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EXCLI Journal publishes original research reports, authoritative reviews and case reports of experimental and clinical sciences.

EXCLI Journal (eISSN 1611-2156) is particularly keen to keep a broad view of science and technology, and therefore welcomes papers which bridge disciplines and may not suit the narrow specialism of other journals. Although the general emphasis is on biological sciences, studies from the following fields are explicitly encouraged:

Immunology, toxicology, ergonomics, neurosciences, psychology, occupational medicine, clinical and preclinical studies, drug development, pharmacology, environmental health, chemistry including analytical chemistry, biochemistry, cell biology, genetics, forensic medicine, oncology and cancer research, proteomics, systems biology, hepatology and gastroenterology, aging research, psychiatric research, behavioral sciences.

Vol 19 (2020)

Published continuously

Published: 2020-01-02

Case report - The effects of spaced transcranial Direct Current Stimulation combined with conventional dysphagia therapy in Parkinson’s disease: A case report

Authors: Ali Akbar Dashtelei, Michael A. Nitsche, Jalal Bakhtiyari, Seyed Amirhassan Habibi, Mojtaba Sepandi, Ahmad Reza Khatoonabadi
Pages: 745-749
Published: 2020-06-04
Issue: Vol 19 (2020)

Original article - Proteomics profiling asthma induced-lysine acetylation

Authors: Xin-ming Su, Yuan Ren, Meng-lu Li, Shi-yao Bai, Na Yu, Ling-fei Kong, Jian Kang
Pages: 734-744
Published: 2020-06-04
Issue: Vol 19 (2020)

Review article - Prognostic role of immune cells in hepatocellular carcinoma

Authors: Meenakshi Sachdeva, Sunil K. Arora
Pages: 718-733
Published: 2020-06-03
Issue: Vol 19 (2020)

Review article - Molecular mechanism and health effects of 1,2-Naphtoquinone

Authors: Antonio Garcia Soares, Marcelo N. Muscara, Soraia K. P. Costa
Pages: 707-717
Published: 2020-06-03
Issue: Vol 19 (2020)

Original article - Microbiological and virulence aspects of Rhodotorula mucilaginosa

Authors: Isabele Carrilho Jarros, Flávia Franco Veiga, Jakeline Luiz Corrêa, Isabella Letícia Esteves Barros, Marina Cristina Gadelha, Morgana F. Voidaleski, Neli Pieralisi, Raissa Bocchi Pedroso, Vânia A. Vicente, Melyssa Negri, Terezinha I Estivalet Svidzinski
Pages: 687-704
Published: 2020-05-27
Issue: Vol 19 (2020)

The effects of synbiotic supplementation on serum inflammatory markers and edema volume in breast cancer survivors with lymphedema

Authors: Saeideh Vafa, Shahpar Haghighat, Leila Janani, Ali Saneei Totmaj, Mehraban Navaei, Ali Amirinejad, Hadi Emamat, Zahra Salehi, Mitra Zarrati
Pages: 1-15
Published: 2020-01-02
Issue: Vol 19 (2020)

5,6,7,4’-Tetramethoxyflavanone protects against neuronal degeneration induced by dexamethasone by attenuating amyloidogenesis in mice

Authors: Kanet Pakdeepak, Ratchanaporn Chokchaisiri, Jiraporn Tocharus, Pranglada Jearjaroen, Chainarong Tocharus, Apichart Suksamrarn
Pages: 16-32
Published: 2020-01-02
Issue: Vol 19 (2020)

Effect of Ficus glomerata leaf extract in streptozotocin-induced early diabetic complications and its characterization by LC-MS

Authors: Abusufyan Sirajuddin Shaikh, Mohammad Ibrahim, Mohib Khan, Dr.
Pages: 33-47
Published: 2020-01-03
Issue: Vol 19 (2020)

Redox status, DNA and HSA binding study of naturally occurring naphthoquinone derivatives

Authors: Milena D. Vukic, Nenad L. Vukovic, Ana Obradovic, Milos Matic, Maja Djukic, Edina Avdovic
Pages: 48-70
Published: 2020-01-03
Issue: Vol 19 (2020)

