Anti-inflammatory effects of isoketocharbroic acid from brown alga, Sargassum micracanthum

Authors

  • Young Min Ham Jeju Biodiversity Research Institute (JBRI), Jeju Technopark, Jeju 699-943, Korea
  • Weon-Jong Yoon Jeju Biodiversity Research Institute (JBRI), Jeju Technopark, Jeju 699-943, Korea
  • Wook Jae Lee Nakdonggang National Institute of Biological Resources, Chungbuk 742-350, Korea
  • Sang-Cheol Kim Nakdonggang National Institute of Biological Resources, Chungbuk 742-350, Korea
  • Jong Seok Baik Cosmetic Science Center, Department of Chemistry and Cosmetics, Jeju National University, Jeju 690-756, Korea
  • Jin Hwa Kim R & D Center, Hanbul Cosmetics Co., Chungbuk 369-830, Korea
  • Geun Soo Lee R & D Center, Hanbul Cosmetics Co., Chungbuk 369-830, Korea
  • Nam Ho Lee Cosmetic Science Center, Department of Chemistry and Cosmetics, Jeju National University, Jeju 690-756, Korea
  • Chang-Gu Hyun Cosmetic Science Center, Department of Chemistry and Cosmetics, Jeju National University, Jeju 690-756, Korea

DOI:

https://doi.org/10.17179/excli2015-555

Keywords:

brown alga, inflammation, isoketochabrolic acid, Sargassum micracanthum

Abstract

During our on-going screening program designed to isolate natural compounds from marine environments, we isolated isoketochabrolic acid (IKCA) from Sargassum micracanthum, an important brown algae distributed in Jeju Island, Korea. Furthermore, we evaluated the inhibitory effects of IKCA on nitric oxide (NO) production in lipopolysaccharide (LPS)-triggered macrophages. IKCA strongly inhibited NO production, with an IC50 value of 58.31 μM. Subsequent studies demonstrated that IKCA potently and concentration-dependently reduced prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, and IL-6 cytokine production. In conclusion, to the best of our knowledge, this is the first study to show that IKCA isolated from S. micracanthum has a potent anti-inflammatory activity. Therefore, IKCA might be useful as an anti-inflammatory health supplement or functional cosmetics.

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Published

2015-10-15

How to Cite

Ham, Y. M., Yoon, W.-J., Lee, W. J., Kim, S.-C., Baik, J. S., Kim, J. H., … Hyun, C.-G. (2015). Anti-inflammatory effects of isoketocharbroic acid from brown alga, Sargassum micracanthum. EXCLI Journal, 14, 1116–1121. https://doi.org/10.17179/excli2015-555

Issue

Vol. 14 (2015)

Section

Original articles

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