India
  • M. P. Jayakrishnan Institute of Maternal and Child Health, Calicut Medical College, Calicut 8, Kerala, India
  • Calambur Narasimhan Care Hospital, Hyderabad, Andhra Pradesh, India
  • Jayaprakash Shenthar Sri Jayadeva Institute of Cardiovascular Science and Research, Karnataka, India
  • Kumarasamy Thangaraj Centre for Cellular and Molecular Biology, Andhra Pradesh, India
  • Pratibha Nallari Department of Genetics, University College of Science, Osmania University, Hyderabad-500007, Andhra Pradesh, India

Keywords:

atrial natriuretic peptide, long QT syndrome, cardiogenesis, biomarker, polymorphisms

Abstract

This study highlights the possible implication of NPPA (natriuretic peptide precursor A) gene in the etiology of Long QT syndrome (LQTS) by population-based as well as familial study. Three SNPs of NPPA - C-664G, C1363A and T1766C were examined by molecular analyses in LQTS, controls and first degree relatives (FDRs). This study revealed a possible association of 1364 C>A SNP ‘C’ allele with LQTS (p = 0.0013). All three SNPs were in tight linkage disequilibrium. The familial study highlights the association of NPPA SNP with cLQTS and implicating it as a potential biomarker in South Indian population.

Downloads

Published

2014-08-13

How to Cite

Qureshi, S. F., Ali, A., Venkateshwari, A., Rao, H., Jayakrishnan, M. P., Narasimhan, C., … Nallari, P. (2014). Atrial natriuretic peptide gene - a potential biomarker for long QT syndrome. EXCLI Journal, 13, 834–842. Retrieved from https://www.excli.de/index.php/excli/article/view/745

Issue

Vol. 13 (2014)

Section

Original articles

License

Authors who publish in this journal agree to the following terms:

  • The authors keep the copyright and grant the journal the right of first publication under the terms of the Creative Commons Attribution license, CC BY 4.0. This licencse permits unrestricted use, distribution and reproduction in any medium, provided that the original work is properly cited.
  • The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.
  • Because the advice and information in this journal are believed to be true and accurate at the time of publication, neither the authors, the editors, nor the publisher accept any legal responsibility for any errors or omissions presented in the publication. The publisher makes no guarantee, express or implied, with respect to the material contained herein.
  • The authors can enter into additional contracts for the non-exclusive distribution of the journal's published version by citing the initial publication in this journal (e.g. publishing in an institutional repository or in a book).

Most read articles by the same author(s)