Phosphoinositide 3-kinase inhibitor AS605240 ameliorates streptozotocin-induced Alzheimer’s disease like sporadic dementia in experimental rats

Authors: Ramesh Alluri, Siva Mallikarjuna Reddy Ambati, Kasiviswanath Routhu, Spandana Rajendra Kopalli, Sushruta Koppula
Pages: 71-85
Published: 2020-01-06
Issue: Vol 19 (2020)

RNA-protein correlation of liver toxicity markers in HepaRG cells

Authors: Albert Braeuning, Almut Mentz, Felix F. Schmidt, Stefan P. Albaum, Hannes Planatscher, Jörn Kalinowski, Thomas O. Joos, Oliver Poetz, Dajana Lichtenstein
Pages: 135-153
Published: 2020-01-17
Issue: Vol 19 (2020)

CRISPR/Cas9-mediated knockout of MLL5 enhances apoptotic effect of cisplatin in HeLa cells in vitro

Authors: Mohammad Pirouzfar, Farshid Amiri, Mehdi Dianatpour, Mohammad Ali Takhshid
Pages: 170-182
Published: 2020-01-23
Issue: Vol 19 (2020)

The safety evaluation of FM101, an A3 adenosine receptor modulator, in rat, for developing as therapeutics of glaucoma and hepatitis

Authors: Chong-Woo Park, Chung-Tack Han, Yasue Sakaguchi, Jiyoun Lee, Hwa-Young Youn
Pages: 187-200
Published: 2020-02-12
Issue: Vol 19 (2020)

Association of biofilm formation with multi drug resistance in clinical isolates of Pseudomonas aeruginosa

Authors: Nazia Abdulhaq, Zeeshan Nawaz, Muhammad Asif Zahoor, Abu Baker Siddique
Pages: 201-208
Published: 2020-02-18
Issue: Vol 19 (2020)

Rational design of novel coumarins: A potential trend for antioxidants in cosmetics

Authors: Apilak Worachartcheewan, Veda Prachayasittkul, Supaluk Prachayasittkul, Visanu Tantivit, Chareef Yeeyahya, Virapong Prachayasittkikul
Pages: 209-226
Published: 2020-02-26
Issue: Vol 19 (2020)

Short term effects of coffee components consumption on gut microbiota in patients with non-alcoholic fatty liver and diabetes: A pilot randomized placebo-controlled, clinical trial

Authors: Asieh Mansour, Mohammad Reza Mohajeri-Tehrani, Sara Karimi, Milad Sanginabadi, Hossein Poustchi, Samaneh Enayati, Saeedeh Asgarbeik, Javad Nasrollahzadeh, Azita Hekmatdoost
Pages: 241-250
Published: 2020-03-02
Issue: Vol 19 (2020)

Tumor-derived urinary exosomal long non-coding RNAs as diagnostic biomarkers for bladder cancer

Authors: Maryam Abbastabar, Mohammad Sarfi, Abolfazl Golestani, Ali Karimi, Gholamreza Pourmand, Ehsan Khalili
Pages: 301-310
Published: 2020-03-04
Issue: Vol 19 (2020)

Antitrypanosomal butanolides from Aiouea trinervis

Authors: Felipe Oliveira Nunes, Júlio Menta de Almeida, Alda Maria Teixeira Ferreira, Letícia Alves da Cruz, Camila Mareti Bonin Jacob, Walmir Silva Garcez, Fernanda Rodrigues Garcez
Pages: 323-333
Published: 2020-03-06
Issue: Vol 19 (2020)

The small chain fatty acid butyrate antagonizes the TCR-stimulation-induced metabolic shift in murine epidermal γδ T cells

Authors: Lukas Häselbarth, D. Margriet Ouwens, Nadine Teichweyde, Katrin Hochrath, Katja Merches, Charlotte Esser
Pages: 334-350
Published: 2020-03-09
Issue: Vol 19 (2020)

Involvement of haptoglobin phenotypes and genotypes in non-muscle invasive bladder cancer: A possible prognostic marker for risk stratification

