Pathophysiology and therapy of systemic vasculitides

Authors

  • Massimo Ralli Department of Sense Organs, Sapienza University of Rome, Viale dell’Università 33, 00168 Rome, Italy. Tel: +390649976808, E-mail: massimo.ralli@uniroma1.it http://orcid.org/0000-0001-8776-0421
  • Flaminia Campo Department of Sense Organs, Sapienza University of Rome, Italy
  • Diletta Angeletti Department of Sense Organs, Sapienza University of Rome, Italy
  • Antonio Minni Department of Sense Organs, Sapienza University of Rome, Italy
  • Marco Artico Department of Sense Organs, Sapienza University of Rome, Italy
  • Antonio Greco Department of Sense Organs, Sapienza University of Rome, Italy
  • Antonella Polimeni Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Italy
  • Marco de Vincentiis Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Italy

DOI:

https://doi.org/10.17179/excli2020-2510

Keywords:

Systemic vasculitides, Kawasaki disease, Takayasu arteritis, Polyarteritis nodosa, Giant cell arteritis, Behcet’s disease

Abstract

Systemic vasculitides represent uncommon conditions characterized by the inflammation of blood vessels that can lead to different complex disorders limited to one organ or potentially involving multiple organs and systems. Systemic vasculitides are classified according to the diameter of the vessel that they mainly affect (small, medium, large, or variable). The pathogenetic mechanisms of systemic vasculitides are still partly unknown, as well as their genetic basis. For most of the primary systemic vasculitides, a single gold standard test is not available, and diagnosis is often made after having ruled out other mimicking conditions. Current research has focused on new management protocol and therapeutic strategies aimed at improving long-term patient outcomes and avoiding progression to multiorgan failure with irreversible damage. In this narrative review, authors describe different forms of systemic vasculitides through a review of the literature, with the aim of highlighting the current knowledge and recent findings on etiopathogenesis, diagnosis and therapy.

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Published

2020-06-18

How to Cite

Ralli, M., Campo, F., Angeletti, D., Minni, A., Artico, M., Greco, A., … de Vincentiis, M. (2020). Pathophysiology and therapy of systemic vasculitides. EXCLI Journal, 19, 817–854. https://doi.org/10.17179/excli2020-2510

Issue

Vol. 19 (2020)

Section

Review articles

License

Copyright (c) 2020 Massimo Ralli, Flaminia Campo, Diletta Angeletti, Antonio Minni, Marco Artico, Antonio Greco, Antonella Polimeni, Marco de Vincentiis

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