EXCLI Journal Logo

EXCLI Journal publishes original research reports, authoritative reviews and case reports of experimental and clinical sciences.

EXCLI Journal (eISSN 1611-2156) is particularly keen to keep a broad view of science and technology, and therefore welcomes papers which bridge disciplines and may not suit the narrow specialism of other journals. Although the general emphasis is on biological sciences, studies from the following fields are explicitly encouraged:

Immunology, toxicology, ergonomics, neurosciences, psychology, occupational medicine, clinical and preclinical studies, drug development, pharmacology, environmental health, chemistry including analytical chemistry, biochemistry, cell biology, genetics, forensic medicine, oncology and cancer research, proteomics, systems biology, hepatology and gastroenterology, aging research, psychiatric research, behavioral sciences.

Vol 19 (2020)

Published continuously

Published: 2020-01-02

Original article - Association between HIC1 promoter methylation and solid tumor: A meta-analysis

Authors: Zhao Tie, Justice Afrifa, Dong Wang, Jingcui Yu
Pages: 476-489
Published: 2020-04-07
Issue: Vol 19 (2020)

Original article - QSAR-driven rational design of novel DNA methyltransferase 1 inhibitors

Authors: Chuleeporn Phanus-umporn, Veda Prachayasittikul, Chanin Nantasenamat, Supaluk Prachayasittikul, Virapong Prachayasittikul
Pages: 458-475
Published: 2020-04-02
Issue: Vol 19 (2020)

Original article - Hygrophorus eburneus, edible mushroom, a promising natural bioactive agent

Authors: Marijana M. Kosanić, Dragana S. Šeklić, Milena M. Jovanović, Nevena Petrović, Snežana D. Marković
Pages: 442-457
Published: 2020-03-31
Issue: Vol 19 (2020)

Original article - Analysis of Natural Killer cell functions in patients with hereditary hemochromatosis

Authors: Vivian Bönnemann, Maren Claus, Barbara Butzeck, Daniela Collette, Peter Bröde, Klaus Golka, Carsten Watzl
Pages: 430-441
Published: 2020-03-25
Issue: Vol 19 (2020)

Original article - Toxic responses of the liver and kidneys following occupational exposure to anesthetic gases

Authors: Masoud Neghab, Fatemeh Amiri, Esmaeel Soleimani, Saeed Yousefinejad, Jafar Hassanzadeh
Pages: 418-429
Published: 2020-03-25
Issue: Vol 19 (2020)

Original article - Role of changes in SARS-CoV-2 spike protein in the interaction with the human ACE2 receptor: An in silico analysis

Authors: Joseph Thomas Ortega, Maria Luisa Serrano, Flor Helene Pujol, Hector Rafael Rangel
Pages: 410-417
Published: 2020-03-18
Issue: Vol 19 (2020)

The effects of synbiotic supplementation on serum inflammatory markers and edema volume in breast cancer survivors with lymphedema

Authors: Saeideh Vafa, Shahpar Haghighat, Leila Janani, Ali Saneei Totmaj, Mehraban Navaei, Ali Amirinejad, Hadi Emamat, Zahra Salehi, Mitra Zarrati
Pages: 1-15
Published: 2020-01-02
Issue: Vol 19 (2020)

5,6,7,4’-Tetramethoxyflavanone protects against neuronal degeneration induced by dexamethasone by attenuating amyloidogenesis in mice

Authors: Kanet Pakdeepak, Ratchanaporn Chokchaisiri, Jiraporn Tocharus, Pranglada Jearjaroen, Chainarong Tocharus, Apichart Suksamrarn
Pages: 16-32
Published: 2020-01-02
Issue: Vol 19 (2020)

Effect of Ficus glomerata leaf extract in streptozotocin-induced early diabetic complications and its characterization by LC-MS

Authors: Abusufyan Sirajuddin Shaikh, Mohammad Ibrahim, Mohib Khan, Dr.
Pages: 33-47
Published: 2020-01-03
Issue: Vol 19 (2020)

Redox status, DNA and HSA binding study of naturally occurring naphthoquinone derivatives

Authors: Milena D. Vukic, Nenad L. Vukovic, Ana Obradovic, Milos Matic, Maja Djukic, Edina Avdovic
Pages: 48-70
Published: 2020-01-03
Issue: Vol 19 (2020)