Authors: Nazi Aghaalikhani, Mojtaba Zamani, Abdolamir Allameh, Amir Mashayekhi, Pejman Shadpour, Marzieh Mahmoodi, Nadereh Rashtchizadeh
Pages: 351-359
Published: 2020-03-10
Issue: Vol 19 (2020)

Broad-spectrum antimicrobial activity of wetland-derived Streptomyces sp. ActiF450

Authors: Mabrouka Benhadj, Taha Menasria, Fatma Zohra Slim, Stephane Ranque
Pages: 360-371
Published: 2020-03-12
Issue: Vol 19 (2020)

Role of Kupffer cells in liver injury induced by CpG oligodeoxynucleotide and flucloxacillin in mice

Authors: Yuying Gao, Binbin Song, Shigeki Aoki, Kousei Ito
Pages: 387-399
Published: 2020-03-13
Issue: Vol 19 (2020)

Unrevealing sequence and structural features of novel coronavirus using in silico approaches: The main protease as molecular target

Authors: Joseph Thomas Ortega, Maria Luisa Serrano, Flor Helene Pujol, Hector Rafael Rangel
Pages: 400-409
Published: 2020-03-17
Issue: Vol 19 (2020)

Role of changes in SARS-CoV-2 spike protein in the interaction with the human ACE2 receptor: An in silico analysis

Authors: Joseph Thomas Ortega, Maria Luisa Serrano, Flor Helene Pujol, Hector Rafael Rangel
Pages: 410-417
Published: 2020-03-18
Issue: Vol 19 (2020)

Toxic responses of the liver and kidneys following occupational exposure to anesthetic gases

Authors: Masoud Neghab, Fatemeh Amiri, Esmaeel Soleimani, Saeed Yousefinejad, Jafar Hassanzadeh
Pages: 418-429
Published: 2020-03-25
Issue: Vol 19 (2020)

Analysis of Natural Killer cell functions in patients with hereditary hemochromatosis

Authors: Vivian Bönnemann, Maren Claus, Barbara Butzeck, Daniela Collette, Peter Bröde, Klaus Golka, Carsten Watzl
Pages: 430-441
Published: 2020-03-25
Issue: Vol 19 (2020)

Hygrophorus eburneus, edible mushroom, a promising natural bioactive agent

Authors: Marijana M. Kosanić, Dragana S. Šeklić, Milena M. Jovanović, Nevena Petrović, Snežana D. Marković
Pages: 442-457
Published: 2020-03-31
Issue: Vol 19 (2020)

QSAR-driven rational design of novel DNA methyltransferase 1 inhibitors

Authors: Chuleeporn Phanus-umporn, Veda Prachayasittikul, Chanin Nantasenamat, Supaluk Prachayasittikul, Virapong Prachayasittikul
Pages: 458-475
Published: 2020-04-02
Issue: Vol 19 (2020)

Association between HIC1 promoter methylation and solid tumor: A meta-analysis

Authors: Zhao Tie, Justice Afrifa, Dong Wang, Jingcui Yu
Pages: 476-489
Published: 2020-04-07
Issue: Vol 19 (2020)

Silver nanoparticles restrict microbial growth by promoting oxidative stress and DNA damage

Authors: Oluyomi Stephen Adeyemi, Emmanuella Oluwatosin Shittu, Oghenerobor Benjamin Akpor, Damilare E. Rotimi, Gaber El-saber Batiha
Pages: 492-500
Published: 2020-04-15
Issue: Vol 19 (2020)

Urinary PCA3 detection in prostate cancer by magnetic nanoparticles coupled with colorimetric enzyme-linked oligonucleotide assay

Authors: Vichanan Yamkamon, Khin Phyu Pyar Htoo, Sakda Yainoy, Thummaruk Suksrichavalit, Tienrat Tangchaikeeree, Warawan Eiamphungporn
Pages: 501-513
Published: 2020-04-15
Issue: Vol 19 (2020)

Perifosine and vitamin D combination induces apoptotic and non-apoptotic cell death in endometrial cancer cells

Authors: Meryem Ilkay Karagul, Savas Aktas, Sakir Necat Yilmaz, Derya Yetkin, Havva Didem Celikcan, Ozge Selin Cevik
Pages: 532-546
Published: 2020-05-04
Issue: Vol 19 (2020)

