Unraveling NEAT1's complex role in lung cancer biology

a comprehensive review

Authors

  • Md Sadique Hussain School of Pharmaceutical Sciences, Jaipur National University, Jagatpura 302017, Jaipur, India https://orcid.org/0000-0002-3554-1750
  • Obaid Afzal Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj, 11942, Saudi Arabia https://orcid.org/0000-0002-4188-5592
  • Gaurav Gupta School of Pharmacy, Suresh Gyan Vihar University, Jagatpura 302017, Mahal Road, Jaipur, India. E-mail: gauravpharma25@gmail.com https://orcid.org/0000-0001-7941-0229
  • Ahsas Goyal Institute of Pharmaceutical Research, GLA University, Mathura, U. P., India https://orcid.org/0000-0003-0110-9238
  • Waleed Hassan Almalki Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia https://orcid.org/0000-0003-2584-8510
  • Imran Kazmi Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
  • Sami I. Alzarea Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Al-Jouf, Saudi Arabia https://orcid.org/0000-0003-4007-4023
  • Abdulmalik Saleh Alfawaz Altamimi Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj, 11942, Saudi Arabia https://orcid.org/0009-0002-8523-9039
  • Neelam Kukreti School of Pharmacy, Graphic Era Hill University, Dehradun 248007, India https://orcid.org/0000-0002-5556-9638
  • Amlan Chakraborty Faculty of Biology, Medicine and Health, The University of Manchester, Oxford Road, Manchester M13 9PL, U.K.; Cardiovascular Disease Program, Biomedicine Discovery Institute and Department of Pharmacology, Monash University, Clayton, VIC 3800, Australia https://orcid.org/0000-0002-2917-6486
  • Sachin Kumar Singh School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia https://orcid.org/0000-0003-3823-6572
  • Kamal Dua Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Australia https://orcid.org/0000-0002-7507-1159

DOI:

https://doi.org/10.17179/excli2023-6553

Keywords:

long non-coding RNA, NEAT1, lung cancer, clinical applications, cancer

Abstract

This review delves into the pivotal role of the long non-coding RNA NEAT1 in cancer biology, particularly in lung cancer (LC). It emphasizes NEAT1's unique subcellular localization and active involvement in gene regulation and chromatin remodeling. The review highlights NEAT1's impact on LC development and progression, including cell processes such as proliferation, migration, invasion, and resistance to therapy, positioning it as a potential diagnostic marker and therapeutic target. The complex web of NEAT1's regulatory interactions with proteins and microRNAs is explored, alongside challenges in targeting it therapeutically. The review concludes optimistically, suggesting future avenues for research and personalized LC therapies, shedding light on NEAT1's crucial role in LC.

Downloads

Published

2024-01-03

How to Cite

Hussain, M. S., Afzal, O., Gupta, G., Goyal, A., Almalki, W. H., Kazmi, I., … Dua, K. (2024). Unraveling NEAT1’s complex role in lung cancer biology: a comprehensive review. EXCLI Journal, 23, 34–52. https://doi.org/10.17179/excli2023-6553

Issue

Vol. 23 (2024)

Section

Review articles

Categories

License

Copyright (c) 2024 Md Sadique Hussain, Obaid Afzal, Gaurav Gupta, Ahsas Goyal, Waleed Hassan Almalki, Imran Kazmi, Sami I. Alzarea, Abdulmalik Saleh Alfawaz Altamimi, Neelam Kukreti, Amlan Chakraborty, Sachin Kumar Singh, Kamal Dua

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish in this journal agree to the following terms:

  • The authors keep the copyright and grant the journal the right of first publication under the terms of the Creative Commons Attribution license, CC BY 4.0. This licencse permits unrestricted use, distribution and reproduction in any medium, provided that the original work is properly cited.
  • The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.
  • Because the advice and information in this journal are believed to be true and accurate at the time of publication, neither the authors, the editors, nor the publisher accept any legal responsibility for any errors or omissions presented in the publication. The publisher makes no guarantee, express or implied, with respect to the material contained herein.
  • The authors can enter into additional contracts for the non-exclusive distribution of the journal's published version by citing the initial publication in this journal (e.g. publishing in an institutional repository or in a book).

Most read articles by the same author(s)

1 2 3 > >>