Phosphoinositide 3-kinase inhibitor AS605240 ameliorates streptozotocin-induced Alzheimer’s disease like sporadic dementia in experimental rats

Authors: Ramesh Alluri, Siva Mallikarjuna Reddy Ambati, Kasiviswanath Routhu, Spandana Rajendra Kopalli, Sushruta Koppula
Pages: 71-85
Published: 2020-01-06
Issue: Vol 19 (2020)

RNA-protein correlation of liver toxicity markers in HepaRG cells

Authors: Albert Braeuning, Almut Mentz, Felix F. Schmidt, Stefan P. Albaum, Hannes Planatscher, Jörn Kalinowski, Thomas O. Joos, Oliver Poetz, Dajana Lichtenstein
Pages: 135-153
Published: 2020-01-17
Issue: Vol 19 (2020)

CRISPR/Cas9-mediated knockout of MLL5 enhances apoptotic effect of cisplatin in HeLa cells in vitro

Authors: Mohammad Pirouzfar, Farshid Amiri, Mehdi Dianatpour, Mohammad Ali Takhshid
Pages: 170-182
Published: 2020-01-23
Issue: Vol 19 (2020)

The safety evaluation of FM101, an A3 adenosine receptor modulator, in rat, for developing as therapeutics of glaucoma and hepatitis

Authors: Chong-Woo Park, Chung-Tack Han, Yasue Sakaguchi, Jiyoun Lee, Hwa-Young Youn
Pages: 187-200
Published: 2020-02-12
Issue: Vol 19 (2020)

Association of biofilm formation with multi drug resistance in clinical isolates of Pseudomonas aeruginosa

Authors: Nazia Abdulhaq, Zeeshan Nawaz, Muhammad Asif Zahoor, Abu Baker Siddique
Pages: 201-208
Published: 2020-02-18
Issue: Vol 19 (2020)

Rational design of novel coumarins: A potential trend for antioxidants in cosmetics

Authors: Apilak Worachartcheewan, Veda Prachayasittkul, Supaluk Prachayasittkul, Visanu Tantivit, Chareef Yeeyahya, Virapong Prachayasittkikul
Pages: 209-226
Published: 2020-02-26
Issue: Vol 19 (2020)

Short term effects of coffee components consumption on gut microbiota in patients with non-alcoholic fatty liver and diabetes: A pilot randomized placebo-controlled, clinical trial

Authors: Asieh Mansour, Mohammad Reza Mohajeri-Tehrani, Sara Karimi, Milad Sanginabadi, Hossein Poustchi, Samaneh Enayati, Saeedeh Asgarbeik, Javad Nasrollahzadeh, Azita Hekmatdoost
Pages: 241-250
Published: 2020-03-02
Issue: Vol 19 (2020)

Effect of grape polyphenols on selected inflammatory mediators: A systematic review and meta-analysis randomized clinical trials

Authors: Fahimeh Haghighatdoost, Ali Gholami, Mitra Hariri
Pages: 251-267
Published: 2020-03-02
Issue: Vol 19 (2020)

Tumor-derived urinary exosomal long non-coding RNAs as diagnostic biomarkers for bladder cancer

Authors: Maryam Abbastabar, Mohammad Sarfi, Abolfazl Golestani, Ali Karimi, Gholamreza Pourmand, Ehsan Khalili
Pages: 301-310
Published: 2020-03-04
Issue: Vol 19 (2020)

Antitrypanosomal butanolides from Aiouea trinervis

Authors: Felipe Oliveira Nunes, Júlio Menta de Almeida, Alda Maria Teixeira Ferreira, Letícia Alves da Cruz, Camila Mareti Bonin Jacob, Walmir Silva Garcez, Fernanda Rodrigues Garcez
Pages: 323-333
Published: 2020-03-06
Issue: Vol 19 (2020)

The small chain fatty acid butyrate antagonizes the TCR-stimulation-induced metabolic shift in murine epidermal γδ T cells

Authors: Lukas Häselbarth, D. Margriet Ouwens, Nadine Teichweyde, Katrin Hochrath, Katja Merches, Charlotte Esser
Pages: 334-350
Published: 2020-03-09
Issue: Vol 19 (2020)

Involvement of haptoglobin phenotypes and genotypes in non-muscle invasive bladder cancer: A possible prognostic marker for risk stratification