The neural basis of hazard perception differences between novice and experienced drivers - An fMRI study

Authors: Seifollah Gharib, Arash Zare-Sadeghi, Seyed Abolfazl Zakerian, Mohsen Reza Haidari
Pages: 547-566
Published: 2020-05-04
Issue: Vol 19 (2020)

Fibroblast Growth Factor–21 ameliorates hepatic encephalopathy by activating the STAT3-SOCS3 pathway to inhibit activated hepatic stellate cells

Authors: Yeboah Kwaku Opoku, Zhihang Liu, Justice Afrifa, Asare Kwame Kumi, Han Liu, George Ghartey-Kwansah, Harriet Koranteng, Xinghao Jiang, Guiping Ren, Deshan Li
Pages: 567-581
Published: 2020-05-04
Issue: Vol 19 (2020)

Bioinformatics and experimental studies of anti-leukemic activity from 6-gingerol demonstrate its role in p53 mediated apoptosis pathway

Authors: Chawalit Chatupheeraphat, Chanin Nantasenamat, Kamolchanok Deesrisak, Sittiruk Roytrakul, Usanarat Anurathapan, Dalina Tanyong
Pages: 582-595
Published: 2020-05-06
Issue: Vol 19 (2020)

Synergistic effects of quercetin and regular exercise on the recovery of spatial memory and reduction of parameters of oxidative stress in animal model of Alzheimer's disease

Authors: Amin Molaei, Homeira Hatami, Gholamreza Dehghan, Reihaneh Sadeghian, Nazli Khajehnasiri
Pages: 596-612
Published: 2020-05-08
Issue: Vol 19 (2020)

Inhibition of prostate cancer cell line (PC-3) by anhydrodihydroartemisinin (ADHA) through caspase-dependent pathway

Authors: Faiz Ahmad, Amit Sarder, Rajesh Gour, Shibendra Kumar Lal Karna, Priya Arora, P. Ravindranathan Kartha, Yuba Raj Pokharel
Pages: 613-619
Published: 2020-05-11
Issue: Vol 19 (2020)

Aloin promotes cell apoptosis by targeting HMGB1-TLR4-ERK axis in human melanoma cells

Authors: Pan Li, Kai Ren, Yin yin Liang, Ji kai Liu, Zhuo wen Liang, Yong feng Zhang
Pages: 641-651
Published: 2020-05-14
Issue: Vol 19 (2020)

Effects of vitamin D3 supplementation on clinical symptoms, quality of life, serum serotonin (5-hydroxytryptamine), 5-hydroxy-indole acetic acid, and ratio of 5-HIAA/5-HT in patients with diarrhea-predominant irritable bowel syndrome

A randomized clinical trial

Authors: Masoumeh Khalighi Sikaroudi, Marjan Mokhtare, Farzad Shidfar, Leila Janani, AmirHossein Faghihi Kashani, Mohsen Masoodi, Shahram Agah, Afsaneh Dehnad, Shahrzad Shidfar
Pages: 652-667
Published: 2020-05-19
Issue: Vol 19 (2020)

The methanolic extract of Cinnamomum zeylanicum bark improves formaldehyde-induced neurotoxicity through reduction of phospho-tau (Thr231), inflammation, and apoptosis

Authors: Sara Sayad-Fathi, Arash Zaminy, Parvin Babaei, Fatemeh Yousefbeyk, Nasibeh Azizi, Ebrahim Nasiri
Pages: 671-686
Published: 2020-05-25
Issue: Vol 19 (2020)

Ovariectomized rat model of osteoporosis: a practical guide

Authors: Nasibeh Yousefzadeh, Khosrow Kashfi, Sajad Jeddi, Asghar Ghasemi
Pages: 89-107
Published: 2020-01-10
Issue: Vol 19 (2020)

The survival rate of hepatocellular carcinoma in Asian countries: a systematic review and meta-analysis

