Sensitivity of clinical isolates of Candida to essential oils from Burseraceae family

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Miloš Nikolic
Marija Smiljkovic
Tatjana Markovic
Ana Cirica
Jasmina Glamoclija
Dejan Markovic
Marina Sokovic


The aim of this study was to investigate the chemical composition and antifungal activity of four commercial essential oils from the Burseraceae family - two Boswellia carterii Flueck oils, Canarium luzonicum (Blume) A. Gray oil, and Commiphora myrrha (Nees) Engl oil, against most common Candida spp. recovered from the human oral cavity. The essential oil samples were analyzed by GC-FID and GC/MS. The analysis showed that major essential oils' components were α-pinene (23.04 % and 31.84 %), limonene (45.62 %) and curzerene (34.65 %), respectively. Minimum inhibitory (MIC) and minimum fungicidal (MFC) concentrations were determined using a microdilution standardized technique. All tested Candida spp. clinical isolates and ATCC strains showed susceptibility to tested essential oils in a dose dependent manner. The strongest antifungal activity was shown by essential oil of B. carterii, sample 2; the average MIC values ranged from 1.25 to 1.34 mg/ml, and MFC values ranged from 2.50 to 3.75 mg/ml, depending on the fungus. This study supports the possible use of essential oils from the Bursecaceae family in reduction and elimination of Candida spp. populations in patients with oral cavity fungal infections.

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Nikolic, M., Smiljkovic, M., Markovic, T., Cirica, A., Glamoclija, J., Markovic, D., & Sokovic, M. (2016). Sensitivity of clinical isolates of Candida to essential oils from Burseraceae family. EXCLI Journal, 15, 280-289.
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