Authors: Nazi Aghaalikhani, Mojtaba Zamani, Abdolamir Allameh, Amir Mashayekhi, Pejman Shadpour, Marzieh Mahmoodi, Nadereh Rashtchizadeh
Pages: 351-359
Published: 2020-03-10
Issue: Vol 19 (2020)

Broad-spectrum antimicrobial activity of wetland-derived Streptomyces sp. ActiF450

Authors: Mabrouka Benhadj, Taha Menasria, Fatma Zohra Slim, Stephane Ranque
Pages: 360-371
Published: 2020-03-12
Issue: Vol 19 (2020)

The effects of occupational exposure to manganese fume on neurobehavioral and neurocognitive functions: An analytical cross-sectional study among welders

Authors: Younes Mehrifar, Mahshid Bahrami, Esmail Sidabadi, Hamideh Pirami
Pages: 372-386
Published: 2020-03-13
Issue: Vol 19 (2020)

Role of Kupffer cells in liver injury induced by CpG oligodeoxynucleotide and flucloxacillin in mice

Authors: Yuying Gao, Binbin Song, Shigeki Aoki, Kousei Ito
Pages: 387-399
Published: 2020-03-13
Issue: Vol 19 (2020)

Unrevealing sequence and structural features of novel coronavirus using in silico approaches: The main protease as molecular target

Authors: Joseph Thomas Ortega, Maria Luisa Serrano, Flor Helene Pujol, Hector Rafael Rangel
Pages: 400-409
Published: 2020-03-17
Issue: Vol 19 (2020)

Ovariectomized rat model of osteoporosis: a practical guide

Authors: Nasibeh Yousefzadeh, Khosrow Kashfi, Sajad Jeddi, Asghar Ghasemi
Pages: 89-107
Published: 2020-01-10
Issue: Vol 19 (2020)

The survival rate of hepatocellular carcinoma in Asian countries: a systematic review and meta-analysis

Authors: Soheil Hassanipour, Mouhebat Vali, Saber Gaffari-fam, Hossein-Ali Nikbakht, Elham Abdzadeh, Farahnaz Joukar, Akram Pourshams, Afshin Shafaghi, Mahdi Malakoutikhah, Morteza Arab-Zozani, Hamid Salehiniya, Fariborz Mansour-Ghanaei
Pages: 108-130
Published: 2020-01-13
Issue: Vol 19 (2020)

Serotonergic system modulation holds promise for L‐DOPA‐induced dyskinesias in hemiparkinsonian rats: A systematic review

Authors: Fereshteh Farajdokht, Saeed Sadigh-Eteghad, Alireza Majdi, Fariba Pashazadeh, Seyyed Mehdi Vatandoust, Mojtaba Ziaee, Fatemeh Safari, Pouran Karimi, Javad Mahmoudi
Pages: 268-295
Published: 2020-03-02
Issue: Vol 19 (2020)

A recent overview on sulforaphane as a dietary epigenetic modulator

Authors: Tae Kyung Hyun
Pages: 131-134
Published: 2020-01-15
Issue: Vol 19 (2020)

Highlight Report: Hepatobiliary differentiation from human induced pluripotent stem cells

Authors: Patrick Nell
Pages: 167-169
Published: 2020-01-23
Issue: Vol 19 (2020)

Concomitant inflammation/metabolism transcriptional regulatory networks in liver disease

Authors: Tahany Abbas, Walaa Murad, Reham Hassan
Pages: 183-184
Published: 2020-01-27
Issue: Vol 19 (2020)

The in vivo genotoxicity of isotretinoin assessed by comet assay

Authors: Maede Bordbar, Zahra Zendeh-Boodi, Mostafa Saadat
Pages: 185-186
Published: 2020-02-10
Issue: Vol 19 (2020)

PPARG as therapeutic target for antifibrotic therapy

Authors: Ahmed Ghallab, Abdellatief Seddek
Pages: 227-229
Published: 2020-02-28
Issue: Vol 19 (2020)

In-utero exposure to opioid increases the risk of congenital heart defects

Authors: Kamleshun Ramphul, Stephanie G. Mejias, Jyotsnav Joynauth
Pages: 239-240
Published: 2020-03-02
Issue: Vol 19 (2020)

Linac-based radiotherapy for epicondylitis humeri

Authors: Mahmoud Navaser, Hamed Ghaffari, Mehrnaz Mashoufi, Soheila Refahi
Pages: 296-300
Published: 2020-03-04
Issue: Vol 19 (2020)
View All Issues