Authors: Soheil Hassanipour, Mouhebat Vali, Saber Gaffari-fam, Hossein-Ali Nikbakht, Elham Abdzadeh, Farahnaz Joukar, Akram Pourshams, Afshin Shafaghi, Mahdi Malakoutikhah, Morteza Arab-Zozani, Hamid Salehiniya, Fariborz Mansour-Ghanaei
Pages: 108-130
Published: 2020-01-13
Issue: Vol 19 (2020)

Serotonergic system modulation holds promise for L‐DOPA‐induced dyskinesias in hemiparkinsonian rats: A systematic review

Authors: Fereshteh Farajdokht, Saeed Sadigh-Eteghad, Alireza Majdi, Fariba Pashazadeh, Seyyed Mehdi Vatandoust, Mojtaba Ziaee, Fatemeh Safari, Pouran Karimi, Javad Mahmoudi
Pages: 268-295
Published: 2020-03-02
Issue: Vol 19 (2020)

Artificial sweeteners are related to non-alcoholic fatty liver disease: Microbiota dysbiosis as a novel potential mechanism

Authors: Hadi Emamat, Hamid Ghalandari, Hadith Tangestani, Afsoun Abdollahi, Azita Hekmatdoost
Pages: 620-626
Published: 2020-05-12
Issue: Vol 19 (2020)

A recent overview on sulforaphane as a dietary epigenetic modulator

Authors: Tae Kyung Hyun
Pages: 131-134
Published: 2020-01-15
Issue: Vol 19 (2020)

Highlight Report: Hepatobiliary differentiation from human induced pluripotent stem cells

Authors: Patrick Nell
Pages: 167-169
Published: 2020-01-23
Issue: Vol 19 (2020)

Concomitant inflammation/metabolism transcriptional regulatory networks in liver disease

Authors: Tahany Abbas, Walaa Murad, Reham Hassan
Pages: 183-184
Published: 2020-01-27
Issue: Vol 19 (2020)

The in vivo genotoxicity of isotretinoin assessed by comet assay

Authors: Maede Bordbar, Zahra Zendeh-Boodi, Mostafa Saadat
Pages: 185-186
Published: 2020-02-10
Issue: Vol 19 (2020)

PPARG as therapeutic target for antifibrotic therapy

Authors: Ahmed Ghallab, Abdellatief Seddek
Pages: 227-229
Published: 2020-02-28
Issue: Vol 19 (2020)

In-utero exposure to opioid increases the risk of congenital heart defects

Authors: Kamleshun Ramphul, Stephanie G. Mejias, Jyotsnav Joynauth
Pages: 239-240
Published: 2020-03-02
Issue: Vol 19 (2020)

Linac-based radiotherapy for epicondylitis humeri

Authors: Mahmoud Navaser, Hamed Ghaffari, Mehrnaz Mashoufi, Soheila Refahi
Pages: 296-300
Published: 2020-03-04
Issue: Vol 19 (2020)

siRNA could be a potential therapy for COVID-19

Authors: Sanhita Ghosh, Sayeed Mohammad Firdous, Anirban Nath
Pages: 528-531
Published: 2020-04-22
Issue: Vol 19 (2020)

Recent studies on kaempferol and its biological and pharmacological activities

Authors: Jae Kwang Kim, Sang Un Park
Pages: 627-634
Published: 2020-05-13
Issue: Vol 19 (2020)

Current biological and pharmacological updates on wogonin

Authors: Sarita Rawat, Gaurav Gupta, Sachchidanand Pathak, Santosh Kumar Singh, Himmat Singh, Anurag Mishra, Ritu Gilhotra, Alaa A. A. Aljabali, Harish Dureja, Murtaza M. Tambuwala, Dinesh K. Chellappan, Kamal Dua
Pages: 635-640
Published: 2020-05-13
Issue: Vol 19 (2020)

Genotoxicity effect of methyl-tertiary butyl ether on rat lymphocytes using comet assay

Authors: Shima Alishahi, Zahra Zendeh-Boodi, Mostafa Saadat
Pages: 668-670
Published: 2020-05-25
Issue: Vol 19 (2020)

Nut consumption and risk of diabetes mellitus in overweight/obese individuals

Authors: Omid Eslami, Farzad Shidfar
Pages: 705-706
Published: 2020-05-29
Issue: Vol 19 (2020)
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